Polymer Journal,
Journal Year:
2024,
Volume and Issue:
56(7), P. 685 - 691
Published: March 5, 2024
Abstract
In
this
study,
we
utilized
tetra-armed
polyethylene
glycol
(Tetra-PEG)
slimes,
which
are
model
transient
networks
with
well-controlled
structures,
to
predict
the
effects
of
long-term
degradation
on
viscoelastic
properties
liquids.
Viscoelastic
liquids,
such
as
sodium
hyaluronate,
frequently
used
in
biomedical
applications
within
human
body.
However,
precisely
controlling
these
liquids
is
challenging,
main
chains
undergo
stochastic
degradation.
To
establish
a
predictable
for
studying
effects,
employed
Tetra-PEG
slime,
and
modifications
were
performed
introduce
specific
cleavage
sites
areas
connections.
The
slimes
characterized
by
single
relaxation
modes,
modes
independent
from
degree
degradation,
was
determined
hydrolyzing
sites.
Overall,
work
provides
universal
design
precisely-controllable
Expert Opinion on Drug Delivery,
Journal Year:
2024,
Volume and Issue:
21(7), P. 1115 - 1141
Published: July 2, 2024
Introduction
Wound
healing
is
an
intricate
and
continual
process
influenced
by
numerous
factors
that
necessitate
suitable
environments
to
attain
healing.
The
natural
ability
of
wound
often
gets
altered
several
external
intrinsic
factors,
leading
chronic
occurrence.
Numerous
dressings
have
been
developed,
however,
the
currently
available
alternatives
fail
coalesce
all
conditions
obligatory
for
rapid
skin
regeneration.
Drug Delivery and Translational Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 22, 2024
Abstract
Tissue
engineering
combines
biology
and
to
develop
constructs
for
repairing
or
replacing
damaged
tissues.
Over
the
last
few
years,
this
field
has
seen
significant
advancements,
particularly
in
bone
tissue
engineering.
3D
printing
revolutionised
field,
allowing
fabrication
of
patient-
defect-specific
scaffolds
enhance
regeneration,
thus
providing
a
personalised
approach
that
offers
unique
control
over
shape,
size,
structure
3D-printed
constructs.
Accordingly,
thermoplastic
polyurethane
(TPU)-based
loaded
with
dipyridamole
(DIP)
were
manufactured
evaluate
their
vitro
osteogenic
capacity.
The
fabricated
DIP-loaded
TPU-based
fully
characterised,
physical
mechanical
properties
analysed.
Moreover,
DIP
release
profile,
biocompatibility
murine
calvaria-derived
pre-osteoblastic
cells,
intracellular
alkaline
phosphatase
(ALP)
assay
verify
ability
evaluated.
results
suggested
these
materials
offered
an
attractive
option
preparing
due
properties.
Indeed,
addition
concentrations
up
10%
did
not
influence
compression
modulus.
containing
highest
cargo
(10%
w/w)
able
provide
sustained
drug
30
days.
Furthermore,
cell
viability,
proliferation,
osteogenesis
MC3T3-E1
cells
significantly
increased
compared
samples.
These
promising
suggest
may
regeneration.
Combined
flexibility
printing,
potential
enable
creation
customized
tailored
patients’
needs
at
point
care
future.
Graphical
Cureus,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 8, 2024
The
field
of
wound
healing
faces
significant
challenges,
particularly
in
the
treatment
chronic
wounds,
which
often
result
prolonged
times
and
complications.
Recent
advancements
3D
printing
technology
have
provided
innovative
solutions
to
these
offering
tailored
precise
approaches
care.
This
review
highlights
role
enhancing
healing,
focusing
on
its
application
creating
biocompatible
scaffolds,
custom
dressings,
drug
delivery
systems.
By
mimicking
extracellular
matrix
(ECM)
facilitating
cell
proliferation,
3D-printed
biomaterials
potential
significantly
accelerate
process.
In
addition,
bioprinting
enables
production
functional
skin
substitutes
that
can
be
customized
for
individual
patients.
Despite
promise
technologies,
several
challenges
remain,
including
need
improved
vascularization,
cost
concerns,
regulatory
hurdles.
future
lies
continued
integration
with
emerging
technologies
such
as
4D
bioelectronics,
providing
opportunities
personalized
on-demand
therapies.
explores
current
state
care,
technologies.
Polymer Journal,
Journal Year:
2024,
Volume and Issue:
56(7), P. 685 - 691
Published: March 5, 2024
Abstract
In
this
study,
we
utilized
tetra-armed
polyethylene
glycol
(Tetra-PEG)
slimes,
which
are
model
transient
networks
with
well-controlled
structures,
to
predict
the
effects
of
long-term
degradation
on
viscoelastic
properties
liquids.
Viscoelastic
liquids,
such
as
sodium
hyaluronate,
frequently
used
in
biomedical
applications
within
human
body.
However,
precisely
controlling
these
liquids
is
challenging,
main
chains
undergo
stochastic
degradation.
To
establish
a
predictable
for
studying
effects,
employed
Tetra-PEG
slime,
and
modifications
were
performed
introduce
specific
cleavage
sites
areas
connections.
The
slimes
characterized
by
single
relaxation
modes,
modes
independent
from
degree
degradation,
was
determined
hydrolyzing
sites.
Overall,
work
provides
universal
design
precisely-controllable
