Effect of Aflatoxin B1 on the Nervous System: A Systematic Review and Network Analysis Highlighting Alzheimer’s Disease DOI Creative Commons

Samira Ranjbar,

Pantea Mohammadi,

Somayeh Pashaei

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 436 - 436

Published: April 17, 2025

Exposure to aflatoxin (AF) triggers the production of inflammatory molecules and free radicals, leading chronic inflammation, cancer, neurodegenerative diseases. This systematic review evaluated effects AFB1 on nervous system, particularly focusing Alzheimer’s disease (AD). A comprehensive search was conducted in Scopus, Cochrane Library, PubMed, Web Science databases up 1 June 2024, without restrictions. From 993 records retrieved, 16 articles were included review. participates various biochemical processes pathological conditions. The study highlights that contributes AD by inducing DNA damage, oxidative stress, endoplasmic reticulum (ER) impairing repair mechanisms. results neuronal cognitive decline, neurodegeneration. also affects key signaling pathways, reduces sodium–potassium pump activity, disrupts cell cycle regulation involving p53, neurotoxicity, formation amyloid-beta (Aβ) plaques neurofibrillary tangles. Additionally, network analysis revealed 309 genes associated with AD, angiopathy, B1 (AFB1). Among these, ESR1 exhibited highest number direct connections other nodes within network. gene TP53 played a pivotal role mediating communication among genes, while EP300 significantly influenced overall structure. KEGG enrichment demonstrated these are substantially involved pathways related FoxO pathway, apoptosis, AD. In summary, causes damage decline It damages neurons, repair, contributing neurotoxicity inflammation. PROSPERO registration number: CRD420250651007.

Language: Английский

Effect of Aflatoxin B1 on the Nervous System: A Systematic Review and Network Analysis Highlighting Alzheimer’s Disease DOI Creative Commons

Samira Ranjbar,

Pantea Mohammadi,

Somayeh Pashaei

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 436 - 436

Published: April 17, 2025

Exposure to aflatoxin (AF) triggers the production of inflammatory molecules and free radicals, leading chronic inflammation, cancer, neurodegenerative diseases. This systematic review evaluated effects AFB1 on nervous system, particularly focusing Alzheimer’s disease (AD). A comprehensive search was conducted in Scopus, Cochrane Library, PubMed, Web Science databases up 1 June 2024, without restrictions. From 993 records retrieved, 16 articles were included review. participates various biochemical processes pathological conditions. The study highlights that contributes AD by inducing DNA damage, oxidative stress, endoplasmic reticulum (ER) impairing repair mechanisms. results neuronal cognitive decline, neurodegeneration. also affects key signaling pathways, reduces sodium–potassium pump activity, disrupts cell cycle regulation involving p53, neurotoxicity, formation amyloid-beta (Aβ) plaques neurofibrillary tangles. Additionally, network analysis revealed 309 genes associated with AD, angiopathy, B1 (AFB1). Among these, ESR1 exhibited highest number direct connections other nodes within network. gene TP53 played a pivotal role mediating communication among genes, while EP300 significantly influenced overall structure. KEGG enrichment demonstrated these are substantially involved pathways related FoxO pathway, apoptosis, AD. In summary, causes damage decline It damages neurons, repair, contributing neurotoxicity inflammation. PROSPERO registration number: CRD420250651007.

Language: Английский

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