SIRT1 silencing ameliorates malignancy of non-small cell lung cancer via activating FOXO1 DOI Creative Commons
Jiawei Chen,

Kebin Chen,

Shuai Zhang

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 28, 2024

Non-small cell lung cancer (NSCLC), being the most prevalent and lethal malignancy affecting lungs, poses a significant threat to human health. This research aims at illustrating precise role related mechanisms of silent information regulator type-1 (SIRT1) in NSCLC progression. The expression pattern SIRT1 lines was examined using quantitative real-time polymerase chain reaction western blotting. Functional assays validated biological capabilities on malignant phenotypes, its impact tumorigenicity further evaluated vivo. In addition, FOXO1 inhibitor AS1842856 applied verify FOXO pathway vitro. prominently elevated lines. depletion retarded proliferation, migration invasion, while enhancing apoptosis cells. Furthermore, silencing restricted tumorigenesis Additionally, treatment ameliorated inhibitory effect deficiency phenotypes deletion exerted an anti-oncogenic via activation FOXO1.

Language: Английский

SIRT1 silencing ameliorates malignancy of non-small cell lung cancer via activating FOXO1 DOI Creative Commons
Jiawei Chen,

Kebin Chen,

Shuai Zhang

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 28, 2024

Non-small cell lung cancer (NSCLC), being the most prevalent and lethal malignancy affecting lungs, poses a significant threat to human health. This research aims at illustrating precise role related mechanisms of silent information regulator type-1 (SIRT1) in NSCLC progression. The expression pattern SIRT1 lines was examined using quantitative real-time polymerase chain reaction western blotting. Functional assays validated biological capabilities on malignant phenotypes, its impact tumorigenicity further evaluated vivo. In addition, FOXO1 inhibitor AS1842856 applied verify FOXO pathway vitro. prominently elevated lines. depletion retarded proliferation, migration invasion, while enhancing apoptosis cells. Furthermore, silencing restricted tumorigenesis Additionally, treatment ameliorated inhibitory effect deficiency phenotypes deletion exerted an anti-oncogenic via activation FOXO1.

Language: Английский

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