Advantages and disadvantages of targeting senescent endothelial cells in cardiovascular and cerebrovascular diseases based on small extracellular vesicles DOI
Wen Ma,

Tingyuan Zhou,

Songling Tang

et al.

Expert Opinion on Therapeutic Targets, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 15

Published: Oct. 30, 2024

With the growth of aging population, age-related diseases have become a heavy global burden, particularly cardiovascular and cerebrovascular (CVDs). Endothelial cell (EC) senescence constitutes an essential factor in development CVDs, prompting increased focus on strategies to alleviate or reverse EC senescence.

Language: Английский

Stem-Cell Derived Exosomal microRNAs as Biomarkers and Therapeutics for Pediatric Cardiovascular Disease DOI Creative Commons
Aaron H. Wasserman,

Bana Abolibdeh,

Reema Hamdan

et al.

Current Treatment Options in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 27(1)

Published: April 9, 2025

In recent years, several pre-clinical studies have demonstrated the therapeutic potential of stem cell-derived exosomes in treatment cardiovascular disease (CVD). Here, we evaluate their as biomarkers for detection and monitoring CVD, with a particular focus on pediatric heart disease. Exosomes isolated from cell sources, including mesenchymal cells (MSCs) pluripotent (PSCs), benefit function, inflammatory responses, angiogenesis injured diseased hearts. These carry variety cargo, such proteins, lipids, nucleic acids. However, majority contain non-coding RNA molecules. Review existing literature RNAs relationship to CVD suggests that containing microRNAs (miRNAs) can serve promising due presence circulation, ease isolation, potential. are especially screening diagnostic tools early congenital

Language: Английский

Citations

0
LncRNA ZFAS1/miR-186-5p axis is involved in oxidative stress inhibition of myocardial ischemia-reperfusion injury by targeting BTG2 DOI

Yi Xiang,

Hui Shan, Hao Nie

et al.

Expert Review of Clinical Immunology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 12

Published: Oct. 4, 2024

To probe the involvement of long noncoding RNA zinc finger antisense 1 (ZFAS1)/microRNA (miR)-186-5p axis in inhibiting oxidative stress myocardial ischemia-reperfusion injury (MIRI) by targeting B-cell translocation gene 2 (BTG2).

Language: Английский

Citations

1
Advantages and disadvantages of targeting senescent endothelial cells in cardiovascular and cerebrovascular diseases based on small extracellular vesicles DOI
Wen Ma,

Tingyuan Zhou,

Songling Tang

et al.

Expert Opinion on Therapeutic Targets, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 15

Published: Oct. 30, 2024

With the growth of aging population, age-related diseases have become a heavy global burden, particularly cardiovascular and cerebrovascular (CVDs). Endothelial cell (EC) senescence constitutes an essential factor in development CVDs, prompting increased focus on strategies to alleviate or reverse EC senescence.

Language: Английский

Citations

1