Ferroptosis and its impact on common diseases DOI Creative Commons

Pengjian Zou,

Qiuming He,

Huimin Xia

et al.

PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e18708 - e18708

Published: Dec. 19, 2024

Ferroptosis is a novel form of programmed cell death characterized by iron accumulation, lipid peroxidation, and decline in antioxidant capacity, all which are regulated gene expression. The onset numerous diseases closely associated with ferroptosis. Common affect large population, reduce the quality life, impose an increased burden on healthcare system. role ferroptosis common diseases, its therapeutic potential, even translation into clinical drug treatments currently significant research topics worldwide. This study preliminarily explores theoretical basis ferroptosis, mechanism treatment prospect including ischaemia-reperfusion injury, inflammatory bowel liver fibrosis, acute kidney diabetic disease, stroke, Alzheimer’s cardiovascular immune cancer. review provides foundation for further development as well prevention diseases.

Language: Английский

Synergistic anti-oxidative/anti-inflammatory treatment for acute lung injury with selenium based chlorogenic acid nanoparticles through modulating Mapk8ip1/MAPK and Itga2b/PI3k-AKT axis DOI Creative Commons

Huizhen Xing,

Xueli Bai,

Xiaoying Pei

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 23, 2025

Language: Английский

Citations

1
The Application of Selenium Nanoparticles in Immunotherapy DOI Creative Commons
Yu Yang, Ying Liu, Qingxia Yang

et al.

Nano Biomedicine and Engineering, Journal Year: 2024, Volume and Issue: 16(3), P. 345 - 356

Published: Sept. 1, 2024

Language: Английский

Citations

5
Piper betle extract inhibits ferroptosis by scavenging oxyradicals, hydroperoxides and inducing NRF2 regulated antioxidants DOI

Veena Ranganathan,

Vidyaranyapura S. Deepashree,

Jadeppa Gowda

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106325 - 106325

Published: March 1, 2025

Language: Английский

Citations

0
Selenium nanoparticles attenuate retinal pathological angiogenesis by disrupting cell cycle distribution DOI

Zheng Nie,

Yongxuan Liu, Xu Li

et al.

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 14

Published: March 21, 2025

This study aims to explore the mechanism by which selenium nanoparticles (SeNPs) inhibit retinal neovascularization (RNV) and identify a more effective treatment for pathological RNV. The characterization identification of synthesized were conducted investigate their effects on function human umbilical vein endothelial cells (HUVECs), blood vessel development in mice, impact oxygen-induced retinopathy. Tritium-labeled thymine was utilized label newly DNA both vivo vitro, allowing observation SeNPs' cell proliferation. Additionally, flow cytometry, immunofluorescence, western blotting techniques employed elucidate mechanisms SeNPs neovascularization. can significantly functions vascular cells, particularly proliferation, vitro. achieve this modulating expression cycle-related proteins through regulation PI3K-AKT-p21 axis, turn inhibits transition cycle from G1 phase S phase. may be novel interference

Language: Английский

Citations

0
Exploring the Neuroprotective Role of Selenium: Implications and Perspectives for Central Nervous System Disorders DOI Creative Commons
Guanning Huang, Ying Liu,

X. W. Zhu

et al.

Exploration, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

ABSTRACT Selenium (Se) is a crucial element in selenoproteins, key biomolecules for physiological function vivo. As selenium‐rich organ, the central nervous system can express all 25 kinds of which protect neurons by reducing oxidative stress and inflammatory response. However, decreased Se levels are prevalent variety neurological disorders, not conducive to treatment prognosis patients. Thus, biological study has emerged as focal point investigating pivotal role trace elements neuroprotection. This paper presents comprehensive review pathogenic mechanism diseases, protective Se, selenoproteins. Additionally, application neuroprotective agent disorder therapy, including ischemic stroke, Alzheimer's, Parkinson's, other summarized. The present aims offer novel insights methodologies prevention disorders with providing scientific basis development innovative Se‐based neuroprotectants promote their clinical against diseases.

