Childhood atopic disorders in relation to placental changes—A systematic review and meta‐analysis DOI Creative Commons

Zaki Bakoyan,

Yang Cao, Stefan R. Hansson

et al.

Pediatric Allergy and Immunology, Journal Year: 2024, Volume and Issue: 35(5)

Published: May 1, 2024

Abstract Fetal programming may arise from prenatal exposure and increase the risk of diseases later in life, potentially mediated by placenta. The objective this systematic review was to summarize critically evaluate publications describing associations between human placental changes atopic disorders during childhood. adhered Preferred Reporting Items for Systematic Reviews Meta‐analysis guidelines. inclusion criteria were original research articles or case reports written English a change relation disease occurring offspring MEDLINE EMBASE databases searched eligible studies. Risk bias (RoB) assessed using ROBINS‐I tool. results pooled both narrative way meta‐analysis. Nineteen studies included ( n = 12,997 participants). All had an overall serious RoB, publication could not be completely ruled out. However, five showed that histological chorioamnionitis preterm‐born children associated with asthma‐related problems (pooled odds ratio 3.25 (95% confidence interval 2.22–4.75)). In term‐born children, large placenta (≥750 g) increased being prescribed anti‐asthma medications first year life. Placental histone acetylation, DNA methylation, gene expression differences found different children. There is some evidence supporting idea can mediate further are needed validate findings, properly control confounders, examine potential mechanisms.

Language: Английский

Uteroplacental Adaptations to an Altered Gestational Environment: Advances in Clinical, Animal Model and In Vitro Studies DOI
Jayanth Ramadoss, Michael C. Petriello, M. S. Chauhan

et al.

Reproductive Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 108900 - 108900

Published: March 1, 2025

Language: Английский

Citations

0
Childhood atopic disorders in relation to placental changes—A systematic review and meta‐analysis DOI Creative Commons

Zaki Bakoyan,

Yang Cao, Stefan R. Hansson

et al.

Pediatric Allergy and Immunology, Journal Year: 2024, Volume and Issue: 35(5)

Published: May 1, 2024

Abstract Fetal programming may arise from prenatal exposure and increase the risk of diseases later in life, potentially mediated by placenta. The objective this systematic review was to summarize critically evaluate publications describing associations between human placental changes atopic disorders during childhood. adhered Preferred Reporting Items for Systematic Reviews Meta‐analysis guidelines. inclusion criteria were original research articles or case reports written English a change relation disease occurring offspring MEDLINE EMBASE databases searched eligible studies. Risk bias (RoB) assessed using ROBINS‐I tool. results pooled both narrative way meta‐analysis. Nineteen studies included ( n = 12,997 participants). All had an overall serious RoB, publication could not be completely ruled out. However, five showed that histological chorioamnionitis preterm‐born children associated with asthma‐related problems (pooled odds ratio 3.25 (95% confidence interval 2.22–4.75)). In term‐born children, large placenta (≥750 g) increased being prescribed anti‐asthma medications first year life. Placental histone acetylation, DNA methylation, gene expression differences found different children. There is some evidence supporting idea can mediate further are needed validate findings, properly control confounders, examine potential mechanisms.

Language: Английский

Citations

0