medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Dec. 1, 2023
ABSTRACT
Space
medicine
is
a
vital
discipline
with
often
time-intensive
and
costly
projects
constrained
opportunities
for
studying
various
elements
such
as
space
missions,
astronauts,
simulated
environments.
Moreover,
private
interests
gain
increasing
influence
in
this
discipline.
In
scientific
disciplines
these
features,
transparent
rigorous
methods
are
essential.
Here,
we
undertook
an
evaluation
of
transparency
indicators
publications
within
the
field
medicine.
A
meta-epidemiological
assessment
PubMed
Central
Open
Access
(PMC
OA)
eligible
articles
was
performed
prevalence
code
sharing,
data
pre-registration,
conflicts
interest,
funding.
Text
mining
rtransparent
text
algorithms
manual
validation
200
random
to
obtain
corrected
estimates.
Across
1215
included
articles,
39
(3%)
shared
code,
258
(21%)
data,
10
(1%)
were
registered,
110
(90%)
contained
conflict-of-interest
statement,
1141
(93%)
funding
statement.
After
validation,
estimates
registration
5%,
27%,
1%,
respectively.
Data
sharing
32%
when
limited
original
highest
space/parabolic
flights
(46%).
Overall,
across
observed
modest
rates
rare
almost
non-existent
protocol
registration.
Enhancing
research
imperative
safeguarding
its
rigor
reproducibility.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: April 7, 2024
During
spaceflight,
the
cardiovascular
system
undergoes
remarkable
adaptation
to
microgravity
and
faces
risk
of
cardiac
remodeling.
Therefore,
effects
mechanisms
on
morphology,
physiology,
metabolism,
cellular
biology
need
be
further
investigated.
Since
China
started
constructing
Space
Station
(CSS)
in
2021,
we
have
taken
advantage
Shenzhou-13
capsule
send
human
pluripotent
stem
cell-derived
cardiomyocytes
(hPSC-CMs)
Tianhe
core
module
CSS.
In
this
study,
hPSC-CMs
subjected
space
showed
decreased
beating
rate
abnormal
intracellular
calcium
cycling.
Metabolomic
transcriptomic
analyses
revealed
a
battery
metabolic
remodeling
especially
thiamine
metabolism.
The
condition
blocked
intake
hPSC-CMs.
decline
utilization
under
or
by
its
antagonistic
analog
amprolium
affected
process
tricarboxylic
acid
cycle.
It
ATP
production,
which
led
cytoskeletal
homeostasis
imbalance
More
importantly,
vitro
vivo
studies
suggest
that
supplementation
could
reverse
adaptive
changes
induced
simulated
microgravity.
This
study
represents
first
astrobiological
lays
solid
foundation
for
aerospace
biomedical
research.
These
data
indicate
intervention
thiamine-modified
reprogramming
during
spaceflight
might
feasible
countermeasure
against
npj Microgravity,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: Nov. 6, 2024
The
rising
aging
population
underscores
the
need
for
advances
in
tissue
engineering
and
regenerative
medicine.
Alterations
cellular
response
microgravity
might
be
pivotal
unraveling
intricate
mechanisms
governing
organ
regeneration.
Microgravity
could
improve
multicellular
spheroid,
tissue,
formation.
This
review
summarizes
microgravity-induced
alterations
highlights
potential
of
future
breakthroughs
space
travel,
transplantation,
drug
testing,
personalized
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(2), P. 231 - 231
Published: Feb. 18, 2025
With
the
continued
exploration
of
universe,
there
is
an
increasingly
urgent
need
to
address
health
challenges
arising
from
spaceflight.
In
space,
astronauts
are
exposed
radiation,
confinement
and
isolation,
circadian
rhythm
dysregulation,
microgravity
conditions
that
different
those
on
Earth.
These
risk
factors
jeopardize
astronauts'
health,
thus
affecting
quality
space
missions.
Among
these
factors,
gravitational
changes
influence
balance
between
oxidation
antioxidants,
stimulating
production
reactive
oxygen
species
(ROS),
finally
leading
oxidative
stress
(OS).
OS
leads
damage
biomolecules
such
as
lipids,
proteins,
DNA,
which
causes
development
various
diseases.
The
occurrence
increased
in
affects
multiple
systems,
including
musculoskeletal,
cardiovascular,
nervous,
immune
systems.
this
review,
we
discuss
mechanisms
OS,
physiological
effects
systems
caused
by
environment,
potential
treatments
for
OS.
