Computers in Biology and Medicine, Journal Year: 2025, Volume and Issue: 191, P. 110166 - 110166

Published: April 17, 2025

Early detection of brain tumors in MRI images is vital for improving treatment results. However, deep learning models face challenges like limited dataset diversity, class imbalance, and insufficient interpretability. Most studies rely on small, single-source datasets do not combine different feature extraction techniques better classification. To address these challenges, we propose a robust explainable stacking ensemble model multiclass tumor that combines EfficientNetB0, MobileNetV2, GoogleNet, Multi-level CapsuleNet, using CatBoost as the meta-learner improved aggregation classification accuracy. This approach captures complex characteristics while enhancing robustness The proposed integrates CapsuleNet within framework, utilizing to improve We created two large by merging data from four sources: BraTS, Msoud, Br35H, SARTAJ. tackle applied Borderline-SMOTE augmentation. also utilized methods, along with PCA Gray Wolf Optimization (GWO). Our was validated through confidence interval analysis statistical tests, demonstrating superior performance. Error revealed misclassification trends, assessed computational efficiency regarding inference speed resource usage. achieved 97.81% F1 score 98.75% PR AUC M1, 98.32% 99.34% M2. Moreover, consistently surpassed state-of-the-art CNNs, Vision Transformers, other methods classifying across individual datasets. Finally, developed web-based diagnostic tool enables clinicians interact visualize decision-critical regions scans Explainable Artificial Intelligence (XAI). study connects high-performing AI real clinical applications, providing reliable, scalable, efficient solution

Language: Английский