Development, Characterization, and Biomedical Applications of PVP–AgCl Nanomaterials: Antibacterial and Anticancer Properties DOI Open Access
Kokkarachedu Varaprasad, Tippabattini Jayaramudu,

Chandrasekaran Kartikeyan

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 10(1)

Published: Dec. 30, 2024

Abstract The demand for smaller nanomaterials with biocompatible properties has become increasingly imperative in the quest to combat microbial infections and cancer. This requires modifying chemical process. In this investigation, polyvinylpyrrolidone–silver chloride (PVP–AgCl) (NMs) were developed via a sonochemical method involving Ag + sourced from AgNO 3 metal precursor Cl − NaCl, assistance of capping agent PVP. Synthesized NMs characterized using XRD, FTIR, SEM/EDS, DLS TEM. SEM analysis indicated spindle‐like structures star‐shaped formations at edges, whereas TEM showed size ∼24 ± nm. Furthermore, PVP–AgCl exhibited zeta potential approximately −18.34 mV, an average hydrodynamic diameter 127.7 1.287 nm polydispersity index 0.1879. anticancer activity tested against cervical cancer cells (HeLa). addition, toxicity studies fibroblast cell (L929) revealed that demonstrate significant while showing minimal toward L929 cells. antimicrobial was S. aureus E. coli strains. prepared exhibit properties. These findings suggest are used biomedicine coatings applications.

Language: Английский

Ashwagandha: Optimizing the Extraction and Electrospun Nanofiber Production DOI Creative Commons

Maciej Jaskólski,

Magdalena Paczkowska-Walendowska, Andrzej Miklaszewski

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 61 - 61

Published: Jan. 5, 2025

Background/Objectives: This study explores the development of electrospun nanofibers incorporating bioactive compounds from Withania somnifera (Ashwagandha) root extract, focusing on optimizing extraction conditions and nanofiber composition to maximize biological activity application potential. Methods: Using Design Experiment (DoE) approach, optimal parameters were identified as 80% methanol, 70 °C, 60 min, yielding high levels phenolic antioxidant activity. Methanol concentration emerged critical factor influencing phytochemical properties. Electrospinning technology was employed produce using polyvinylpyrrolidone (PVP) hydroxypropyl-β-cyclodextrin (HPβCD) carriers, ensuring encapsulation, stabilization, an enhanced bioavailability active compounds. Results: Nanofibers demonstrated a surface-to-volume ratio, rapid dissolution, significant mucoadhesive properties, making them suitable for oral mucosal applications. The determined be 2.5 mL 25% PVP, extract-to-HPβCD ratio 1:0.6. Statistical modeling confirmed that electrospinning process did not compromise or anti-inflammatory properties with extract content being primary determinant Conclusions: These findings highlight potential integrating advanced techniques nanotechnology develop innovative delivery systems traditional herbal remedies. developed offer promising applications in pharmaceuticals, cosmetics, functional foods, paving way scalable efficient utilization Ashwagandha bioactives.

Language: Английский

Citations

0
Thermodynamics, reaction Dynamics, and Temperature-Dependent Mechanistic insights into Surfactant-Free and Surfactant-Mediated formation of selenium nanoparticles in aqueous media DOI

Y. Khalifa,

Lobna A. E. Nassr, Ali M. Shaker

et al.

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 127428 - 127428

Published: March 1, 2025

Language: Английский

Citations

0
Development, Characterization, and Biomedical Applications of PVP–AgCl Nanomaterials: Antibacterial and Anticancer Properties DOI Open Access
Kokkarachedu Varaprasad, Tippabattini Jayaramudu,

Chandrasekaran Kartikeyan

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 10(1)

Published: Dec. 30, 2024

Abstract The demand for smaller nanomaterials with biocompatible properties has become increasingly imperative in the quest to combat microbial infections and cancer. This requires modifying chemical process. In this investigation, polyvinylpyrrolidone–silver chloride (PVP–AgCl) (NMs) were developed via a sonochemical method involving Ag + sourced from AgNO 3 metal precursor Cl − NaCl, assistance of capping agent PVP. Synthesized NMs characterized using XRD, FTIR, SEM/EDS, DLS TEM. SEM analysis indicated spindle‐like structures star‐shaped formations at edges, whereas TEM showed size ∼24 ± nm. Furthermore, PVP–AgCl exhibited zeta potential approximately −18.34 mV, an average hydrodynamic diameter 127.7 1.287 nm polydispersity index 0.1879. anticancer activity tested against cervical cancer cells (HeLa). addition, toxicity studies fibroblast cell (L929) revealed that demonstrate significant while showing minimal toward L929 cells. antimicrobial was S. aureus E. coli strains. prepared exhibit properties. These findings suggest are used biomedicine coatings applications.

Language: Английский

Citations

0