Puerarin Ameliorates Ferroptosis in Neuronal Injury Through the PI3K/AKT Signaling Pathway DOI
Rong Hu,

Zi-tan Peng,

Hui Liu

et al.

Nutrition and Cancer, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 9

Published: Nov. 3, 2024

Ferroptosis plays an important role in the pathogenesis of neuronal damage, generally mediated by iron and lipid peroxidation. In present study, we measured protective effects puerarin against corticosterone-induced injury via PI3K/AKT-mediated activation nuclear factor erythroid 2-related 2 (Nrf2). After exposing corticosterone-treated PC12 cells to indicated compounds, key regulators ferroptosis (ferritin, SLC7A11, Ptgs2), events (levels iron, ROS, MDA, GSH), PI3K/AKT/Nrf2 axis. Corticosterone induced cells, evidenced reduced levels ferritin, GSH increased MDA. These were reversed inhibiting with ferrostatin-1. Puerarin-mediated Nrf2 repressed upregulating ferritin SLC7A11 expression. Moreover, on relied PI3K/AKT pathway though upregulation Nrf2. findings indicate that essential protects

Language: Английский

Innate Immunity Never “NODs” Off: NLRs Regulate the Host Anti‐Viral Immune Response DOI Creative Commons
Mackenzie K. Woolls,

Madeline Mott,

Cassandra S. Poole

et al.

Immunological Reviews, Journal Year: 2025, Volume and Issue: 330(1)

Published: Jan. 29, 2025

ABSTRACT A robust innate immune response is essential in combating viral pathogens. However, it equally critical to quell overzealous signaling limit collateral damage and enable inflammation resolution. Pattern recognition receptors are regulators of these processes. The cytosolic nucleotide‐binding domain leucine‐rich repeat (NLR; NOD‐like receptor) family pattern plays roles the sensing pathogen‐associated molecular patterns best characterized for itsr pro‐inflammatory biological functions. Specifically, include formation multi‐protein complexes, defined as inflammasomes or NODosomes that regulate production IL‐1beta, IL‐18, pyroptosis, induction NF‐ΚB signaling. While effects inherently pro‐inflammatory, also important recognize other NLR members conversely function negatively through modulating initiated by families receptors. Mechanistically, unique NLRs form multiprotein complexes act attenuate a variety pathways, such inhibition NF‐ΚB. This facilitates resolution functions restore cellular homeostasis. Despite extensive characterization individual members, mechanisms system regulation highly nuanced remain enigmatic. especially true non‐inflammasome‐forming, regulatory NLRs. Here, we discuss recent findings associated with play host viruses which may antiviral immunity.

Language: Английский

Citations

3
The metabolites of gut microbiota: their role in ferroptosis in inflammatory bowel disease DOI Creative Commons
Jingying Zhou,

Peicheng Lu,

Haolong He

et al.

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: April 7, 2025

Inflammatory bowel disease (IBD) includes chronic inflammatory conditions, such as Crohn's and ulcerative colitis, characterized by impaired function of the intestinal mucosal epithelial barrier. In recent years, ferroptosis, a novel form cell death, has been confirmed to be involved in pathological process IBD is related various changes, oxidative stress inflammation. Recent studies have further revealed complex interactions between microbiome indicating that ferroptosis an important target for regulation gut microbiota its metabolites. This article reviews significant roles microbial metabolites, short-chain fatty acids, tryptophan, bile IBD. These metabolites participate influencing microenvironment, modulating immune responses, altering levels, thereby exerting impact on development Treatments based are gradually becoming research hotspot. Finally, we discuss potential current therapeutic approaches, including antibiotics, probiotics, prebiotics, fecal transplantation, microbiota, affecting improving symptoms. With deeper understanding interaction mechanisms it expected more precise effective treatment strategies will developed future.

Language: Английский

Citations

0
Mitophagy in Cell Death Regulation: Insights into Mechanisms and Disease Implications DOI Creative Commons

Jiani Lin,

Xinyao Chen, Yuyang Du

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(10), P. 1270 - 1270

Published: Oct. 9, 2024

Mitophagy, a selective form of autophagy, plays crucial role in maintaining optimal mitochondrial populations, normal function, and intracellular homeostasis by monitoring removing damaged or excess mitochondria. Furthermore, mitophagy promotes degradation via the lysosomal pathway, not only eliminates mitochondria but also regulates programmed cell death-associated genes, thus preventing death. The interaction between various forms death has recently gained increasing attention relation to pathogenesis clinical diseases, such as cancers osteoarthritis, neurodegenerative, cardiovascular, renal diseases. However, despite abundant literature on this subject, there is lack understanding regarding In review, we discuss main pathways mitophagy, those related mechanisms (including apoptosis, ferroptosis, pyroptosis), relationship uncovered recent years. Our study offers potential directions for therapeutic intervention disease diagnosis, contributes molecular mechanism mitophagy.

Language: Английский

Citations

2
Ro 90-7501 suppresses colon cancer progression by inducing immunogenic cell death and promoting RIG-1-mediated autophagy DOI

Xuening Zhao,

Zhenshuai Zhang,

Jian Wang

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113631 - 113631

Published: Nov. 15, 2024

Language: Английский

Citations

1
The WFS1‐ZnT3‐Zn2+ Axis Regulates the Vicious Cycle of Obesity and Depression DOI Creative Commons

Mengting Gong,

Yulin Fang,

Kaijiang Yang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 11, 2024

Abstract Obesity, a growing global health concern, is closely linked to depression. However, the neural mechanism of association between obesity and depression remains poorly understood. In this study, neural‐specific WFS1 deficiency exacerbates vicious cycle in mice fed high‐fat diet (HFD), positioning as crucial factor cycle. Through human pluripotent stem cells (hESCs) differentiation, it demonstrated that regulates Zn 2+ homeostasis apoptosis progenitor (NPCs) cerebral organoids by inhibiting zinc transporter ZnT3 under situation dysregulated lipid metabolism. Notably, riluzole expression maintain protect NPCs from lipotoxicity‐induced cell death. Importantly, riluzole, therapeutic molecule targeting nervous system, vivo administration prevents HFD‐induced associated Thus, WFS1‐ZnT3‐Zn axis critical for may have potential reverse process against

Language: Английский

Citations

0
Puerarin Ameliorates Ferroptosis in Neuronal Injury Through the PI3K/AKT Signaling Pathway DOI
Rong Hu,

Zi-tan Peng,

Hui Liu

et al.

Nutrition and Cancer, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 9

Published: Nov. 3, 2024

Ferroptosis plays an important role in the pathogenesis of neuronal damage, generally mediated by iron and lipid peroxidation. In present study, we measured protective effects puerarin against corticosterone-induced injury via PI3K/AKT-mediated activation nuclear factor erythroid 2-related 2 (Nrf2). After exposing corticosterone-treated PC12 cells to indicated compounds, key regulators ferroptosis (ferritin, SLC7A11, Ptgs2), events (levels iron, ROS, MDA, GSH), PI3K/AKT/Nrf2 axis. Corticosterone induced cells, evidenced reduced levels ferritin, GSH increased MDA. These were reversed inhibiting with ferrostatin-1. Puerarin-mediated Nrf2 repressed upregulating ferritin SLC7A11 expression. Moreover, on relied PI3K/AKT pathway though upregulation Nrf2. findings indicate that essential protects

Language: Английский

Citations

0