Analysis of cellular senescence-related genes in calcified aortic valve disease and the potential therapeutic role of β-Carotene DOI Creative Commons
Yijing Tao, Chengjie Gao, Juan Wang

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(3), P. e0318574 - e0318574

Published: March 10, 2025

Objective Calcific aortic valve disease (CAVD) is a progressive, age-related degenerative characterized by the accumulation of calcium deposits in valve. We aim to screen key genes associated with cellular senescence (CS) CAVD. Methods The GSE12644 and GSE51472 datasets from GEO database was utilized this study, differentially expressed (DEGs) were identified using “ limma ” R package. CS-related DEGs (CS-DEGs) determined through CellAge database. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analyses performed on CS-DEGs. A protein–protein interaction (PPI) network constructed STRING cytoHubba plug-in Cytoscape used identify hub genes. noncoding-RNA-mRNA regulatory established. DSigDB drugs potentially be useful for treating Results total 16 CS-DEGs identified. These primarily collagen metabolic process, catabolic process external side plasma membrane. 10 as regulators CAVD: LPAR1, PTPN6, CD28, ID1, MEIS2, FGFR3, KDR, MMP7, AR, HIF1A. Noncoding RNA-mRNA indicated that may regulated noncoding RNAs. β-Carotene, naturally occurring carotenoid antioxidant properties, potential therapeutic agents interacting MMP9, CTSB. Conclusion This study provides insights into pathways related CAVD (MMP9, CTSB) highlights role β-Carotene treatment

Language: Английский

Analysis of cellular senescence-related genes in calcified aortic valve disease and the potential therapeutic role of β-Carotene DOI Creative Commons
Yijing Tao, Chengjie Gao, Juan Wang

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(3), P. e0318574 - e0318574

Published: March 10, 2025

Objective Calcific aortic valve disease (CAVD) is a progressive, age-related degenerative characterized by the accumulation of calcium deposits in valve. We aim to screen key genes associated with cellular senescence (CS) CAVD. Methods The GSE12644 and GSE51472 datasets from GEO database was utilized this study, differentially expressed (DEGs) were identified using “ limma ” R package. CS-related DEGs (CS-DEGs) determined through CellAge database. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analyses performed on CS-DEGs. A protein–protein interaction (PPI) network constructed STRING cytoHubba plug-in Cytoscape used identify hub genes. noncoding-RNA-mRNA regulatory established. DSigDB drugs potentially be useful for treating Results total 16 CS-DEGs identified. These primarily collagen metabolic process, catabolic process external side plasma membrane. 10 as regulators CAVD: LPAR1, PTPN6, CD28, ID1, MEIS2, FGFR3, KDR, MMP7, AR, HIF1A. Noncoding RNA-mRNA indicated that may regulated noncoding RNAs. β-Carotene, naturally occurring carotenoid antioxidant properties, potential therapeutic agents interacting MMP9, CTSB. Conclusion This study provides insights into pathways related CAVD (MMP9, CTSB) highlights role β-Carotene treatment

Language: Английский

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