Understanding the synergistic interaction between a 1,3,4-thiadiazole derivative and amphotericin B using spectroscopic and theoretical studies DOI Creative Commons
Lidia Ślusarczyk, Klaudia Rząd, Grzegorz Niedzielski

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 30, 2024

We present a comprehensive spectroscopic study supported by theoretical quantum chemical calculations conducted on molecular system (4-(5-methyl-1,3,4-thiadiazol-2-yl)benzene-1,3-diol (C1) and the antibiotic Amphotericin B (AmB)) that exhibits highly synergistic properties. previously reported strong synergism of this now wish to related stationary measurements UV-Vis absorption, fluorescence, fluorescence anisotropy in polar, aprotic solvent (DMSO PBS buffer), followed time-resolved intensity decay studies using different ratios selected 1,3,4-thiadiazole derivative B. Absorption spectra measured for revealed discrepancies terms shapes absorption bands, particularly PBS. Fluorescence emission addition C1 molecules triggered significant changes system. Measurements lifetimes synchronous clearly showed evidence disaggregation. The AmB aggregates indicated interaction with at points responsible formation dimer structures. results were further corroborated, analyzed, interpreted methods mechanical modelling. Analyses based density functional tight-binding time-dependent theory confirmed interactions between "small" lead increase clinical efficacy antibiotic.

Language: Английский

AIEE-driven highly sensitive fluorescent probe for Fe3+ sensing in aqueous and solid phases: application in interference-free biological media DOI Creative Commons

Rida Khalid,

Tayyeba Javid,

Aqsa Pervaiz

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(11), P. 8456 - 8463

Published: Jan. 1, 2025

Herein, a novel fluorescein-based fluorescent probe FHP was systematically designed and synthesised, which exhibited aggregation-induced emission enhancement (AIEE) properties.

Language: Английский

Citations

0
From Donor–Donor Exciplex-Forming Interfaces to Detection of an Explosive Compound with Phenylethenyl Derivatives Redefining OLED Efficiency and Extremely High Sensitivity to Picric Acid DOI Creative Commons

Ehsan Ullah Rashid,

Monika Cekaviciute,

Jurate Simokaitiene

et al.

ACS Applied Electronic Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Language: Английский

Citations

0
A Novel Electrochemical Sensing Platform for Detection of Nitrobenzene Using Gadolinium Oxide Nanorods Modified Gold Electrode DOI
Bharti Sharma, Shikha Jain, Neeraj Dilbaghi

et al.

Indian Journal of Microbiology, Journal Year: 2024, Volume and Issue: 65(1), P. 505 - 514

Published: Sept. 17, 2024

Language: Английский

Citations

1
Fabrication of Anthocyanidin-Encapsulated Polyvinyl Alcohol Nanofibrous Membrane for Smart Packaging DOI Creative Commons

Maryam Aldoghaim,

Jabrah Alkorbi,

Salhah D. Al‐Qahtani

et al.

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(21), P. 1701 - 1701

Published: Oct. 24, 2024

Smart colorimetric packaging has been an important method to protect human health from external hazardous agents. However, the currently available detectors use synthetic dye probes, which are costly, toxic, difficult prepare, and non-biodegradable. Herein, environmentally friendly cellulose nanocrystal (CNC)-supported polyvinyl alcohol (PVA) nanofibrous membrane was developed for monitoring of food spoilage. Anthocyanidin (ACY) is a naturally occurring spectroscopic probe that isolated pomegranate (

Language: Английский

Citations

0
Drug molecules beyond chemical biology: fluorescence- and DFT-based investigations for fluoride ion sensing and the trace detection of chloroform DOI Creative Commons
Sohail Anjum Shahzad,

Tayyeba Javid,

Mohammed A. Assiri

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(51), P. 37993 - 38001

Published: Jan. 1, 2024

Excessive unmonitored use of fluoride has remained a threatening issue for long time now as its long-term is linked to several health issues.

Language: Английский

Citations

0
Insight into the ferrate(VI)/ozone process: Multiple oxidation systems promote the elimination of electron-deficient pollutants DOI
Xin Dai,

Du Ye,

Jie-Yu Cao

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 158211 - 158211

Published: Dec. 1, 2024

Language: Английский

Citations

0
Understanding the synergistic interaction between a 1,3,4-thiadiazole derivative and amphotericin B using spectroscopic and theoretical studies DOI Creative Commons
Lidia Ślusarczyk, Klaudia Rząd, Grzegorz Niedzielski

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 30, 2024

We present a comprehensive spectroscopic study supported by theoretical quantum chemical calculations conducted on molecular system (4-(5-methyl-1,3,4-thiadiazol-2-yl)benzene-1,3-diol (C1) and the antibiotic Amphotericin B (AmB)) that exhibits highly synergistic properties. previously reported strong synergism of this now wish to related stationary measurements UV-Vis absorption, fluorescence, fluorescence anisotropy in polar, aprotic solvent (DMSO PBS buffer), followed time-resolved intensity decay studies using different ratios selected 1,3,4-thiadiazole derivative B. Absorption spectra measured for revealed discrepancies terms shapes absorption bands, particularly PBS. Fluorescence emission addition C1 molecules triggered significant changes system. Measurements lifetimes synchronous clearly showed evidence disaggregation. The AmB aggregates indicated interaction with at points responsible formation dimer structures. results were further corroborated, analyzed, interpreted methods mechanical modelling. Analyses based density functional tight-binding time-dependent theory confirmed interactions between "small" lead increase clinical efficacy antibiotic.

Language: Английский

Citations

0