Published: Jan. 1, 2024
Language: Английский
CNS Drugs, Journal Year: 2024, Volume and Issue: 38(3), P. 205 - 224
Published: Feb. 29, 2024
Language: Английский
Citations
11
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102519 - 102519
Published: Sept. 1, 2024
Language: Английский
Citations
4
Journal of Neural Transmission, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 30, 2025
Language: Английский
Citations
0
Animal Cells and Systems, Journal Year: 2025, Volume and Issue: 29(1), P. 135 - 148
Published: Feb. 11, 2025
Circadian rhythms are 24-hour cycles in various biological processes, such as sleep, wake, and hormone secretion, controlled by an internal clock. Disruption of circadian has been related to human diseases. Abnormal expression rhythm-related genes, CLOCK, BMAL1, PER1, PER2, CRY1, CRY2, RORα, NPAS2, REV-ERBα TIMELESS also reported be associated with cancer. NPAS2 cancer development. In contrast, RORα inhibit development progression. Furthermore, studies suggest that genes can regulated ncRNAs miRNAs, lncRNAs circRNAs dysregulation these contributes Here, we summarize the mechanisms whereby ncRNA leads abnormal several cancers gene-associated regulatory contribute resistance chemo – radiotherapy. This review provides insights into mechanistic involvements network
Language: Английский
Citations
0
BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)
Published: Feb. 13, 2025
Sleep disturbance is a common condition in patients with schizophrenia. Studies have shown that insufficient sleep and excessive lead to adverse health outcomes. This study aimed identify the factors associated short long duration, as well prevalence of somatic comorbidities schizophrenia patients. was conducted 24 mental institutes Guangdong Province using multistage-stratified random sampling method. All information collected by face-to-face interview structured questionnaire. The association duration sociodemographic clinical determined multinomial logistic regressions. Subgroup analysis performed various source A total 6 024 were enrolled this study, among whom 8.6% (n = 521) reported 47.2% 2 850) had duration. most comorbid chronic diseases entire cohort hypertension (8.0%), diabetes (6.8%) hyperlipidemia (3.2%). Factors such as, current smoker, outpatients, benzodiazepines (BZDs), side effects, comorbidities, age onset, illness positively On other hand, personal annul income < 10 000 yuan, ≥ 40 patients, first-generation antipsychotics (FGAs) effects In outpatient settings, overweight whereas inpatient being female correlated Disruption are highly prevalent demonstrates complex relationships socioeconomic information, schizophrenia, highlighting need for developing targeted interventions management strategies Not applicable.
Language: Английский
Citations
0
BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)
Published: March 7, 2025
Several studies have indicated a potential association between obesity, depression, and sleep disorders. However, the role of depression in mediating relationship obesity disorders remains unclear. The Body Roundness Index (BRI), more precise anthropometric measure than traditional body mass index (BMI), is particularly effective assessing visceral fat levels. This study examines BRI disorders, with focus on whether influences this association. included data from 32,504 participants National Health Nutrition Examination Survey (NHANES) 2005–2018 cycle. was examined through subgroup analysis, restricted cubic spline (RCS) modeling, threshold effect multivariable logistic regression. Furthermore, predictive capabilities various indices—including BRI, weight-adjusted waist (WWI), BMI, weight—on disorder incidence were assessed using Receiver Operating Characteristic (ROC) curve analysis. Finally, Mediation analysis also performed to explore relationship. participants, whom 4,568 reported After adjusting for all covariates regression, each one-unit increase associated 13% higher prevalence (OR = 1.13, 95% CI: 1.09, 1.16) an 8% 1.08, 1.05, 1.11). Similar results obtained when divided into tertiles, significant trend (P < 0.05). RCS analyses revealed nonlinear prevalence, breakpoint 3.508. ROC that had superior capability compared indices, area under (AUC) 0.637 (95% CI, 0.628–0.645, P 0.001). further 14% mediated by Elevated levels linked acting as partial mediator These findings emphasize connection highlighting importance managing mitigate risk Not applicable.
