Cannabidiol reverses microglia activation and loss of parvalbumin interneurons and perineuronal nets in a mouse model of schizophrenia DOI Creative Commons

Naielly Rodrigues da Silva,

Davide Gobbo, Felipe V. Gomes

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 22, 2024

Abstract Cannabidiol (CBD) has shown potential for treating schizophrenia (SCZ) by targeting its positive, negative, and cognitive symptoms. In this study, we investigated if CBD could reverse the memory impairment observed after chronic administration of NMDA receptor antagonist. MK-801 treatment (0.5 mg/kg i.p., twice a day, 14 days) resulted in short- long-term deficits decreased relative power γ oscillation freely moving animals. (60 i.p. daily seven days period) reversed these changes. The positive effects were prevented 5-HT1A, but not CB2, On cellular level, MK-801-induced reduced number parvalbumin-positive neurons their associated perineuronal nets prelimbic medial prefrontal cortex (mPFC) ventral hippocampus (vHip). This neuroprotective effect was mediated 5-HT1A CB2 receptors vHip independent mPFC. Additionally, microglial activation both mPFC vHip, again through receptors. These findings suggest that modulates multiple pathways affected SCZ-like conditions, offering promising therapeutic avenue SCZ treatment. Chemical compounds studied article (PubChem CID: 644019), 180081), AM630 4302963), WAY100635 11957721).

Language: Английский

The Role of Perineuronal Nets in Physiology and Disease: Insights from Recent Studies DOI Creative Commons

Sophia Auer,

Martin Schicht, Lucas Hoffmann

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(5), P. 321 - 321

Published: Feb. 20, 2025

Perineuronal nets (PNNs) are specialized extracellular matrix structures that predominantly surround inhibitory neurons in the central nervous system (CNS). They have been identified as crucial regulators of synaptic plasticity and neuronal excitability. This literature review aims to summarize current state knowledge about PNNs, their molecular composition structure, well functional roles involvement neurological diseases. Furthermore, future directions PNN research proposed, therapeutic potential targeting PNNs develop novel treatment options for various disorders is explored. emphasizes importance CNS physiology pathology underscores need further this area.

Language: Английский

Citations

0
Altered volume of thalamic nuclei and genetic expression in first-episode psychotic patients, and their association with childhood adversity DOI Creative Commons

Uriel K.A. Elvira,

Olga Rivero,

Alba Postiguillo

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111371 - 111371

Published: April 1, 2025

Language: Английский

Citations

0
Cannabidiol reverses microglia activation and loss of parvalbumin interneurons and perineuronal nets in a mouse model of schizophrenia DOI Creative Commons

Naielly Rodrigues da Silva,

Davide Gobbo, Felipe V. Gomes

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 22, 2024

Abstract Cannabidiol (CBD) has shown potential for treating schizophrenia (SCZ) by targeting its positive, negative, and cognitive symptoms. In this study, we investigated if CBD could reverse the memory impairment observed after chronic administration of NMDA receptor antagonist. MK-801 treatment (0.5 mg/kg i.p., twice a day, 14 days) resulted in short- long-term deficits decreased relative power γ oscillation freely moving animals. (60 i.p. daily seven days period) reversed these changes. The positive effects were prevented 5-HT1A, but not CB2, On cellular level, MK-801-induced reduced number parvalbumin-positive neurons their associated perineuronal nets prelimbic medial prefrontal cortex (mPFC) ventral hippocampus (vHip). This neuroprotective effect was mediated 5-HT1A CB2 receptors vHip independent mPFC. Additionally, microglial activation both mPFC vHip, again through receptors. These findings suggest that modulates multiple pathways affected SCZ-like conditions, offering promising therapeutic avenue SCZ treatment. Chemical compounds studied article (PubChem CID: 644019), 180081), AM630 4302963), WAY100635 11957721).

Language: Английский

Citations

0