Protective Effects of Diospyros Kaki Leaves Extract against Oxidative Damage and Inflammation in the Testicular Ischemia-Reperfusion Model in Rats DOI Creative Commons
Ziya Yurtal, Kadri Kulualp, Hüseyin Özkan

et al.

Indian Journal of Experimental Biology, Journal Year: 2023, Volume and Issue: 61(11)

Published: Nov. 1, 2023

Protective effect of Diospyros Kaki leaves extract against oxidative damage and inflammation in the testicular ischemia-reperfusion model were investigated study. 32 male rats randomly equally divided into 4 groups. While saline (SF) was given to control ischemia/reperfusion (I/R) groups for 5 days, (DK) I/R+DK 200 mg/kg DK leaf extract. Afterwards, left orchiectomy performed DK, torsion I/R 2 hours. All sacrificed 24 hours after procedures samples collected. Compared control, had high MDA levels, low GSH GSH-Px levels; compared I/R, levels lower, higher. In presence congestion hemorrhage determined deterioration seminiferous tubule structure spermatogenesis less I/R+DK. TNF-α, COX-2, BCL-2, BAX genes expressions significantly lower TNF-α COX-2 proteins higher I/R+DK, while NRF2 These results show has crucial protective rats.

Language: Английский

The Role of Environmental Endocrine Disruptors on Leydig Cell Death and Senescen DOI Creative Commons
Fang Yang,

Xiaoya Li,

M.-Y. Wang

et al.

The World Journal of Men s Health, Journal Year: 2025, Volume and Issue: 43

Published: Jan. 1, 2025

Environmental endocrine disruptors, as exogenous chemicals that interfere with hormonal behavior, are known to cause testicular Leydig cell death and senescence. The incidence of diseases the male reproductive system has been increasing over past half-century. Genetic defects alone cannot explain rapid increase in incidence, there is growing evidence environmental factors or lifestyle changes responsible for high recent years. Testicular cells occupy an important role system. In this study, we review mechanisms by which disruptors promote both senescence cells, refine former into two programmed modes, apoptosis, autophagy, further explore interactions among them, thus summarizing advances toxic effects on expecting provide a new therapeutic idea.

Language: Английский

Citations

0
Carvacrol attenuates varicocele-induced infertility in rats DOI

Elham Ghahreman,

Akram Eidi, Pejman Mortazavi

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177303 - 177303

Published: Jan. 1, 2025

Language: Английский

Citations

0
Bisphenol AF Caused Reproductive Toxicity in Rats and Cineole Co-Treatment Exhibited Protective Effect DOI
Ahmet Uyar, Mustafa Cellat, Özgür Kanat

et al.

Reproductive Sciences, Journal Year: 2024, Volume and Issue: 31(11), P. 3462 - 3474

Published: Aug. 19, 2024

Language: Английский

Citations

1
Neuroprotective effects of Sideritis trojana essential oil in AlCl 3 -induced amnesic rats DOI
Şükrü Hayta, Özgür Bulmuş, Elif Aksöz

et al.

Journal of Essential Oil Bearing Plants, Journal Year: 2024, Volume and Issue: 27(4), P. 1035 - 1048

Published: July 3, 2024

AbstractIn this study, the effects of Sideritis trojana essential oil on memory, anxiety, and depression were investigated in rats subjected to AlCl3-induced dementia. The major constituents S. analyzed as carvacrol (42.32%), carvone (18.69%), α-pinene (4.54%). Rats divided into five groups: Control, positive control (donepezil), AlCl3-only applicated, AlCl3 with 40% 80% applicated groups. was administered for 30 days, after that, behavioral tests. In forced swimming test, application demonstrated antidepressant-like effects. elevated plus maze open field tests, exhibited anxiolytic-like Furthermore, ameliorated memory impairment induced by increasing spontaneous alternation Y-maze test. reduced level malondialdehyde increased catalase activity, demonstrating antioxidant activity. Molecular docking analyses performed between compounds AMPA receptor evaluate possible mechanisms action leading neuroprotection. Carvacrol, carvone, shown possess strong binding abilities receptor, which may result allosteric modulation receptor. This study neuroprotective an animal model application, suggesting its potential protective role against central nervous system disorders.Keywords: oilAluminum chlorideAlzheimer's DiseaseCarvacrolMemory Supplementary DataFigures S1 S2 are provided supplementary file.

Language: Английский

Citations

0
Effects of different drying methods on phytochemical quality and microbial load of Satureja spicigera DOI

Mahdieh Jafari Ghoshchi,

Bohloul Abbaszadeh,

Mehdi Oraei

et al.

Journal of Essential Oil Bearing Plants, Journal Year: 2024, Volume and Issue: 27(5), P. 1347 - 1361

Published: Sept. 2, 2024

Language: Английский

Citations

0
Ameliorative impacts of carvacrol on DNA integrity, oxidative stress, and sperm quality in asthenozoospermic infertile individuals during cryopreservation DOI
Ebrahim Cheraghi, Seyed Mohammad Ali Shariatzadeh,

Fatemeh Hajiazimi

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 16, 2024

Language: Английский

Citations

0
Protective Effects of Diospyros Kaki Leaves Extract against Oxidative Damage and Inflammation in the Testicular Ischemia-Reperfusion Model in Rats DOI Creative Commons
Ziya Yurtal, Kadri Kulualp, Hüseyin Özkan

et al.

Indian Journal of Experimental Biology, Journal Year: 2023, Volume and Issue: 61(11)

Published: Nov. 1, 2023

Protective effect of Diospyros Kaki leaves extract against oxidative damage and inflammation in the testicular ischemia-reperfusion model were investigated study. 32 male rats randomly equally divided into 4 groups. While saline (SF) was given to control ischemia/reperfusion (I/R) groups for 5 days, (DK) I/R+DK 200 mg/kg DK leaf extract. Afterwards, left orchiectomy performed DK, torsion I/R 2 hours. All sacrificed 24 hours after procedures samples collected. Compared control, had high MDA levels, low GSH GSH-Px levels; compared I/R, levels lower, higher. In presence congestion hemorrhage determined deterioration seminiferous tubule structure spermatogenesis less I/R+DK. TNF-α, COX-2, BCL-2, BAX genes expressions significantly lower TNF-α COX-2 proteins higher I/R+DK, while NRF2 These results show has crucial protective rats.

Language: Английский

Citations

0