Primary Prevention Strategy for Non-Communicable Diseases (NCDs) and Their Risk Factors: The Role of Intestinal Microbiota DOI Creative Commons

Itzel Ivonn López-Tenorio,

Óscar Rodrigo Aguilar-Villegas,

Yoshua Espinoza-Palacios

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2529 - 2529

Published: Nov. 5, 2024

Non-communicable diseases (NCDs) are the leading cause of morbidity and mortality worldwide. These conditions have numerous health consequences significantly impact patients' lifestyles. Effective long-term treatment is essential since NCDs irreversible. Therefore, primary healthcare must be both exclusive highest quality, ensuring comprehensive care. The goal should to improve quality life with a focus on patients, families, communities, as most these can prevented controlled, although not cured. Several factors been linked individual health, including social, cultural, economic aspects, lifestyle, certain environmental factors, work, that positive or negative effects. More variables may contribute onset NCDs, which defined by their chronic nature, propensity for prolongation, generally slow rate progression. Examples include hypertension, type 2 diabetes (T2D), dyslipidemia, fatty liver disease metabolic dysfunction. has associated an imbalance in microbial niches, such gut, hosts billions microorganisms performing multiple functions, production metabolites like bile acids (BAs), short-chain (SCFAs), trimethylamine N-oxide (TMAO). lifestyle changes personal habits gut microbiota (GM), potentially preventing metabolism. highly prevalent worldwide, prompting increased attention strategies modifying intestinal (IM). Approaches probiotics, prebiotics, synbiotics, fecal transplantation (FMT) demonstrated improvements individuals conditions. Additionally, adoption healthy IM help prevent related main aim this review analyze understand importance intervention prevention non-communicable diseases. R3:A1.

Language: Английский

MO-GCN: A multi-omics graph convolutional network for discriminative analysis of schizophrenia DOI Creative Commons
Haiyuan Wang,

Runlin Peng,

Yuanyuan Huang

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: 221, P. 111199 - 111199

Published: Jan. 7, 2025

The methodology of machine learning with multi-omics data has been widely adopted in the discriminative analyses schizophrenia, but most these studies ignored cooperative interactions and topological attributes networks. In this study, we constructed three types brain graphs (BGs), gut (GGs), nine brain-gut combined (BGCGs) for each individual. We proposed a novel graph convolutional network (MO-GCN) an attention mechanism to construct classification model by integrating all BGCGs. also identified important features using Topk pooling layer analyzed their correlations Positive Negative Syndrome Scale (PANSS) MATRICS Consensus Cognitive Battery (MCCB) scores. results showed that MO-GCN BGCGs outperformed GCN models either BGs or GGs. particular, accuracy best 5-fold cross-validation reached 84.0%. Interpretability analysis revealed top 10 were primarily from hippocampus, olfactory, fusiform pallidum, which involved systems memory, emotion. Dorea, Ruminococcus, Subdoligranulum Clostridium, etc. Moreover, significantly correlated PANSS MCCB scores, respectively. conclusion, can effectively improve performance provide potential microbiota-brain perspective understanding schizophrenia.

Language: Английский

Citations

2
Inulin alleviates chronic ketamine-induced impairments in memory and prepulse inhibition by regulating the gut microbiota, inflammation, and kynurenine pathway DOI

Zhilong Xu,

Haoyang Lu, Chen Hu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 294, P. 139503 - 139503

Published: Jan. 5, 2025

Language: Английский

Citations

0
The role of ferroptosis and oxidative stress in cognitive deficits among chronic schizophrenia patients: a multicenter investigation DOI Creative Commons
Zhenlei Peng, Qiyu Jia,

Junxiong Mao

et al.

