Calcium signaling hypothesis: A non-negligible pathogenesis in Alzheimer’s disease

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Alzheimer's disease (AD) presents a significant challenge to global healthcare systems, with an exacerbation by aging population. Although the plethora of hypotheses are proposed elucidate underlying mechanisms AD, from amyloid-beta (Aβ) accumulation and Tau protein aggregation neuroinflammation, comprehensive understanding its pathogenesis remains elusive. Recent research has highlighted critical role calcium (Ca This review aims consolidate current Ca The focuses on three principal concepts. First, indispensable

Language: Английский

Oleuropein: a narrative review on its role in neurodegenerative diseases

Aging advances., Journal Year: 2025, Volume and Issue: 2(2), P. 75 - 83

Published: April 8, 2025

Olive oil, a cornerstone of the Mediterranean diet, contains trace amounts oleuropein, polyphenolic compound and its active metabolite hydroxytyrosol, which exhibit significant neuroprotective effects by reducing oxidative stress brain inflammation. These properties make them promising for managing neurodegenerative diseases such as Alzheimer’s disease. This review synthesizes current literature on chemistry, biosynthesis, activities oleuropein emphasizing their antioxidant anti-inflammatory effects. Research indicates that hydroxytyrosol is bioavailable rapidly distributed throughout body, including tissue, due to ability cross blood-brain barrier. In contrast, requires metabolic conversion bioavailability. Both compounds have been shown in preclinical animal studies mitigate stress, promote autophagy, facilitate clearance amyloid-beta aggregates. Moreover, they found alleviate mitochondrial damage dysfunction, are critical factors neurodegeneration. human studies, improved cognitive function, reduced neuroinflammation, overall health. The mechanisms underlying these include restoration redox balance modulation inflammatory pathways aging brain. Despite findings, clinical trials needed assess long-term safety efficacy settings. Understanding role neuroprotection could lead effective interventions preventing or slowing decline associated with diseases. Overall, represent compelling area study within realm antioxidants application neuroprotection.

Language: Английский

Glial polarization in neurological diseases: Molecular mechanisms and therapeutic opportunities

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 104, P. 102638 - 102638

Published: Dec. 12, 2024

Language: Английский