Curcumin ameliorates dichlorvos-induced cardiac injury by suppressing oxidative stress and downregulating pro-inflammatory cytokines in male Wistar rats

Scientific African, Journal Year: 2025, Volume and Issue: unknown, P. e02711 - e02711

Published: April 1, 2025

Language: Английский

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Effect of in vitro exposure of first-line antiretrovirals on healthy human spermatozoa on kinematics and motility

International Urology and Nephrology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Abstract Purpose Contemporary antiretroviral (ARV) medications are used by millions of men for HIV treatment worldwide. Limited data exist on their direct effect sperm motility. This pilot study hypothesizes that in vitro exposure to ARVs will reduce kinematic and motility parameter values. Methods laboratory-based experimental analyzed kinematics after the Dolutegravir, Tenofovir, Emtricitabine, individually combination. Each participant (n = 23) served as control. The Microptic SCA® Computer Assisted Sperm Analysis (CASA) system, Barcelona, Spain was generate quantitative Straight-line velocity (VSL), Straightness index (STR), Linearity Index (LIN), Beat cross frequency (BCF), oscillation (WOB). Results VSL, STR, LIN, WOB non-progressive (grade c) spermatozoa were significantly decreased ARV treatment. BCF medium progressive population b) increased 90 min Tenofovir arm, a significant decrease proportion grade b recorded at all arms when compared control arm. No impaired observed within first 30 exposure. Conclusion Pharmacovigilance is healthcare emergency fast-changing world newer drugs leaves clinicians vulnerable. They must prescribe whose long-term somatic germline adverse effects not fully understood. Guidelines changing faster than we can monitor side effects. Despite Dolutegravir being only mainstream integrase inhibitor first-line South Africa five years, its replacement, Cabotegravir, already launched. More research this field required, especially commonly prescribed drugs. preliminary concludes current patients HIV-negative pre-exposure prophylaxis (PrEP) alter kinematics. Further with larger sample size warranted quantify impact human fertility, addressing limitations study, before comprehensive conclusion male fertility be drawn. Of particular importance would reactive oxygen species levels semen DNA fragmentation.

Language: Английский

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Ureaplasma urealyticum upregulates seminal fluid leukocytes and lowers human semen quality: a systematic review and meta-analysis

Basic and Clinical Andrology, Journal Year: 2025, Volume and Issue: 35(1)

Published: April 17, 2025

Abstract Background Ureaplasma urealyticum belongs to the class Mollicutes and causes non-gonococcal urethritis, an inflammation of urethra that is linked with impaired semen quality. However, some reports are contradictory, reported effect U. on specific sperm variables not consistent. Thus, this study synthesized findings from published primary data provides a robust reliable inference impact associated mechanisms Methods A systematic search was conducted until 31st May, 2024, Cochrane, Google Scholar, Pubmed. The Population, Exposure, Comparator/Comparison, Outcomes, Study Design (PECOS) model adopted. populations were male in their reproductive ages who infected confirmed positive versus control age-matched non-infected or treated, while outcomes included conventional parameters, seminal fluid leucocyte count, interleukin-6 (IL-6) concentrations, studies either cross-sectional longitudinal. Results When compared control, quantitative analysis demonstrated significantly reduced ejaculate volume (SMD 0.33 [95% CI: 0.15, 0.52] p = 0.0004), concentration 0.47 0.31, 0.64] < 0.00001), total motility 0.73 0.43, 1.02] motile count 0.21 0.17, 0.26] normal morphology 0.88 0.42, 1.35] 0.0002), but increased leukocyte -0.82 -1.61, -0.02] 0.04). In addition, qualitative revealed urealyticum- subjects had higher levels IL-1β, IL-6, IL-8, TNF-α, peroxidase, leukocytes , neutrophils, CD4 + T cells, CD8 cells when control. Furthermore, DNA fragmentation apoptotic observed Conclusions These lowers quality via upregulation leukocytes, elastase, pro-inflammatory cytokines, fragmentation. further required elucidate underlying association between decline develop effective therapies for condition.

Language: Английский

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Editorial: Environmental threats to human reproduction

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 2, 2024

These environmental stressors acts via multiple pathways. First, they disrupt the endocrine system by mimicking or blocking sex hormones (Akhigbe et al., 2022). They may also induce oxidative stress upregulating generation of free radicals and suppressing antioxidants (Kumar 2018;Akhigbe 2021), trigger inflammation immune response (Li 2021;Ashonibare 2024b), promote genotoxicity (Choudhuri 2021) Although SARS-CoV-2 remains quite novel, convincing evidences have been provided on its possible link with infertility Hamed, 2020;Adeyemi 2022)

Language: Английский

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