Loss of normal facial asymmetry in schizophrenia and bipolar disorder: implications for development of brain asymmetry in psychotic illness

Psychiatry Research, Journal Year: 2024, Volume and Issue: 342, P. 116213 - 116213

Published: Sept. 23, 2024

Development of the craniofacies occurs in embryological intimacy with development brain and both show normal left-right asymmetries. While facial dysmorphology to excess psychotic illness, asymmetry has yet be investigated as a putative index asymmetry. Ninety-three subjects (49 controls, 22 schizophrenia, bipolar disorder) received 3D laser surface imaging face. On geometric morphometric analysis (x, y, z) visualisations statistical models for asymmetries, controls upper face periorbital region, which share forebrain, showed marked Their geometry included: along x-axis, rightward its dorsal-medial aspects leftward ventral-lateral aspects; z-axis, anterior protrusion right aspect. In schizophrenia disorder these asymmetries were diminished, residual retention disorder. This shows commonalities that frontal lobe These findings indicate trans-diagnostic process involves loss Embryologically, they implicate face-brain across gestational weeks 7-14 processes involve genes previously associated risk schizophrenia.

Language: Английский

What is the duration of untreated psychosis worldwide?

Psychological Medicine, Journal Year: 2024, Volume and Issue: 54(13), P. 3755 - 3757

Published: Sept. 26, 2024

Language: Английский