Language: Английский
Citations
0
Journal of Clinical Laboratory Analysis, Journal Year: 2025, Volume and Issue: unknown
Published: March 10, 2025
ABSTRACT Objective Obstructive Sleep Apnea (OSA) is a common heterogeneous sleep disorder that significantly impacts the quality of individuals and leads to severe complications. Patients with OSA often experience disrupted circadian rhythm, hyperactive hypoxia response, endothelial dysfunction, yet underlying molecular mechanism remains poorly known. Recent research suggests promising evidence potential role SIRT1 in etiology OSA, warranting further investigation. Methods We investigated associations promoter variant (rs7895833A > G) severity 199 who underwent an overnight polysomnography at clinic. Results The minor allele frequency was observed as 0.309 males ( n = 149) 0.310 females 50). No significant were between genotypes apnea‐hypopnea index (AHI) entire sample. However, we association p 0.034) rs7895833‐G stratified by AHI. Additionally, found statistically inverse correlations age protein levels total sample 0.013) male group 0.018), suggesting age‐related expression SIRT1. Our analysis also confirmed published literature, showing AHI clinical parameters such age, BMI, Epworth sleepiness scale, neck circumference. Conclusions Overall, may indirectly affect pathogenesis, which might be influenced gender. Further detailed involving large population‐based biobanks, especially focusing on gender‐based differences, will improve our understanding management.
Language: Английский
Citations
0
Briefings in Bioinformatics, Journal Year: 2025, Volume and Issue: 26(2)
Published: March 1, 2025
Abstract Circadian rhythm plays a critical role in regulating various physiological processes, and disruptions these rhythms have been linked to wide range of diseases. Identifying molecular biomarkers showing differential circadian (DC) patterns between biological conditions or disease status is important for prevention, diagnosis, treatment. However, pattern characterized by three key components: amplitude, phase, MESOR, which poses great challenge DC analysis. Existing statistical methods focus on detecting shape (amplitude phase) but often overlook MESOR difference. Additionally, lack flexibility incorporate external knowledge such as information from similar clinical context improve the current To address limitation, we introduce novel Bayesian hierarchical model, BayesDCirc, designed two-group experimental design, offer advantage testing difference incorporating knowledge. Benefiting explicitly within modeling framework, BayesDCirc demonstrates superior FDR control over existing methods, with further performance improvement leveraging genes. Applied two real datasets, successfully identify genes, particularly incorporated. The R package “BayesDCirc” method publicly available GitHub at https://github.com/lichen-lab/BayesDCirc.
Language: Английский
Citations
0
Brazilian Journal of Health Review, Journal Year: 2024, Volume and Issue: 7(2), P. e69158 - e69158
Published: April 24, 2024
O objetivo desta revisão foi relatar o conhecimento atual sobre os principais sinais e sintomas as comorbidades que afetam indivíduos com esquizofrenia. As buscas foram realizadas através de pesquisas nas bases dados PubMed Central (PMC) Biblioteca Virtual Saúde (BVS). Foram utilizados três descritores em combinação termo booleano “AND”: Schizophrenia, Signs and Symptoms, Clinical Diagnosis. Desta busca encontrados 490 artigos, posteriormente submetidos aos critérios seleção. Dos quais, 419 artigos pertenciam à base 71 Saúde. Após a aplicação dos inclusão exclusão selecionados 24 na 1 artigo Saúde, sendo um total 25 estudos para compor coletânea. Os destacam relação entre transtornos psicóticos, como esquizofrenia depressão, ressaltando importância da pesquisa contínua colaboração interdisciplinar aprimorar diagnóstico tratamento dessas condições. A identificação biomarcadores uma compreensão mais profunda das características clínicas são cruciais desenvolver terapias eficazes, visando melhorar qualidade vida pacientes. integração abordagens colaborativas especialidades médicas uso tecnologias inovadoras, inteligência artificial aprendizado máquina, oferecem novas oportunidades precoce personalizado Em resumo, progresso no manejo condições complexas requer abordagem holística multidisciplinar, voltada atender às necessidades individuais pacientes promover seu bem-estar geral.
Citations
1
The Canadian Journal of Psychiatry, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 21, 2024
Objective The pathophysiological mechanisms influencing psychosis spectrum disorders are largely unknown. glymphatic system, which is a brain waste clearance pathway, has recently been implicated in its pathophysiology and also shown to be disrupted various neurodegenerative vascular diseases. Initial studies examining the system have reported disruptions, but findings confounded by medication effects as they included antipsychotic-treated patients. In this study, we used diffusion tensor imaging analysis along perivascular space (DTI-ALPS) technique measure functionality of sample antipsychotic-minimally exposed patients with healthy controls. Methods study 13 (2 weeks antipsychotic exposure past 3 months/lifetime) 114 We quantified water metrics x-, y-, z-axes both projection association fibres derive DTI-ALPS index, proxy for activity. Between-group differences were analyzed using two-way ANCOVA controlling age sex. Partial correlations assess between ALPS index clinical variables. Results Analyses revealed that disorder had lower value than controls hemispheres whole (all P < 0.005). Significant observed x y projections/associations ( 0.001). Furthermore, did not find any significant > 0.05) age, body mass symptomatology, metabolic parameters. Conclusion This shows dysregulated disorders. Understanding influence may help understand proper needed normal functioning.
Language: Английский
Citations
1