Ashwagandharishta compounds possess affinity interactions against diabetes-linked liver cancer: Implications from network pharmacology, molecular docking and dynamics simulations DOI

Annadurai Vinothkanna,

Ligang Chen,

Ragothaman Prathiviraj

et al.

South African Journal of Botany, Journal Year: 2024, Volume and Issue: 177, P. 26 - 49

Published: Dec. 2, 2024

Language: Английский

Ameliorative Effect of Rauwolfia vomitoria Ethanol Extract on the Erectile Dysfunction Complicated with Coronary Artery Disease: An In-Vivo and Molecular Docking Approach DOI

Hamdalat Folake Muritala,

Ramzi Abdulrahman, Habeebat Adekilekun Oyewusi

et al.

Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Language: Английский

Citations

0
An in- vitro measurement for the toxicity of peptides inhibit hexokinase II in breast cancer cell lines DOI Creative Commons
Faranak Karamifard, Ali Dadbinpour, Mahta Mazaheri

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 27, 2025

The role of the enzyme hexokinase 2 in many cancers has been identified through increased glycolysis or binding to pro-apoptotic channel located outer mitochondrial membrane, (VDCA1) and protein kinase (MTOR). To prevent cancer-causing pathways this enzyme, it is possible disrupt interaction subunits. Peptides can be utilized interfere with subunits by amino acids that contribute dimerization. Nowadays, peptides have become a suitable option for treatment various diseases, especially cancer, due their small size, ease synthesis, ability penetrate tumor. This study examined toxic effect inhibit on tumorigenic MCF-7 MDA-MB-231 non-tumorigenic MCF10A cell lines MTT analysis flow cytometry determine apoptosis. line experienced significant decrease proliferation both peptides. RYALFSS peptide caused number cells, but EKGLGATTHPTAAVKML increase. There was no increase line. study's finding indicate serve as tool carcinogenic cells.

Language: Английский

Citations

0
Ex-vivo antioxidant, enzyme inhibitory properties and computational analysis unveil the molecular mechanism of cardiac and penile phosphodiesterase-5 inhibition by bacterial strain HOKA1 extract as an aphrodisiac's agent DOI
Habeebat Adekilekun Oyewusi,

Oluwatosin Olubunmi Oladipo,

Hamdalat Folake Muritala

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 283, P. 137513 - 137513

Published: Nov. 16, 2024

Language: Английский

Citations

1
Ashwagandharishta compounds possess affinity interactions against diabetes-linked liver cancer: Implications from network pharmacology, molecular docking and dynamics simulations DOI

Annadurai Vinothkanna,

Ligang Chen,

Ragothaman Prathiviraj

et al.

South African Journal of Botany, Journal Year: 2024, Volume and Issue: 177, P. 26 - 49

Published: Dec. 2, 2024

Language: Английский

Citations

0