Finally,
treatment
strategies
summarized,
providing
some
promising
approaches
protecting
future
exploration.
Biofouling,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 19
Published: March 26, 2025
Biofilms
are
common
in
water
systems
and
can
lead
to
mechanical
failure
or
illness
of
system
users.
Methods
for
evaluating
anti-fouling
coatings
have
largely
been
informed
by
the
medical
industry
not
tailored
industrial
spacecraft
systems.
The
goal
paper
is
help
guide
researchers
designing
experiments
evaluate
that
accurately
represent
under
investigation.
This
review
identified
eight
experimental
design
considerations
when
systems:
biofilm
reactor
operation,
microorganism
selection,
reinoculation,
coating
surface
area,
liquid
medium,
experiment
duration,
performance
evaluation,
use
microgravity.
impact
each
decision
made
within
these
presented.
Further,
methods
featured
studies
investigating
Earth-based
discussed.
serves
toward
improved
enable
successful
technology
transfer
from
lab
bench
Earth
beyond.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(9), P. 4348 - 4348
Published: May 3, 2025
Bone
tissue
engineering
(BTE)
emerged
as
a
practical
approach
to
tackle
prosthetic
industry
limitations.
We
merge
aspects
from
developmental
biology,
and
medicine
with
the
aim
produce
fully
functional
bone
tissue.
Mesenchymal
stem
cells
have
capability
of
self-renewal
specific
lineage
differentiation.
Herein
lies
their
potential
for
BTE.
Among
MSCs,
human
dental
pulp
higher
proliferation
rate,
shorter
doubling
times,
lower
cellular
senescence,
enhanced
osteogenesis
than
hBM-SCs
under
conditions.
In
addition,
these
are
readily
accessible
can
be
extracted
through
subtle
extraction
procedure.
Thus,
they
garner
fewer
moral
concerns
most
MSCs
available
embody
promising
cell
source
BTE
therapies
able
replace
hBM-MSCs.
Interestingly,
study
has
been
limited.
Conversely,
there
is
need
further
harness
true
value
in
BTE,
special
emphasis
design
bioprocesses
viable,
homogenous
constructs
clinical
scale.
Here,
we
osteogenic
differentiation
hDPSCs
encapsulated
alginate
hydrogels
suspended
culture
novel
perfusion
bioreactor.
The
system
compared
traditional
3D
static
fed-batch
methodologies.
performed
better,
producing
alkaline
phosphatase
activity,
more
homogeneous,
dense
constructs.
Additionally,
produced
by
in-house-designed
were
richer
mature
osteoblast-like
mineralizing
osteocyte-like
cells.
conclusion,
this
reports
development
bioprocess
hDPSC-based
bone-like
constructs,
providing
new
insights
into
hDPSCs’
therapeutic
transferred
laboratory
bench
medical
facilities.
PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(4), P. e0300701 - e0300701
Published: April 2, 2024
Space
medicine
is
a
vital
discipline
with
often
time-intensive
and
costly
projects
constrained
opportunities
for
studying
various
elements
such
as
space
missions,
astronauts,
simulated
environments.
Moreover,
private
interests
gain
increasing
influence
in
this
discipline.
In
scientific
disciplines
these
features,
transparent
rigorous
methods
are
essential.
Here,
we
undertook
an
evaluation
of
transparency
indicators
publications
within
the
field
medicine.
A
meta-epidemiological
assessment
PubMed
Central
Open
Access
(PMC
OA)
eligible
articles
was
performed
prevalence
code
sharing,
data
pre-registration,
conflicts
interest,
funding.
Text
mining
rtransparent
text
algorithms
manual
validation
200
random
to
obtain
corrected
estimates.
Across
1215
included
articles,
39
(3%)
shared
code,
258
(21%)
data,
10
(1%)
were
registered,
110
(90%)
contained
conflict-of-interest
statement,
1141
(93%)
funding
statement.
After
validation,
estimates
registration
5%,
27%,
1%,
respectively.
Data
sharing
32%
when
limited
original
highest
space/parabolic
flights
(46%).
Overall,
across
observed
modest
rates
rare
almost
non-existent
protocol
registration.
Enhancing
research
imperative
safeguarding
its
rigor
reproducibility.