Language: Английский

Citations

0
Cascade-Targeting Hydrogel Microspheres with Biomimetic Nanoparticles Enable Multifaceted Anti-Inflammatory and Antioxidant Defense for Osteoarthritis Management DOI
Shengli Ma, Yuqiao Sheng, Chaoyang Zhang

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Ferroptosis-associated pathological injury mechanisms and therapeutic strategies after intracerebral hemorrhage DOI Creative Commons
Yuhua Gong, Fu‐Chi Yang, Ying Liu

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: May 1, 2025

Intracerebral hemorrhage (ICH) is an important neurological disease caused by the rupture of blood vessels in brain parenchyma, with a high mortality and disability rate. At present, many studies have focused on injury mechanisms intervention strategies after ICH. However, there no effective clinical treatment that can significantly improve prognosis ICH patients. Ferroptosis, regulated form cell death, has been identified as significant contributor to tissues damage dysfunction following The hallmark ferroptosis iron-dependent lipid peroxidation, which closely related pathological process iron overload oxidative stress Exploring interaction between post-ICH will contribute our understanding key pathways involved ferroptosis-related facilitating discovery appropriate strategies. On this basis, we present comprehensive overview (e.g., overload, stress, inflammatory response mass effect) pathogenesis development Following ICH, degradation hematoma metabolism provide fundamental material basis for ferroptosis, primarily participates peroxidation via molecular (such GPX4). By synthesizing current evidence, article aims theoretical foundation future research therapeutic targeting

Language: Английский

Citations

0
Ginsenoside Rd alleviates early brain injury by inhibiting ferroptosis through cGAS/STING/DHODH pathway after subarachnoid hemorrhage DOI

Guang-you Jiang,

Hong-rui Yang,

Chen Li

et al.

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

3
Bibliometric analysis of autophagy in NAFLD from 2004 to 2023 DOI Creative Commons
Sumei Xu, Yating Zhang, Qi Huang

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(49), P. e40835 - e40835

Published: Dec. 6, 2024

Background: Autophagy is a cellular process in which damaged organelles or unnecessary proteins are encapsulated into double-membrane structures and transported to lysosomes for degradation. plays crucial role various liver diseases, including nonalcoholic fatty disease. This study aims elucidate the of autophagy disease through bibliometric analysis. Methods: Literature was retrieved from Web Science CoreCollection database, search time January 01, 2004 December 31, 2023. Data retrieval performed using Bibliometrix package R software. VOSviewer CiteSpace were utilized visualize research hotspots trends related effect on Results: A total 966 papers obtained, published 343 journals 1385 institutions across 57 countries. The with most publications “International Journal Molecular Sciences” “Scientific Reports.” China had highest number papers. productive authors Yen Paul M Jung Tae Woo, while Singh frequently co-cited author. Emerging associated keywords such as insulin resistance, ferroptosis, endoplasmic reticulum stress, mitochondrial function. Conclusion: Research still its early stages, growing body literature. first provide comprehensive analysis, synthesizing advancements. It identifies current development trends, global cooperation models, foundational knowledge, hotspots, emerging frontiers field.

Language: Английский

Citations

0
Ferroptosis and its impact on common diseases DOI Creative Commons

Pengjian Zou,

Qiuming He,

Huimin Xia

et al.

PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e18708 - e18708

Published: Dec. 19, 2024

Ferroptosis is a novel form of programmed cell death characterized by iron accumulation, lipid peroxidation, and decline in antioxidant capacity, all which are regulated gene expression. The onset numerous diseases closely associated with ferroptosis. Common affect large population, reduce the quality life, impose an increased burden on healthcare system. role ferroptosis common diseases, its therapeutic potential, even translation into clinical drug treatments currently significant research topics worldwide. This study preliminarily explores theoretical basis ferroptosis, mechanism treatment prospect including ischaemia-reperfusion injury, inflammatory bowel liver fibrosis, acute kidney diabetic disease, stroke, Alzheimer’s cardiovascular immune cancer. review provides foundation for further development as well prevention diseases.

Language: Английский

Citations

0