Schizophrenia, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 11, 2025

Oxidative stress (OS) is crucial in schizophrenia (SCZ) pathology. Ferroptosis, a recently discovered cell death pathway linked to OS, might contribute the development of SCZ. This study investigated association between ferroptosis markers and cognitive impairments chronic SCZ patients. A retrospective analysis was conducted on 204 patients with deficits 216 healthy controls (HC) matched for relevant characteristics. Plasma levels OS markers, including iron, ferritin (FE), transferrin (TF), glutathione peroxidase 4 (GPX4), long-chain acyl-CoA synthetase (ACSL4), (GSH), sirtuin 1 (SIRT1), nuclear factor erythroid 2-related 2 (Nrf2), malondialdehyde (MDA), superoxide dismutase (SOD) were measured. Standardized assessments like positive negative syndrome scale (PANSS), Montreal Cognitive Assessment (MoCA) used evaluate psychiatric symptoms, function. showed significant differences compared HC group (P < 0.01). Multiple linear regression revealed that decreased GSH iron levels, along elevated SOD significantly associated overall severity symptoms. Additionally, reduced GPX4 increased ACSL4 FE symptoms impairments. Notably, emerged as key predictor function abstraction language domains. Our alterations altered plasma GPX4, GSH, ACSL4, FE, patients, which indicate close biomarkers observed these individuals.

Language: Английский

Citations

0
Progress in the study of oxidative stress damage in patients with schizophrenia: challenges and opportunities DOI Creative Commons

K Zhang,

Lijing Zou, Yi Cai

et al.

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 21, 2025

Schizophrenia is a serious psychiatric disorder of multifactorial triggers, with lifetime prevalence about 1% in all countries the world, slightly higher males than females, and peak incidence between ages 15-35 years old, poor prognosis for most patients, which imposes heavy burden on society family. Early intervention important regression patients. More more studies have found that imbalance oxidation antioxidant, persistent damage to brain by oxidative stress play an role occurrence development schizophrenia. Antioxidants, as additive therapy, improving symptoms well preventing relapse patients This paper intends address pathogenesis injury schizophrenia, significance treatment

Language: Английский

Citations

0
Investigating the Effect of N-Acetyl Cysteine on Positive, Negative, and Cognitive Symptoms of Patients with Schizophrenia: A Clinical Trial DOI Open Access

Atefe Soheilipour,

Fateme Rajabi, Mohammad Reza Maracy

et al.

Iranian Journal of Psychiatry and Behavioral Sciences, Journal Year: 2025, Volume and Issue: 19(1)

Published: Feb. 9, 2025

Background: Recent studies have identified oxidative stress as a potential neurobiological contributor to the development of schizophrenia. N-acetylcysteine (NAC) is recognized for its potent antioxidant and neuroprotective properties. Objectives: This study aimed evaluate efficacy NAC in reducing treatment Methods: randomized, double-blind, placebo-controlled, parallel-group involved 35 patients with Patients case group received 600 mg once daily addition their routine treatment, while control continued placebo instead NAC. Assessments were conducted using Scale Assessment Positive Symptoms (SAPS), Negative (SANS), neuropsychiatry unit cognitive assessment tool (NUCOG) at baseline, 1 2 months post-treatment. Results: resulted significant improvement SAPS NUCOG indices, well an increase peripheral glutathione (GSH) levels (P < 0.05). Continued use second month positively affected particularly Visuo-constructional variable. No impact on SANS was observed. The limited side effects during period suggest it safe practical option. Conclusions: add-on therapy significantly improved positive symptoms functions schizophrenia but did not affect negative symptoms.

Language: Английский

Citations

0
Altered serum glutathione disulfide levels in acute relapsed schizophrenia are associated with clinical symptoms and response to electroconvulsive therapy DOI Creative Commons

Li Xu,

Ping Yu, Haidong Yang

et al.

BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 14, 2025

The pathophysiological mechanisms of schizophrenia are complex and not fully elucidated. This study aimed to investigate changes total glutathione (T-GSH), disulfide (GSSG), reduced (GSH), the GSH/GSSG ratio before after electroconvulsive therapy (ECT) for patients with acute relapse associations clinical symptoms. cohort included 110 55 healthy controls. All received 8–10 sessions ECT. Clinical symptoms were assessed using Positive Negative Syndrome Scale (PANSS). As compared controls, had decreased baseline GSSG levels (t = -2.115, p 0.036) elevated ratios 2.141, 0.034). Baseline negatively correlated both PANSS scores (beta -0.369, t -4.108, < 0.001) positive symptom -0.332, -3.730, 0.001), while positively improvements in (r 0.392, 0.293, 0.005) ECT treatment. In treatment responders, significantly increased -2.817, 0.006) 4.474, as ECT, T-GSH (B 0.734, OR 2.083, 95%CI:1.287–3.372, 0.003), -2.720, 0.066, 95%CI:0.011–0.390, -1.013, 0.363, 95%CI:0.142–0.930, 0.035) predictive improvement. Patients exhibit significant redox imbalance, may serve a potential biomarker evaluate predict outcomes.

