Adenosine triphosphate-induced cell death in heart failure: Is there a link? DOI
Jingjing Zhang, Lu Cheng, Qian Qiao

et al.

World Journal of Cardiology, Journal Year: 2025, Volume and Issue: 17(4)

Published: April 21, 2025

Heart failure (HF) has emerged as one of the foremost global health threats due to its intricate pathophysiological mechanisms and multifactorial etiology. Adenosine triphosphate (ATP)-induced cell death represents a novel form regulated deaths, marked by cellular energy depletion metabolic dysregulation stemming from excessive ATP accumulation, identifying uniqueness compared other processes modalities such programmed necrosis. Growing evidence suggests that ATP-induced (AICD) is predominantly governed various biological pathways, including metabolism, redox homeostasis intracellular calcium equilibrium. Recent research shown AICD crucial in HF induced pathological conditions like myocardial infarction, ischemia-reperfusion injury, chemotherapy. Thus, it essential investigate function pathogenesis HF, this may provide foundation for development targeted therapies treatment strategies. This review synthesizes current advancements understanding link between while further elucidating involvement cardiac remodeling progression.

Language: Английский

Roles of Autophagy, Mitophagy, and Mitochondria in Left Ventricular Remodeling after Myocardial Infarction DOI Creative Commons

Xin Zhang,

Shuai Shao,

Qiuting Li

et al.

Reviews in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 26(3)

Published: March 24, 2025

This review examines the mechanisms of left ventricular dysfunction, focusing on interplay between remodeling, autophagy, and mitochondrial dysfunction following myocardial infarction. Left directly affects heart's pumping efficiency can lead to severe clinical outcomes, including heart failure. After infarction, ventricle may suffer from weakened contractility, diastolic cardiac progressing Thus, this article discusses pathophysiological processes involved in injury repair infarcted non-infarcted myocardia, adaptive changes, specific changes systolic functions. Furthermore, role autophagy maintaining cellular energy homeostasis, clearing dysfunctional mitochondria, key failure is addressed. Finally, therapeutic strategies targeting enhancing mitophagy, providing clinicians researchers with latest insights future research directions.

Language: Английский

Citations

0
Adenosine triphosphate-induced cell death in heart failure: Is there a link? DOI
Jingjing Zhang, Lu Cheng, Qian Qiao

et al.

World Journal of Cardiology, Journal Year: 2025, Volume and Issue: 17(4)

Published: April 21, 2025

Heart failure (HF) has emerged as one of the foremost global health threats due to its intricate pathophysiological mechanisms and multifactorial etiology. Adenosine triphosphate (ATP)-induced cell death represents a novel form regulated deaths, marked by cellular energy depletion metabolic dysregulation stemming from excessive ATP accumulation, identifying uniqueness compared other processes modalities such programmed necrosis. Growing evidence suggests that ATP-induced (AICD) is predominantly governed various biological pathways, including metabolism, redox homeostasis intracellular calcium equilibrium. Recent research shown AICD crucial in HF induced pathological conditions like myocardial infarction, ischemia-reperfusion injury, chemotherapy. Thus, it essential investigate function pathogenesis HF, this may provide foundation for development targeted therapies treatment strategies. This review synthesizes current advancements understanding link between while further elucidating involvement cardiac remodeling progression.

Language: Английский

Citations

0