Common and unique white matter fractional anisotropy patterns in patients with schizophrenia with medication-resistant auditory verbal hallucinations: a retrospective tract-based spatial statistics study

Schizophrenia, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 20, 2025

Auditory verbal hallucinations (AVHs) are experienced by the majority of patients with schizophrenia and often resistant to treatment antipsychotic agents. White matter (WM) tract abnormalities associated AVH efficacy. Using a retrospective design, 115 AVHs, 48 medication-resistant AVHs 67 treatable 70 healthy controls (HCs) were selected from database our cohort study for 5-year follow-up assessment. WM integrity was measured using tract-based spatial statistics (TBSS) at baseline after 5 years agent treatment. The fractional anisotropy (FA) value used demonstrate alterations in HCs. Our data demonstrated that showed significantly greater FA values corpus callosum (CC) fasciculus corticospinal post-treatment compared HCs, but difference CC no longer significant group exhibited superior longitudinal Compared HC group, visual radiation In groups, common noted, as observed group. At same time, distinct fasciculus, which may contribute whereas both AVHs. decrease posterior observation baseline. summary, treatment-resistant have tract.

Language: Английский

Self-disturbance in schizophrenia: Updating the research and bridging the gaps

Schizophrenia Research, Journal Year: 2024, Volume and Issue: 274, P. 489 - 491

Published: Nov. 8, 2024

Language: Английский