Leucine‐Rich Repeat‐Containing G Protein‐Coupled Receptor 6 Ameliorates Pressure Overload‐Induced Cardiac Hypertrophy by Regulating Cardiomyocyte Metabolic Reprogramming DOI Creative Commons
Mengmeng Zhao, Jianfang Liu, Shanshan Peng

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Abstract Metabolic reprogramming is a pivotal mechanism in the pathogenesis of pathological cardiac hypertrophy. Leucine‐rich repeat‐containing G protein‐coupled receptor 6 (Lgr6) has emerged as significant player cardiovascular diseases. In this study, potential Lgr6 to counteract pressure overload (PO)‐induced hypertrophy investigated, and underlying mechanisms involved are elucidated. Transverse aortic constriction (TAC) induced establish an vivo model. Adeno‐associated virus 9 adenovirus vectors utilized knock down overexpress cardiomyocytes, respectively. The effects its downstream molecules subsequently determined using RNA sequencing chromatin immunoprecipitation. Significant downregulation expression observed heart after TAC cardiomyocytes treated with phenylephrine. deficiency accelerated overexpression inhibits dysfunction TAC. Mechanistically, vitro experiments suggest that regulates ubiquitin specific protease 4 (USP4) peroxisome proliferator‐activated alpha (PPARα) by activating cGMP/PKG/CREB1 signalling pathway, thereby regulating cardiomyocyte metabolic PO. Targeting can be therapeutic strategy treat

Language: Английский

Necroptosis in myocardial ischaemia-reperfusion injury: current update on mechanisms, therapeutic targets, and translational potential DOI
Siarhei A. Dabravolski, Vladislav Kalmykov,

Anastasia O Maksaeva

et al.

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Language: Английский

Citations

0
Leucine‐Rich Repeat‐Containing G Protein‐Coupled Receptor 6 Ameliorates Pressure Overload‐Induced Cardiac Hypertrophy by Regulating Cardiomyocyte Metabolic Reprogramming DOI Creative Commons
Mengmeng Zhao, Jianfang Liu, Shanshan Peng

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Abstract Metabolic reprogramming is a pivotal mechanism in the pathogenesis of pathological cardiac hypertrophy. Leucine‐rich repeat‐containing G protein‐coupled receptor 6 (Lgr6) has emerged as significant player cardiovascular diseases. In this study, potential Lgr6 to counteract pressure overload (PO)‐induced hypertrophy investigated, and underlying mechanisms involved are elucidated. Transverse aortic constriction (TAC) induced establish an vivo model. Adeno‐associated virus 9 adenovirus vectors utilized knock down overexpress cardiomyocytes, respectively. The effects its downstream molecules subsequently determined using RNA sequencing chromatin immunoprecipitation. Significant downregulation expression observed heart after TAC cardiomyocytes treated with phenylephrine. deficiency accelerated overexpression inhibits dysfunction TAC. Mechanistically, vitro experiments suggest that regulates ubiquitin specific protease 4 (USP4) peroxisome proliferator‐activated alpha (PPARα) by activating cGMP/PKG/CREB1 signalling pathway, thereby regulating cardiomyocyte metabolic PO. Targeting can be therapeutic strategy treat

Language: Английский

Citations

0