Sulforaphane and Brain Health: From Pathways of Action to Effects on Specific Disorders DOI Open Access
Jed W. Fahey, Hua Liu,

Holly Batt

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1353 - 1353

Published: April 15, 2025

The brain accounts for about 2% of the body’s weight, but it consumes 20% energy at rest, primarily derived from ATP produced in mitochondria. thus has a high mitochondrial density its neurons because extensive demands maintaining ion gradients, neurotransmission, and synaptic activity. is also extremely susceptible to damage dysregulation caused by inflammation (neuroinflammation) oxidative stress. Many systemic challenges can be mitigated phytochemical sulforaphane (SF), which particularly important supporting function. SF or biogenic precursor glucoraphanin, broccoli seeds sprouts, confer neuroprotective cognitive benefits via diverse physiological biochemical mechanisms. able cross blood–brain barrier as well protect it, mitigates consequences destructive neuroinflammation. It protects against neurotoxic effects environmental pollutants, combats tissue cell wrought advanced glycation end products (detoxication), supports healthy glucose metabolism. These are applicable individuals all ages, developing brains periconception infancy, cognitively, developmentally, traumatically challenged brains, those later life who suffering with multiple chronic conditions including Parkinson’s Alzheimer’s diseases.

Language: Английский

Sulforaphane and Brain Health: From Pathways of Action to Effects on Specific Disorders DOI Open Access
Jed W. Fahey, Hua Liu,

Holly Batt

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1353 - 1353

Published: April 15, 2025

The brain accounts for about 2% of the body’s weight, but it consumes 20% energy at rest, primarily derived from ATP produced in mitochondria. thus has a high mitochondrial density its neurons because extensive demands maintaining ion gradients, neurotransmission, and synaptic activity. is also extremely susceptible to damage dysregulation caused by inflammation (neuroinflammation) oxidative stress. Many systemic challenges can be mitigated phytochemical sulforaphane (SF), which particularly important supporting function. SF or biogenic precursor glucoraphanin, broccoli seeds sprouts, confer neuroprotective cognitive benefits via diverse physiological biochemical mechanisms. able cross blood–brain barrier as well protect it, mitigates consequences destructive neuroinflammation. It protects against neurotoxic effects environmental pollutants, combats tissue cell wrought advanced glycation end products (detoxication), supports healthy glucose metabolism. These are applicable individuals all ages, developing brains periconception infancy, cognitively, developmentally, traumatically challenged brains, those later life who suffering with multiple chronic conditions including Parkinson’s Alzheimer’s diseases.

Language: Английский

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