The multi-level effect of chlorpyrifos during clownfish metamorphosis DOI Creative Commons
Mathieu Reynaud, Stefano Vianello,

Shu‐Hua Lee

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 4, 2024

Abstract Chemical pollution in coastal waters, particularly from agricultural runoff organophosphates, poses a significant threat to marine ecosystems, including coral reefs. Pollutants such as chlorpyrifos (CPF) are widely used agriculture and have adverse effects on life humans. In this paper, we investigate the impact of CPF metamorphosis reef fish model, clownfish Amphiprion ocellaris , focusing disruption thyroid hormone (TH) signalling pathways. Our findings reveal that by reducing TH levels, exposure impairs formation characteristic white bands larvae, indicative progression. Interestingly, treatment can rescue these effects, establishing direct causal link between effect disruption. The body shape changes occurring during also impacted exposure, less advanced CPF-treated larvae than control conditions. Moreover, transcriptomic analysis elucidates CPF’s all components pathway. Additionally, induces systemic cholesterol vitamin D metabolism, DNA repair, immunity, highlighting its broader TH-independent impacts. often overlooked Developing enhancing models, offers more comprehensive understanding how chemical affects ecosystems. This approach provides new insights into complex mechanisms underlying toxicity metamorphosis, shedding light environmental pollutants organisms. Highlights Chlorpyrifos is an insecticide for past five decades has humans progression During lose their elongated transform miniature ovoid-shaped adults, impacts

Language: Английский

The multi-level effect of chlorpyrifos during clownfish metamorphosis DOI Creative Commons
Mathieu Reynaud, Stefano Vianello,

Shu‐Hua Lee

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 4, 2024

Abstract Chemical pollution in coastal waters, particularly from agricultural runoff organophosphates, poses a significant threat to marine ecosystems, including coral reefs. Pollutants such as chlorpyrifos (CPF) are widely used agriculture and have adverse effects on life humans. In this paper, we investigate the impact of CPF metamorphosis reef fish model, clownfish Amphiprion ocellaris , focusing disruption thyroid hormone (TH) signalling pathways. Our findings reveal that by reducing TH levels, exposure impairs formation characteristic white bands larvae, indicative progression. Interestingly, treatment can rescue these effects, establishing direct causal link between effect disruption. The body shape changes occurring during also impacted exposure, less advanced CPF-treated larvae than control conditions. Moreover, transcriptomic analysis elucidates CPF’s all components pathway. Additionally, induces systemic cholesterol vitamin D metabolism, DNA repair, immunity, highlighting its broader TH-independent impacts. often overlooked Developing enhancing models, offers more comprehensive understanding how chemical affects ecosystems. This approach provides new insights into complex mechanisms underlying toxicity metamorphosis, shedding light environmental pollutants organisms. Highlights Chlorpyrifos is an insecticide for past five decades has humans progression During lose their elongated transform miniature ovoid-shaped adults, impacts

Language: Английский

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