Bioactive Materials Facilitate the Restoration of Neurological Function Post Cerebral Ischemic Stroke DOI Creative Commons
Chunyan Wang, Chao Sun, Zhaoping Ding

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 14171 - 14191

Published: Dec. 1, 2024

Language: Английский

ALPK1 signaling pathway activation by HMGB1 drives microglial pyroptosis and ferroptosis and brain injury after acute ischemic stroke DOI

Ou Du,

Yu Yan,

Huan Yang

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 149, P. 114229 - 114229

Published: Feb. 10, 2025

Language: Английский

Citations

0
Dicoumarol sensitizes hepatocellular carcinoma cells to ferroptosis induced by imidazole ketone erastin DOI Creative Commons
Ziwei Yang,

Tixin Han,

Ruibin Yang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 11, 2025

Ferroptosis, an iron-dependent form of regulated cell death, is characterized by the lethal accumulation lipid peroxides on cellular membranes. It not only inhibits tumor growth but also enhances immunotherapy responses and overcomes drug resistance in cancer therapy. The inhibition cystine-glutamate antiporter, system Xc-, induces ferroptosis. Imidazole ketone erastin (IKE), inhibitor Xc- functional subunit solute carrier family 7 member 11 (SLC7A11), effective metabolically stable inducer ferroptosis with potential vivo applications. However, cells exhibited differential sensitivity to IKE-induced intrinsic factors determining remain be explored improve its efficacy. Bulk RNA-sequencing data from hepatocellular carcinoma (HCC) normal liver tissues were collected Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) databases. Differentially expressed genes identified intersected ferroptosis-related (FRGs) listed FerrDb database, yielding identification 13 distinct FRGs. A signature index model (Risk Score) was developed predict HCC prognosis. And SLC7A11 NAD(P)H quinone dehydrogenase 1 (NQO1) as candidate FRGs indicating poor prognosis HCC. Dicoumarol (DIC), NQO1, subsequently employed assess sensitizing effects IKE treatment. In lines subcutaneous xenograft model, combined suppression NQO1 significantly enhanced inhibitory effect inducing conclusion, our findings demonstrate that DIC sensitized Moreover, drugs enhance susceptibility could provide novel therapeutic strategies for treatment

Language: Английский

Citations

0
Blood-brain barrier repair: potential and challenges of stem cells and exosomes in stroke treatment DOI Creative Commons
Xiaochen Fu, Jia Li, Shilin Yang

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: April 7, 2025

Stroke is characterized with high morbidity, mortality and disability all over the world, one of its core pathologies blood-brain barrier (BBB) dysfunction. BBB plays a crucial physiological role in protecting brain tissues maintaining homeostasis central nervous system (CNS). dysfunction serves as key factor development cerebral edema, inflammation, further neurological damage stroke patients. Currently, stem cells their derived exosomes have shown remarkable potential repairing damaged improving function after stroke. Stem repair integrity through anti-inflammatory, antioxidant, angiogenesis regulation intercellular signaling mechanisms, while cell-derived exosomes, natural nanocarriers, enhance therapeutic effect by carrying active substances such proteins, RNAs miRNAs. This review will present latest research advances treatment, well challenges cell source, transplantation timing, dosage, route administration clinical application, aiming to discuss mechanisms for proposes future directions. are expected provide new strategies early diagnosis precise treatment stroke, promote breakthroughs field

Language: Английский

Citations

0
Dapagliflozin activates the RAP1B/NRF2/GPX4 signaling and promotes mitochondrial biogenesis to alleviate vascular endothelial ferroptosis DOI
Yi Zhu, Jin Yang, Jiali Zhang

et al.

Cellular Signalling, Journal Year: 2025, Volume and Issue: 132, P. 111824 - 111824

Published: April 23, 2025

Language: Английский

Citations

0
Sepsis-Induced Endothelial Dysfunction: Permeability and Regulated Cell Death DOI Creative Commons

Wei Zhang,

Luofeng Jiang, Xirui Tong

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 9953 - 9973

Published: Nov. 1, 2024

Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection. Endothelial cells (ECs) are an important cell type typically affected in sepsis, resulting compromised barrier function and various forms of regulated death (RCD). However, the precise mechanisms underlying sepsis-induced EC damage remain unclear. This review summarizes recent research progress on factors that may affect permeability RCD ECs under septic conditions, including glycocalyx, damage-associated molecular patterns, ECs, such as apoptosis, pyroptosis, ferroptosis, autophagy. offers insights into endothelial aiming contribute developing small-molecule targeted clinical therapies.

Language: Английский

Citations

0
Bioactive Materials Facilitate the Restoration of Neurological Function Post Cerebral Ischemic Stroke DOI Creative Commons
Chunyan Wang, Chao Sun, Zhaoping Ding

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 14171 - 14191

Published: Dec. 1, 2024

Language: Английский

Citations

0