Pharmacologic Ascorbate Resistant Pancreatic Cancer Demonstrates Enhanced Metastatic Potential

Published: Jan. 1, 2025

Language: Английский

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Crosstalk between Calcium and Reactive Oxygen Species Signaling in Cancer Revisited

Cell Calcium, Journal Year: 2025, Volume and Issue: unknown, P. 103014 - 103014

Published: March 1, 2025

Language: Английский

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Risk comparison of adverse reactions between gemcitabine monotherapy and gemcitabine combined with albumin-bound paclitaxel in pancreatic cancer: insights from the FDA Adverse Event Reporting System (FAERS) database

BMC Pharmacology and Toxicology, Journal Year: 2025, Volume and Issue: 26(1)

Published: March 19, 2025

Pancreatic cancer (PC) is a highly aggressive malignancy with limited treatment options. Although gemcitabine monotherapy (G treatment) has long been standard treatment, combination therapies, such as albumin-bound paclitaxel (AG treatment), have shown improved outcomes and were approved by the FDA for PC. However, AG also associated increased adverse events (AEs), which remain inadequately evaluated in real-world settings. We utilized Adverse Event Reporting System (FAERS) to conduct large-scale pharmacovigilance analysis comparing safety profiles of G treatments By analyzing event data from third quarter 2013 second 2024 quantifying AE signals reporting odds ratio (ROR) proportional (PRR) methods, we compared risk AEs between groups. Time onset (TTO), subgroup logistic regression analyses performed. The study revealed higher proportion male (n = 2307, 54.1%) elderly patients (age ≥ 65years, n 2172, 50.9%) group group. found 17 preferred terms positive at top 50 common AEs, especially gastrointestinal blood systems. Cardiac neurological needed be vigilant. Biliary sepsis infectious enterocolitis newly identified deserve attention. Median TTO was 34 (IQR: 8-103) days (G) 41 10–104) (AG), most occurring within first month (48.3% 44%). Subgroup that using had highest immune-mediated hepatitis (ROR 23.51, 95% CI 3.21–172.1), while elevated risks presyncope 24.84, 3.40–181.28) falls 18.60, 2.53–136.97). Logistic showed higher-risk fatal males (adjusted OR 1.42, 1.15–1.76, P < 0.01) 1.36, 1.10–1.69, 0.01). This research offers critical insights settings, emphasizing heightened informing clinical decision-making PC treatment.

Language: Английский

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The physiological functions of ascorbate in the development of cancer

Disease Models & Mechanisms, Journal Year: 2025, Volume and Issue: 18(4)

Published: April 1, 2025

ABSTRACT The metabolite ascorbate (vitamin C) is synthesized endogenously in most animals or, humans and some other species, obtained from the diet. Its role cancer development controversial. Addition of to cultured cells or high-dose administration can inhibit growth many cancers, but these effects are caused by non-physiological biochemical activities. Few experiments have tested physiological roles depleting it settings. Ascorbate depletion inhibits activity ten-eleven translocation (TET) enzymes hematopoietic leukemia accelerates myeloid development. Many clinical trials supplementation cancers shown little no evidence that has a beneficial role. I propose needed define which role, establish its cellular molecular targets, provide rationale for trials.

Language: Английский

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Nano-drug codelivery system of vincristine and gemcitabine loaded hyaluronan-altered hollow mesoporous silica nanoparticles: investigation of in vitro drug release and anticancer activity in pancreatic cancer cells

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Language: Английский

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