Structure-guided identification of potential MTH1 inhibitors from natural compounds: toward therapeutic targeting of oxidative DNA damage in cancer

Chemical Papers, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Language: Английский

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Modulation of OGG1 enzymatic activities by small molecules, promising tools and current challenges.

DNA repair, Journal Year: 2025, Volume and Issue: 149, P. 103827 - 103827

Published: March 16, 2025

Oxidative DNA damage, resulting from endogenous cellular processes and external sources plays a significant role in mutagenesis, cancer progression, the pathogenesis of neurological disorders. Base Excision Repair (BER) is involved repair base modifications such as oxidations or alkylations well single strand breaks. The glycosylase OGG1, initiates BER pathway by recognition excision 8oxoG, most common oxidative lesion, both nuclear mitochondrial DNA. Beyond repair, OGG1 modulates transcription, particularly pro-inflammatory genes, linking damage to broader biological like inflammation aging. In therapy, inhibition has emerged promising strategy enhance treatment efficacy. Targeting sensitizes cells chemotherapies, radiotherapies, PARP inhibitors, presenting opportunities overcome therapy resistance. Additionally, activators hold potential mitigating associated with aging This review presents development several inhibitors how they have contributed advance our knowledge fundamental functions OGG1. We also discuss new provide for clinical applications treating cancer, Finally, we highlight challenges targeting regarding off-target effects recently reported some can these limitations.

Language: Английский

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Unravelling the epigenetic based mechanism in discovery of anticancer phytomedicine: Evidence based studies

Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111743 - 111743

Published: March 1, 2025

Language: Английский

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Antioxidants in cancer therapy mitigating lipid peroxidation without compromising treatment through nanotechnology

Discover Nano, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 24, 2025

Cancer treatments often exploit oxidative stress to selectively kill tumour cells by disrupting their lipid peroxidation membranes and inhibiting antioxidant enzymes. However, plays a dual role in cancer progression, acting as both promoter suppressor. Balancing through therapy remains challenge, excessive activity may compromise the efficacy of chemotherapy radiotherapy. This review explores antioxidants mitigating while maintaining treatment efficacy. It highlights recent advancements nanotechnology-based targeted delivery optimize therapeutic outcomes. A comprehensive literature was conducted using reputable databases, including PubMed, Scopus, Web Science, ScienceDirect. The search focused on publications from past five years (2020-2025), supplemented relevant studies earlier years. Keywords such "antioxidants," "lipid peroxidation," "nanotechnology therapy," "oxidative stress" were utilized. Relevant articles critically analysed, graphical illustrations created. Emerging evidence suggests that nanoparticles, liposomes, polymeric metal-organic frameworks, others, can effectively encapsulate control release minimizing systemic toxicity. Stimuli-responsive carriers with tumour-specific targeting mechanisms further enhance delivery. Studies indicate these strategies help preserve normal cells, mitigate stress-related damage, improve challenges bioavailability, stability, potential interactions standard therapies remain. Integrating nanotechnology antioxidant-based interventions presents promising approach for optimizing therapy. Future research should focus refining modulation strategies, assessing profiles during treatment, employing biomarkers determine optimal dosing. balanced use adverse effects.

Language: Английский

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A triple-cascade nanoreactor for potent anti-tumor chemodynamic and immunotherapy

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 253, P. 114732 - 114732

Published: April 24, 2025

Language: Английский

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Phytochemical composition, in vitro cytotoxicity and in silico ADME/Tox analysis of the active compounds of Oxalis latifolia Kunth. extracts with promising anticancer potential

3 Biotech, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 20, 2024

Language: Английский

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