Proposing Novel Biological Scaffolds for the Regeneration of the Dura Mater DOI

Mohammad Mehdi Monazah,

Ehsan Alimohammadi, Gelavizh Rostaminasab

et al.

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(11)

Published: Nov. 1, 2024

ABSTRACT The dura mater protects underlying tissues and cerebrospinal fluid, but dural abnormalities can cause leaking meningitis wound infections. This review emphasizes the relevance of repair progress reconstruction materials, focusing on biological scaffolds. A comprehensive assessment substitution literature focused composite, acellular, natural, synthetic, homologous materials. Decellularized scaffolds as viable natural biomaterials for tissue engineering are explored in this overview these materials' properties, effectiveness, therapeutic uses. evaluation also compares materials assesses host response preclinical clinical studies. highlights various findings. There is no gold standard repair, despite variety used. Replicating mater's mechanical structural qualities difficult. Recent research suggests that decellularized regenerate while reducing inflammation transplant rejection. Furthermore, movement toward personalized medicine sector bespoke alternatives might be chosen depending patient characteristics, improving treatment effects. Synthesizing replacement uses adds to knowledge. It tackles shortcomings shows how improve repair. analysis opens door enhance outcomes advance neurosurgery. insights presented herein highlight intriguing prospects appropriate restorative seeking defect treatment.

Language: Английский

Recent applications of stimulus-responsive smart hydrogels for osteoarthritis therapy DOI Creative Commons
Zhuoming Xu, Jintao Liu,

Hanyin Hu

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 17, 2025

Osteoarthritis is one of the most common degenerative joint diseases, which seriously affects life middle-aged and elderly people. Traditional treatments such as surgical treatment systemic medication, often do not achieve expected or optimal results, leads to severe trauma a variety side effects. Therefore, there an urgent need develop novel therapeutic options overcome these problems. Hydrogels are widely used in biomedical tissue repairing platform for loading drugs, proteins stem cells. In recent years, smart-responsive hydrogels have achieved excellent results drug delivery systems osteoarthritis. This review focuses on advances endogenous stimuli (including enzymes, pH, reactive oxygen species temperature, etc.) responsive exogenous light, shear, ultrasound magnetism, osteoarthritis treatment. Finally, current limitations application future prospects smart summarized.

Language: Английский

Citations

0
Applications of Hydrogels in Emergency Therapy DOI Creative Commons
Mariana Chelu, Mónica Popa,

José María Calderón Moreno

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 234 - 234

Published: March 23, 2025

Interest in developing new, effective materials for emergency hemostasis and wound healing is steadily increasing, particularly use emergency, surgical, military situations. Hydrogels, with their unique retention, swelling, biocompatibility properties, have emerged as essential therapy. This review provides a comprehensive examination of recent hydrogel applications acute medical scenarios, including hemostasis, management, drug delivery, soft tissue replacement, engineering. We discuss the physicochemical properties that make hydrogels suitable rapid response situations, such tunable mechanical strength, adhesiveness, responsiveness to environmental stimuli, ability encapsulate release therapeutic agents. Additionally, article explores advancements smart self-healing antimicrobial providing insights into potential revolutionize care increase survival rates both civilian applications. Through critical evaluation current clinical trials practical deployments, this highlights successes challenges faced integrating protocols, roadmap future research development dynamic field.

Language: Английский

Citations

0
Polymeric Hydrogels for Bioprinting: A Comprehensive Review DOI Creative Commons
Mohammad Amir Qureshi,

Basree,

R. Aziz

et al.

Annals of 3D Printed Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100198 - 100198

Published: March 1, 2025

Language: Английский

Citations

0
Optimised GelMA/tragacanth gum hydrogel loaded with vanillic acid for biomedical applications DOI

Atefeh Golshirazi,

Sheyda Labbaf,

Jaleh Varshosaz

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143535 - 143535

Published: April 1, 2025

Language: Английский

Citations

0
Advancement on heparin-based hydrogel/scaffolds in biomedical and tissue engineering applications: Delivery carrier and pre-clinical implications DOI
Shubhrajit Mantry, Prabhat Kumar Das,

Jonna Sankaraiah

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125733 - 125733

Published: May 1, 2025

Language: Английский

Citations

0
Next-Generation Hydrogel Design: Computational Advances in Synthesis, Characterization, and Biomedical Applications DOI Open Access
Muhammad Mazhar Fareed, Sergey Shityakov

Polymers, Journal Year: 2025, Volume and Issue: 17(10), P. 1373 - 1373

Published: May 16, 2025

Hydrogels are pivotal in advanced materials, driving innovations medical fields, such as targeted drug delivery, regenerative medicine, and skin repair. This systematic review explores the transformative impact of in-silico design on hydrogel development, leveraging computational tools molecular dynamics, finite element modeling, artificial intelligence to optimize synthesis, characterization, performance. We analyze cutting-edge strategies for tailoring physicochemical properties hydrogels, including their mechanical strength, biocompatibility, stimulus responsiveness, meet needs next-generation biomedical applications. By integrating machine learning modeling with experimental validation, this highlights how silico approaches accelerate material innovation, addressing challenges outlining future directions scalable, personalized solutions medicine beyond.

Language: Английский

Citations

0
The role of biophysical cues and their modulated exosomes in dental diseases: from mechanism to therapy DOI Creative Commons

Bilun Jin,

Yuxin Liao,

Zhenya Ding

et al.

Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)

Published: Oct. 19, 2024

Language: Английский

Citations

1
Proposing Novel Biological Scaffolds for the Regeneration of the Dura Mater DOI

Mohammad Mehdi Monazah,

Ehsan Alimohammadi, Gelavizh Rostaminasab

et al.

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(11)

Published: Nov. 1, 2024

ABSTRACT The dura mater protects underlying tissues and cerebrospinal fluid, but dural abnormalities can cause leaking meningitis wound infections. This review emphasizes the relevance of repair progress reconstruction materials, focusing on biological scaffolds. A comprehensive assessment substitution literature focused composite, acellular, natural, synthetic, homologous materials. Decellularized scaffolds as viable natural biomaterials for tissue engineering are explored in this overview these materials' properties, effectiveness, therapeutic uses. evaluation also compares materials assesses host response preclinical clinical studies. highlights various findings. There is no gold standard repair, despite variety used. Replicating mater's mechanical structural qualities difficult. Recent research suggests that decellularized regenerate while reducing inflammation transplant rejection. Furthermore, movement toward personalized medicine sector bespoke alternatives might be chosen depending patient characteristics, improving treatment effects. Synthesizing replacement uses adds to knowledge. It tackles shortcomings shows how improve repair. analysis opens door enhance outcomes advance neurosurgery. insights presented herein highlight intriguing prospects appropriate restorative seeking defect treatment.

Language: Английский

Citations

0