Cardiomyocyte-specific Piezo1 deficiency mitigates ischemia-reperfusion injury by preserving mitochondrial homeostasis DOI Creative Commons
Honglin Xu, Xin Chen,

Shangfei Luo

et al.

Redox Biology, Journal Year: 2024, Volume and Issue: 79, P. 103471 - 103471

Published: Dec. 27, 2024

Ca2+ overload and mitochondrial dysfunction play crucial roles in myocardial ischemia-reperfusion (I/R) injury. Piezo1, a mechanosensitive cation channel, is essential for intracellular homeostasis. The objective of this research was to explore the effects Piezo1 on function during I/R We showed that expression elevated infracted area cardiomyocyte-specific deficiency (Piezo1△Myh6) mice attenuated by decreasing infarct size cardiac dysfunction. Piezo1△Myh6 regulated fusion fission improve decrease inflammation oxidative stress vivo vitro. Mechanistically, knockout alleviated calcium normalize calpain-associated Our findings indicated depletion cardiomyocytes partially restored homeostasis ischemia/reperfusion This study suggests an innovative therapeutic strategy alleviate

Language: Английский

Mitochondrial Structure and Function in Human Heart Failure DOI
Antentor Hinton, Steven M. Claypool, Kit Neikirk

et al.

Circulation Research, Journal Year: 2024, Volume and Issue: 135(2), P. 372 - 396

Published: July 4, 2024

Despite clinical and scientific advancements, heart failure is the major cause of morbidity mortality worldwide. Both mitochondrial dysfunction inflammation contribute to development progression failure. Although crucial reparative healing following acute cardiomyocyte injury, chronic damages heart, impairs function, decreases cardiac output. Mitochondria, which comprise one third volume, may prove a potential therapeutic target for Known primarily energy production, mitochondria are also involved in other processes including calcium homeostasis regulation cellular apoptosis. Mitochondrial function closely related morphology, alters through dynamics, thus ensuring that needs cell met. However, failure, changes substrate use lead impaired myocyte function. This review discusses cristae role contact site organizing system complex ultrastructure changes. Additionally, this covers mitochondria-endoplasmic reticulum sites, communication via nanotunnels, altered metabolite production during We highlight these often-neglected factors promising targets

Language: Английский

Citations

30
Myocardial Ischemia–Reperfusion Injury: Unraveling Pathophysiology, Clinical Manifestations, and Emerging Prevention Strategies DOI Creative Commons
Μarios Sagris, Anastasiοs Apostolos, Panagiotis Theofilis

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(4), P. 802 - 802

Published: April 4, 2024

Myocardial ischemia–reperfusion injury (MIRI) remains a challenge in the context of reperfusion procedures for myocardial infarction (MI). While early revascularization stands as gold standard mitigating injury, recent insights have illuminated paradoxical role reperfusion, giving rise to phenomenon known injury. This comprehensive review delves into intricate pathophysiological pathways involved MIRI, placing particular focus on pivotal endothelium. Beyond elucidating molecular intricacies, we explore diverse clinical manifestations associated with underscoring its potential contribute substantially final infarct size, up 50%. We further navigate through current preventive approaches and highlight promising emerging strategies designed counteract devastating effects phenomenon. By synthesizing knowledge offering perspective evolving interventions, this serves valuable resource clinicians researchers engaged dynamic field MIRI.

Language: Английский

Citations

17
Potential therapeutic value of dietary polysaccharides in cardiovascular disease: Extraction, mechanisms, applications, and challenges DOI
Qiqi Jin, Bin Lin, Lingeng Lu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 296, P. 139573 - 139573

Published: Jan. 8, 2025

Language: Английский

Citations

0
Phloretin and Enalapril co-administration ameliorates hyperglycemia mediated exacerbation of myocardial injury in rats DOI

Prasanti Sharma,

J.K. Bhattacharyya,

Neelima Sharma

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177394 - 177394

Published: Feb. 1, 2025

Language: Английский

Citations

0
Curcumin alleviates atrazine-induced nephrotoxicity by enhancing mitophagy through PINK1/Parkin signaling pathway in mice DOI Creative Commons

Zhenyu Zou,

Xinyi Cheng, Jinyan Chen

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 295, P. 118118 - 118118

Published: April 1, 2025

Atrazine (ATR), a widely used herbicide, poses significant environmental and health risks due to its high solubility adsorption in soil. ATR exposure can lead nephrotoxicity humans animals. Curcumin (Cur), an active compound Curcuma species, is renowned for antioxidant anti-inflammatory properties, with potential mitigate chronic disease risks. We hypothesized that the addition of Cur could alleviate renal impairment associated carried out experiments using mice as subjects. This study investigates whether attenuate ATR-induced by modulating mitophagy apoptotic pathways. Our findings illustrate consumption attenuates induced ATR, evidenced lowered serum concentrations uric acid (UA), blood urea nitrogen (BUN), creatinine (CRE), established biomarkers injury. Moreover, enhances defense mechanisms ATR-exposed mice, indicated elevated levels total capacity (T-AOC), catalase (CAT), glutathione peroxidase (GSH-Px), alongside reduced malondialdehyde (MDA). Histopathological electron microscopy analyses further corroborate these findings, showing organelle damage, particularly mitochondrial ridge breakage vacuolization, increased autophagic lysosomes. PINK1/Parkin-mediated autophagy, PINK1, Parkin, LC3BII, P62 compared ATR-treated mice. mitigates pathway, down-regulation apoptosis-related genes (Cytochrome C (Cyto-C), Caspase3, Caspase9) pro-apoptotic marker (Bax), along up-regulation anti-apoptotic (Bcl-2) at both transcriptional translational In summary, demonstrates nephroprotective properties against injury through enhancement autophagy display actions, underscoring curative potency treatment caused ATR.

