A Comprehensive Numerical Study on the Transport and Deposition of Nasal Sprayed Pharmaceutical Aerosols in a Nasal‐To‐Lung Respiratory Tract Model DOI Creative Commons
Xinlei Huang, Yao hui Yin, Goutam Saha

et al.

Particle & Particle Systems Characterization, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 23, 2024

Abstract Utilizing a computed tomography (CT)‐based realistic nasal‐to‐lung respiratory tract model allows for comprehensive investigation of the transport and deposition nasal sprayed aerosols. This study has three main objectives: first, to determine optimal mesh that achieves quickest convergence computational fluid‐particle dynamics (CFPD) simulations by assessing performance different element types, sizes, prism boundary layers; second, design validate numerical method compare grid data with structures densities simulation result validation; finally, observe analyze in aid development medications. involves reverse‐engineering anatomically accurate from CT scans. Results reveal approach minimum calculation time is polyhedral hybrid four layers SIMPLE pressure‐velocity coupling scheme. Furthermore, observations particle vocal cords' location contains concentration site deposited small aerosols due turbulent airflow region. The diameters target each region are concluded end.

Language: Английский

A Computational Fluid Dynamics Analysis of BiPAP Pressure Settings on Airway Biomechanics Using a CT-Based Respiratory Tract Model DOI Creative Commons
Xinlei Huang, Goutam Saha, Akshoy Ranjan Paul

et al.

Respiratory Physiology & Neurobiology, Journal Year: 2025, Volume and Issue: unknown, P. 104397 - 104397

Published: Jan. 1, 2025

Language: Английский

Citations

0
A Comprehensive Numerical Study on the Transport and Deposition of Nasal Sprayed Pharmaceutical Aerosols in a Nasal‐To‐Lung Respiratory Tract Model DOI Creative Commons
Xinlei Huang, Yao hui Yin, Goutam Saha

et al.

Particle & Particle Systems Characterization, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 23, 2024

Abstract Utilizing a computed tomography (CT)‐based realistic nasal‐to‐lung respiratory tract model allows for comprehensive investigation of the transport and deposition nasal sprayed aerosols. This study has three main objectives: first, to determine optimal mesh that achieves quickest convergence computational fluid‐particle dynamics (CFPD) simulations by assessing performance different element types, sizes, prism boundary layers; second, design validate numerical method compare grid data with structures densities simulation result validation; finally, observe analyze in aid development medications. involves reverse‐engineering anatomically accurate from CT scans. Results reveal approach minimum calculation time is polyhedral hybrid four layers SIMPLE pressure‐velocity coupling scheme. Furthermore, observations particle vocal cords' location contains concentration site deposited small aerosols due turbulent airflow region. The diameters target each region are concluded end.

Language: Английский

Citations

0