Human Platelet Extract (Plated) Hair Serum for Hair Health Improvement: A Double-blind, Placebo-controlled Clinical Study DOI Creative Commons

David M. Weir,

Saranya P. Wyles, Atta Behfar

et al.

Plastic & Reconstructive Surgery Global Open, Journal Year: 2025, Volume and Issue: 13(3), P. e6562 - e6562

Published: March 1, 2025

Background: The primary aim of this study was to demonstrate the benefits topical human platelet exosome extract (HPE) (plated) hair serum for improving and scalp health in participants with self-perceived thinning hair. Methods: This single-center, placebo-controlled, double-blind enrolled 39 healthy men women 18–65 years age Participants applied either HPE 9 months or a placebo 6 option cross over at an additional 3 months. End points included improvements global aesthetic appearance hair, as assessed by blinded live evaluator; participant-reported outcomes; trichoscopy; independent physician photograph evaluations. Safety data monitoring adverse events. Results: Blinded evaluator assessments demonstrated statistically significant volume/fullness, density, coverage, appearance, all P values less than 0.0001 within group statistical improvement control coverage. Participant-reported outcomes within-group changes were parameters, including volume fullness, health, thickness, amount, quality, color, dryness, strength, overall Hair trichoscopy analyses significantly improved from baseline group. Independent photography review greater No effects observed. Conclusions: demonstrates that Renewosome technology improves is safe well tolerated.

Language: Английский

Dermal T cell immunity and key regulatory signaling pathways: Implications in immune-mediated alopecia and hair regeneration DOI Creative Commons
Nana Tao, Qingru Sun,

Yuyuan Ying

et al.

Genes & Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 101518 - 101518

Published: Jan. 1, 2025

Language: Английский

Citations

0
Near-infrared light-triggered nitric oxide-releasing hyaluronic acid hydrogel for precision transdermal therapy of androgenic alopecia DOI

Hui Xing,

Yucheng Wang,

Shengling Huang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 304, P. 140751 - 140751

Published: Feb. 6, 2025

Language: Английский

Citations

0
Hair regeneration in androgenetic alopecia using secretome of adipose-derived stem cells (ADSC) and minoxidil: a comparative study of three groups DOI
Lili Legiawati, Irma Bernadette S. Sitohang, Shannaz Nadia Yusharyahya

et al.

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: March 1, 2025

Language: Английский

Citations

0
Exploration of Aloe vera, Centella asiatica, Green Tea, and Pueraria mirifica Extracts in Modulating Stem Cell-Like Properties for Hair Rejuvenation Through β-Catenin Stabilization and Activation of the Akt Signaling Cascade in Human Dermal Papilla Cells DOI Creative Commons
Zin Zin,

Supaporn Barrameesangpet,

Pithi Chanvorachote

et al.

Natural Product Communications, Journal Year: 2025, Volume and Issue: 20(2)

Published: Feb. 1, 2025

Objective: Recent advancements in stem cell biology have revealed the potential of natural active compounds to boost hair growth and prevent loss by enhancing stemness dermal papilla (DP) cells. Methods: The level upstream stabilized β-catenin was assessed using western blot analysis immunofluorescence. determined real-time RT-qPCR examine mRNA factors confirm protein Results: Our cytotoxicity assay on DP cells treated with various extracts, including AV, CA, GT, PM, a combination these extracts (ACGP), indicated no impact viability even at high concentrations (4000 μg/ml). Moreover, ACGP showed 1.5-fold proliferation rate compared single treatment Western increase expression levels both pAkt ACGP-treated results demonstrated that combined (ACGP) exhibited significantly increased OCT4, NANOG, SOX2 40-, 110-, 30-fold, respectively, downstream stabilize pathway for expression. Corresponding also 2-, 3-, 2-fold, each extract individually. Conclusion: These findings synergistic effect products stimulating via their cellular functions.

Language: Английский

Citations

0
Human Platelet Extract (Plated) Hair Serum for Hair Health Improvement: A Double-blind, Placebo-controlled Clinical Study DOI Creative Commons

David M. Weir,

Saranya P. Wyles, Atta Behfar

et al.

Plastic & Reconstructive Surgery Global Open, Journal Year: 2025, Volume and Issue: 13(3), P. e6562 - e6562

Published: March 1, 2025

Background: The primary aim of this study was to demonstrate the benefits topical human platelet exosome extract (HPE) (plated) hair serum for improving and scalp health in participants with self-perceived thinning hair. Methods: This single-center, placebo-controlled, double-blind enrolled 39 healthy men women 18–65 years age Participants applied either HPE 9 months or a placebo 6 option cross over at an additional 3 months. End points included improvements global aesthetic appearance hair, as assessed by blinded live evaluator; participant-reported outcomes; trichoscopy; independent physician photograph evaluations. Safety data monitoring adverse events. Results: Blinded evaluator assessments demonstrated statistically significant volume/fullness, density, coverage, appearance, all P values less than 0.0001 within group statistical improvement control coverage. Participant-reported outcomes within-group changes were parameters, including volume fullness, health, thickness, amount, quality, color, dryness, strength, overall Hair trichoscopy analyses significantly improved from baseline group. Independent photography review greater No effects observed. Conclusions: demonstrates that Renewosome technology improves is safe well tolerated.

Language: Английский

Citations

0