Language: Английский

Citations

0
High-cellulose diet ameliorates cognitive impairment by modulating gut microbiota and metabolic pathways in mice DOI
Moeka Tanabe, Kazuo Kunisawa, Isao Saito

et al.

Journal of Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Exploring the relationship between the gut microbiota and cognitive function in schizophrenia patients with distinct weights DOI

Baoyuan Zhu,

Liqin Liang,

Yuanyuan Huang

et al.

Schizophrenia Research, Journal Year: 2025, Volume and Issue: 280, P. 103 - 113

Published: April 24, 2025

Language: Английский

Citations

0
Exploratory Analysis of Gut Microbiota Profile in Duchenne Muscular Dystrophy (DMD) Patients with Intellectual Disability DOI Creative Commons
Chiara Panicucci, Sara Casalini, Giovanni Fiorito

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Abstract This study investigates the differences in gut microbiota composition between DMD patients with (DMD +) and without −) intellectual disability (ID) its potential role cognitive outcomes. In this study, we assessed 50 genetically confirmed (median age 13.1 years) using 16S rRNA gene sequencing. Cognitive assessment was performed Wechsler Intelligence Scales, ID defined as an IQ < 70. Stool samples were analyzed, statistical methods used to assess alpha- beta-diversity. Thirty-four percent of had ID. No significant found alpha-diversity or Firmicutes/Bacteroidetes ratio. However, beta-diversity analysis revealed + − groups, including, , increased abundance Propionibacterium Bifidobacterium a reduction Bulleidia . These bacteria are involved metabolic pathways that can influence neurological health through gut-brain axis, particularly via production short-chain fatty acids. While these preliminary findings suggest possible association profile impairment DMD, further research is needed explore causal relationship consider microbiota-targeted therapeutic strategies.

Language: Английский

Citations

0
Primary Prevention Strategy for Non-Communicable Diseases (NCDs) and Their Risk Factors: The Role of Intestinal Microbiota DOI Creative Commons

Itzel Ivonn López-Tenorio,

Óscar Rodrigo Aguilar-Villegas,

Yoshua Espinoza-Palacios

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2529 - 2529

Published: Nov. 5, 2024

Non-communicable diseases (NCDs) are the leading cause of morbidity and mortality worldwide. These conditions have numerous health consequences significantly impact patients' lifestyles. Effective long-term treatment is essential since NCDs irreversible. Therefore, primary healthcare must be both exclusive highest quality, ensuring comprehensive care. The goal should to improve quality life with a focus on patients, families, communities, as most these can prevented controlled, although not cured. Several factors been linked individual health, including social, cultural, economic aspects, lifestyle, certain environmental factors, work, that positive or negative effects. More variables may contribute onset NCDs, which defined by their chronic nature, propensity for prolongation, generally slow rate progression. Examples include hypertension, type 2 diabetes (T2D), dyslipidemia, fatty liver disease metabolic dysfunction. has associated an imbalance in microbial niches, such gut, hosts billions microorganisms performing multiple functions, production metabolites like bile acids (BAs), short-chain (SCFAs), trimethylamine N-oxide (TMAO). lifestyle changes personal habits gut microbiota (GM), potentially preventing metabolism. highly prevalent worldwide, prompting increased attention strategies modifying intestinal (IM). Approaches probiotics, prebiotics, synbiotics, fecal transplantation (FMT) demonstrated improvements individuals conditions. Additionally, adoption healthy IM help prevent related main aim this review analyze understand importance intervention prevention non-communicable diseases. R3:A1.

Language: Английский

Citations

1