Nanotechnology for Targeted Inflammatory Bowel Disease Therapy: Challenges and Opportunities DOI
Meng‐Tzu Weng,

Chao A. Hsiung,

Shu‐Chen Wei

et al.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(5)

Published: Sept. 1, 2024

ABSTRACT Inflammatory bowel disease (IBD) is a complex and recurring inflammatory disorder that affects the gastrointestinal tract influenced by genetic predisposition, immune dysregulation, gut microbiota, environmental factors. Advanced therapies, such as biologics small molecules, target diverse pathways to manage IBD. Nanoparticle (NP)‐based drugs have emerged effective tools, offering controlled drug release targeted delivery. This review highlights NP modifications for anti‐inflammatory purposes, utilizing changes those in size, charge, redox reactions, ligand–receptor interactions delivery systems. By using pathological microenvironmental cues guide design, precise targeting can be achieved. In IBD, crucial aspect of intervention specific types cells, epithelial address compromised intestinal barrier function reduce overactive responses. also addresses current challenges future prospects, with goal advancing development NP‐mediated strategies IBD treatment.

Language: Английский

Beyond borders: A systematic review and meta-analysis of human-specific faecal markers across geographical settings DOI Creative Commons
Leah R. Barrett,

Paris Beasy,

Yussi M. Palacios Delgado

et al.

Critical Reviews in Environmental Science and Technology, Journal Year: 2025, Volume and Issue: 55(7), P. 447 - 464

Published: Feb. 6, 2025

Human fecal waste is a global health risk associated with diarrheal diseases, responsible for approximately 1.2 million deaths annually. Microbial Source Tracking (MST) molecular method that evaluates environmental sources of contamination, aiding quantification this contamination and risks. However, reported variations in human gut microbiomes geographic performance human-specific markers suggest current MST targets may not have broad applicability across populations. This systematic review quantified the to identify those suitable use various regions. We evaluated data from primary research articles, published before 18th October 2023, identified through PubMed, Scopus, Web Science using PRISMA guidelines. 103 studies between 1995 spanning 34 countries, 6 continents, 4 climate zones met inclusion criteria, quantifiable metrics (sensitivity, specificity or accuracy) testing location. Extracted was analyzed establish marker locations, zones, development status. Over 80% were conducted High-Income Countries (HICs) >50% temperate primarily USA (43%), Australia (24%), Spain (19%). Bacteroides HF183 most commonly tested (n = 45 studies). no target consistently demonstrated sensitivity, specificity, and/or accuracy >80% different settings. Consequently, decision tree presented supporting selection appropriate regional-specific baseline studies. provides critical information support new research, particularly Low- Middle-Income (LMICs), assisting informed assessing risks faecal derived pathogens.

Language: Английский

Citations

0
Investigation of Factors Associated with Gut Microbiota in Demodex-associated Skin Conditions DOI Creative Commons
Fatmagül Gülbaşaran,

Seray Sarımustafa,

Özlem Özbağçıvan

et al.

Turkish Journal of Parasitology, Journal Year: 2024, Volume and Issue: unknown, P. 171 - 177

Published: Oct. 7, 2024

This study describes the relationships of factors related to gut microbiota and skin conditions associated with

Language: Английский

Citations

0
Nanotechnology for Targeted Inflammatory Bowel Disease Therapy: Challenges and Opportunities DOI
Meng‐Tzu Weng,

Chao A. Hsiung,

Shu‐Chen Wei

et al.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(5)

Published: Sept. 1, 2024

ABSTRACT Inflammatory bowel disease (IBD) is a complex and recurring inflammatory disorder that affects the gastrointestinal tract influenced by genetic predisposition, immune dysregulation, gut microbiota, environmental factors. Advanced therapies, such as biologics small molecules, target diverse pathways to manage IBD. Nanoparticle (NP)‐based drugs have emerged effective tools, offering controlled drug release targeted delivery. This review highlights NP modifications for anti‐inflammatory purposes, utilizing changes those in size, charge, redox reactions, ligand–receptor interactions delivery systems. By using pathological microenvironmental cues guide design, precise targeting can be achieved. In IBD, crucial aspect of intervention specific types cells, epithelial address compromised intestinal barrier function reduce overactive responses. also addresses current challenges future prospects, with goal advancing development NP‐mediated strategies IBD treatment.

Language: Английский

Citations

0