Language: Английский

Citations

0
The Importance of Mitochondrial Processes in the Maturation and Acquisition of Competences of Oocytes and Embryo Culture DOI Open Access
Elżbieta Gałęska, Alicja Kowalczyk, Marcjanna Wrzecińska

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4098 - 4098

Published: April 25, 2025

Mitochondria, as multifunctional and partially independent structures, play a crucial role in determining essential life processes. Recently, their significance reproductive biology has gained increasing attention. This review aims to comprehensively analyse the of mitochondrial processes oocyte maturation embryo culture. A comprehensive literature was conducted highlight importance activity early stages formation. Proper function provides energy, maintains genomic stability, ensures optimal conditions for fertilisation progression. Understanding these is optimise culture identify new biomarkers that improve success assisted technologies (ARTs). Enhancing female cells key improving quality, which can lead better vitro transfer. Furthermore, advances diagnostic techniques, such genome sequencing, offer more precise understanding relationship between health quality. However, fully functions only part challenge. Expanding knowledge interactions mitochondria other cellular structures future advancements medicine. complex relationships will provide deeper insight into outcomes development.

Language: Английский

Citations

0
Shaping cardiac destiny: the role of post-translational modifications on endoplasmic reticulum – mitochondria crosstalk in cardiac remodeling DOI Creative Commons
Xiaohan Zhang,

Shuqing Shi,

Yihang Du

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 11, 2024

Cardiac remodeling is a shared pathological change in most cardiovascular diseases. Encompassing both adaptive physiological responses and decompensated changes. Anatomically, atrial primarily caused by fibrillation, whereas ventricular typically induced myocardial infarction, hypertension, or cardiomyopathy. Mitochondria, the powerhouse of cardiomyocytes, collaborate with other organelles such as endoplasmic reticulum to control variety pathophysiological processes calcium signaling, lipid transfer, mitochondrial dynamics, biogenesis, mitophagy. This mechanism proven be essential for cardiac remodeling. Post-translational modifications can regulate intracellular signaling pathways, gene expression, cellular stress cells modulating protein function, stability, interactions, consequently shaping response injury stress. These modifications, particular phosphorylation, acetylation, ubiquitination, are regulation complex molecular pathways that underlie review provides comprehensive overview crosstalk between mitochondria during remodeling, focusing on regulatory effects various post-translational these interactions.

Language: Английский

Citations

2
MCU inhibition protects against intestinal ischemia‒reperfusion by inhibiting Drp1-dependent mitochondrial fission DOI Creative Commons

Tulanisa Kadier,

Yi-guo Zhang,

Yixin Jing

et al.

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 221, P. 111 - 124

Published: May 17, 2024

Intestinal ischemia‒reperfusion (IIR) injury is a common complication of surgery, but clear molecular insights and valuable therapeutic targets are lacking. Mitochondrial calcium overload an early sign various diseases considered vital factor in injury. The mitochondrial uniporter (MCU), which located on the inner membrane, primary mediator ion entry into mitochondria. However, specific mechanism MCU IIR remains to be clarified. In this study, we generated model using C57BL/6 mice Caco-2 cells found increases levels expression following inhibition markedly attenuated Moreover, knockdown alleviates dysfunction by reducing oxidative stress apoptosis. Mechanistically, substantially reduced translocation Drp1 thus its binding Fis1 receptors, resulting decreased fission. Taken together, our findings demonstrated that novel upstream regulator represents predictive target for IIR.

Language: Английский

Citations

2
Mitochondria in skeletal system-related diseases DOI Open Access

Liang Pei,

Zizhen Yao, Liang Dong

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 181, P. 117505 - 117505

Published: Nov. 4, 2024

Language: Английский

Citations

2
Oxidative Stress and Inflammation in Myocardial Ischemia–Reperfusion Injury: Protective Effects of Plant‐Derived Natural Active Compounds DOI
Jia Chen, Boyu Wang, Tianwei Meng

et al.

Journal of Applied Toxicology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 31, 2024

ABSTRACT Acute myocardial infarction (AMI) remains a leading cause of death among patients with cardiovascular diseases. Percutaneous coronary intervention (PCI) has been the preferred clinical treatment for AMI due to its safety and efficiency. However, research indicates that rapid restoration oxygen supply following PCI can lead secondary injury, termed ischemia–reperfusion injury (MIRI), posing grave threat patient survival. Despite ongoing efforts, mechanisms underlying MIRI are not yet fully elucidated. Among them, oxidative stress inflammation stand out as critical pathophysiological mechanisms, playing significant roles in MIRI. Natural compounds have shown strong therapeutic potential their high efficacy, availability, low side effects. Many current studies indicate natural mitigate by reducing inflammatory responses. Therefore, this paper reviews during role intervening these processes, aiming provide basis reference future development drugs treating

Language: Английский

Citations

0