Liver‐Secreted Extracellular Vesicles Promote Cirrhosis‐Associated Skeletal Muscle Injury Through mtDNA‐cGAS/STING Axis
Xiaoli Fan,
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Yunke Peng,
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Bo Li
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et al.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 13, 2025
Abstract
Skeletal
muscle
atrophy
(sarcopenia)
is
a
serious
complication
of
liver
cirrhosis,
and
chronic
inflammation
plays
pivotal
role
in
its
pathologenesis.
However,
the
detailed
mechanism
through
which
injured
tissues
mediate
skeletal
inflammatory
injury
remains
elusive.
Here,
it
reported
that
hepatocytes
might
secrete
mtDNA‐enriched
extracellular
vesicles
(EVs)
to
trigger
by
activating
cGAS‐STING
pathway.
Briefly,
secreted
increased
amounts
EVs
into
circulation,
are
then
engulfed
primarily
macrophages
subsequently
induce
signaling
its‐mediated
response
muscles.
In
contrast,
suppression
hepatic
EV
secretion
or
STING
significantly
alleviated
cirrhosis‐induced
vivo.
Circulating
from
cirrhotic
patients
showed
higher
levels
mtDNA,
EV‐mtDNA
positively
correlated
with
severity
injury.
hepatocytes,
mitochondrial
damage
promoted
release
cytosolic
mtDNA
subsequent
EVs.
This
study
reveals
hepatocyte‐derived
via
mtDNA‒STING
axis,
while
targeted
blockade
represents
potential
therapeutic
approach
for
preventing
cirrhosis‐associated
atrophy.
Language: Английский
Extracellular vesicle-mediated bidirectional communication between the liver and other organs: mechanistic exploration and prospects for clinical applications
Wenhui Mo,
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Yunke Peng,
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Yanyi Zheng
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et al.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: March 8, 2025
The
liver,
functioning
as
an
endocrine
organ,
secretes
a
variety
of
substances
that
influence
the
activities
other
body
organs.
Conversely,
molecules
generated
by
organs
such
bone,
gut,
and
adipose
tissue
can
also
impact
liver
function.
Accumulating
evidence
suggests
bidirectional
communication
between
However,
research
on
how
extracellular
vesicles
(EVs),
which
transport
active
molecular
mediators,
contribute
to
this
interorgan
is
still
in
its
nascent
stages.
EVs
are
capable
transporting
functional
molecules,
including
lipids,
nucleic
acids,
proteins,
thereby
affecting
recipient
cells
across
different
at
biological
level.
This
review
examines
role
facilitating
cardiovascular
system,
pancreas,
brain,
lungs,
kidneys,
tissue.
It
explores
their
potential
disease
treatment
highlights
challenges
understanding
EV-mediated
interactions.
contribution
mediator-carrying
two-way
remains
area
ongoing
investigation.
Future
will
provide
more
comprehensive
theoretical
foundation
clarify
precise
mechanisms
governing
organs,
pinpoint
medical
targets,
expand
application
within
realm
precision
medicine.
Language: Английский
Unraveling the Metabolic Pathways Between Metabolic-Associated Fatty Liver Disease (MAFLD) and Sarcopenia
Marina Ribas Losasso,
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Maria Luiza Cesto Parussolo,
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Antony Oliveira Silva
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et al.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(10), P. 4673 - 4673
Published: May 14, 2025
Metabolic-Associated
Fatty
Liver
Disease
(MAFLD)
is
a
public
health
concern
that
constantly
expanding,
with
fast-growing
prevalence,
and
it
affects
about
quarter
of
the
world's
population.
This
condition
significant
risk
factor
for
cardiovascular,
hepatic,
oncologic
diseases,
such
as
hypertension,
hepatoma,
atherosclerosis.
Sarcopenia
was
long
considered
to
be
an
aging-related
syndrome,
but
today,
acknowledged
secondarily
related
chronic
diseases
metabolic
cardiovascular
conditions,
liver
among
other
comorbidities
associated
insulin
resistance
inflammation,
besides
inactivity
poor
nutrition.
The
physiopathology
involving
MAFLD
sarcopenia
has
still
not
been
solved.
Inflammation,
oxidative
stress,
mitochondrial
dysfunction,
seem
some
keys
this
relationship
since
hormone
target
mainly
skeletal
muscle.
review
aimed
comprehensively
discuss
main
physiological
pathways
involved
in
these
conditions.
are
interconnected
by
complex
network
pathophysiological
mechanisms,
resistance,
muscle
tissue
production
capacity,
inflammatory
state,
which
contributors
relationship.
In
addition,
clinical
analysis,
patients
manifest
more
severe
hepatitis
fibrosis
when
compared
only
MAFLD.
These
patients,
both
disorders,
also
present
improvement
their
treated
sarcopenia,
reinforcing
association
between
them.
Lifestyle
changes
accompanied
non-pharmacological
interventions,
dietary
therapy
increased
physical
activity,
undoubtedly
improve
scenario.
Language: Английский