Causal relationships between allergic and autoimmune diseases with chronic rhinosinusitis DOI Creative Commons
Junhao Tu, Zhiqiang Zhang, Fan Jiang

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 25, 2024

Chronic rhinosinusitis (CRS) is a prevalent inflammatory airway disease affecting over 10% of the global population, leading to considerable socio-economic impacts, especially in developing countries. The pathogenesis CRS multifactorial, involving potential contributions from both genetic and environmental factors. While influence allergic autoimmune diseases on has been observed, causal relationships between these remain unclear. We extracted data large-scale genome-wide association studies (GWAS) utilized bidirectional two-sample Mendelian randomization (MR) analysis explore ten diseases, including asthma, rhinitis (AR), atopic dermatitis (AD), psoriasis, type 1 diabetes (T1D), hypothyroidism, celiac (CeD), multiple sclerosis (MS), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE). Additionally, we conducted colocalization determine whether allergic/autoimmune showing statistical with are driven by same variants. MR identified that AR (OR = 1.30; 95% CI 1.21-1.40; P 3.26E-13), asthma 1.35; 1.25-1.45; 1.35E-14), AD 1.17; 1.06-1.30; 0.003) were significantly associated an increased risk CRS. Interestingly, psoriasis 0.05; 0.01-0.37; 0.004) appeared have protective effect against Associations for T1D hypothyroidism also suggestive as factors No significant associations reverse analysis, suggesting one-directional relationship. Colocalization indicated (PP.H4 0.99) shared variant (IL-33 rs3939286) In conclusion, our study confirmed (AR, AD, psoriasis) Notably, variant, rs3939286 IL-33 gene, CRS, targeting pathway may provide therapeutic strategy diseases.

Language: Английский

Interleukin 8 Molecular Interplay in Allergic Rhinitis and Chronic Rhinosinusitis with Nasal Polyps: A Scoping Review DOI Creative Commons

Romică Cergan,

Ovidiu Berghi, Mihai Dumitru

et al.

Life, Journal Year: 2025, Volume and Issue: 15(3), P. 469 - 469

Published: March 15, 2025

The present scoping review underlines the molecular interplay between allergic rhinitis (AR), chronic rhinosinusitis with nasal polyps (CRSwNP), and interleukin-8 (IL-8). A query of PubMed database resulted in inclusion 34 articles final analysis this review. IL-8 is one interconnecting immune mediator physiopathology AR CRS. An influx cytokines, such as interleukin (IL)-4 IL-13, occurs from mast cells, four to six hours after initial response signifying development late-phase allowing entrance eosinophils, basophils, T-lymphocytes at level mucosa. Chronic (CRS) a inflammatory disease that mucosa cavity sinuses two external phenotypes, but mechanisms overlap rhinitis. Interleukin 8 induces neutrophil chemokinetic movement providing chemotactic or directional cue. Clinical fundamental studies established an implication mechanism CRSwNP. Moreover, there still missing randomized, large-cohort study three patients groups (normal control, AR, CRSwNP) analyzes impact simultaneously. Future possible developments could focus on target for biologic treatments.

Language: Английский

Citations

0
Causal relationships between allergic and autoimmune diseases with chronic rhinosinusitis DOI Creative Commons
Junhao Tu, Zhiqiang Zhang, Fan Jiang

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 25, 2024

Chronic rhinosinusitis (CRS) is a prevalent inflammatory airway disease affecting over 10% of the global population, leading to considerable socio-economic impacts, especially in developing countries. The pathogenesis CRS multifactorial, involving potential contributions from both genetic and environmental factors. While influence allergic autoimmune diseases on has been observed, causal relationships between these remain unclear. We extracted data large-scale genome-wide association studies (GWAS) utilized bidirectional two-sample Mendelian randomization (MR) analysis explore ten diseases, including asthma, rhinitis (AR), atopic dermatitis (AD), psoriasis, type 1 diabetes (T1D), hypothyroidism, celiac (CeD), multiple sclerosis (MS), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE). Additionally, we conducted colocalization determine whether allergic/autoimmune showing statistical with are driven by same variants. MR identified that AR (OR = 1.30; 95% CI 1.21-1.40; P 3.26E-13), asthma 1.35; 1.25-1.45; 1.35E-14), AD 1.17; 1.06-1.30; 0.003) were significantly associated an increased risk CRS. Interestingly, psoriasis 0.05; 0.01-0.37; 0.004) appeared have protective effect against Associations for T1D hypothyroidism also suggestive as factors No significant associations reverse analysis, suggesting one-directional relationship. Colocalization indicated (PP.H4 0.99) shared variant (IL-33 rs3939286) In conclusion, our study confirmed (AR, AD, psoriasis) Notably, variant, rs3939286 IL-33 gene, CRS, targeting pathway may provide therapeutic strategy diseases.

Language: Английский

Citations

2