Nanotechnology Reviews,
Journal Year:
2023,
Volume and Issue:
12(1)
Published: Jan. 1, 2023
Abstract
Novel
CuO–FeS
nanocomposites
were
synthesized
to
exert
anticancer
effects
on
HepG2
cells.
The
formation
was
initially
demonstrated
using
UV–Visible
spectrophotometry
analysis,
which
indicated
two
peaks
at
335
and
370
nm.
Characteristic
Fourier
transform
infrared
spectroscopy
for
Cu–O
Fe–S
bonds
observed
516,
577
619
cm
−1
in
addition
other
notable
peaks.
Miller
indices
correspond
the
lattice
spacing
of
monoclinic
CuO
FeS
as
by
selected
area
diffraction
rings
concurrent
with
X-ray
observations.
morphology
interpreted
scanning
electron
microscopy
transmission
microscopy,
indicating
a
particle
size
110
As
per
energy-dispersive
strong
Cu
(0.9,
8
9
keV),
Fe
(6–7
O
(0.5
keV)
S
(2.5
blend
no
impurities.
A
mean
121.9
nm
polydispersity
index
0.150
displayed
dynamic
light
scattering
analysis
zeta
potential
−29.2
mV.
composites
not
toxic
normal
3T3-L1
cells
haemolytic
even
higher
doses.
In
addition,
stable
exerted
cytotoxic
(IC
50
=
250
±
5.7
μg/mL)
induced
cell
death
creating
loss
mitochondrial
membrane
induction
apoptosis
ROS-independent
manner.
Results in Engineering,
Journal Year:
2024,
Volume and Issue:
22, P. 102329 - 102329
Published: May 29, 2024
Lung
cancer
is
the
foremost
diagnosed
in
men
and
second
most
common
worldwide,
highlighting
need
for
new
treatment
strategies.
In
current
study,
AgZnO
bimetallic
nanoparticles
(NPs)
with
average
size
of
11
nm
were
successfully
synthesized
using
Salvia
officinalis
(SO)
extract.
The
as-synthesized
NPs
characterized
by
several
microscopic
spectroscopic
techniques.
distribution
nanoparticle
curve
was
ranged
from
10
to
20
nm,
particle
diameter
approximately
15.6±4.3
zeta
potential
value
-31.1±5.2
mV.
Also,
EDX
technique
revealed
that
weight
percentage
Zn,
O,
Ag
5.9
%,
3.6
90.5
respectively.
cytotoxicity
assessed
against
A549
lung
cells
human
non-tumorigenic
epithelial
BEAS-2B
cells.
showed
biocompatibility
heathy
cells,
while
they
high
addition,
demonstrated
higher
compared
AgNPs
SO
extract,
indicating
synergistic
effect
between
ZnO
structure
nanoparticle.
apoptosis
necrosis
extract
11.6%
(3.69%
early
8.07%
late
apoptosis)
2.79%,
On
other
hand,
29.74%
(5.04%
24.7%
9.09%,
found
through
apoptosis,
owing
upregulation
proapoptotic
genes
(caspase-3,
caspase-8,
caspase-9,
P21,
BAX)
downregulation
antiapoptotic
migration
(BCL2,
cyclin
E,
D1,
MMP-2,
MMP-9)
treated
illustrated
lower
ability
those
S.
role
NP
cytotoxicity.
arrested
during
sub-G1
phase
increased
significantly
after
(p
<
0.05)
(17.8%
38%
NPs).
results
this
study
prove
enhanced
anticancer
due
which
could
be
further
investigated
application.
Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 26, 2024
Introduction
Evaluating
the
anticancer
property
of
Padina
boergesenii
mediated
bimetallic
nanoparticles.
Methods
The
present
study
focuses
on
synthesizing
Se-ZnO
nanoparticles
from
an
aqueous
algal
extract
brown
algae
.Synthesized
NPs
were
characterized
by
UV,
FTIR,
SEM-EDS
and
HRTEM
for
confirmation
along
with
activity
MTT
assay.
Results
UV
gave
absorbance
peak
at
342
370
nm,
FTIR
showed
functional
groups
involved
in
NPs.
TEM
micrographs
indicated
crystalline
nature
confirmed
size
to
be
average
26.14
nm.
Anticancer
efficacy
against
MCF-7
breast
HepG2
(hepatoblastoma)
cell
lines
also
demonstrated,
attaining
IC
50
value
67.9
µg
74.9
µg/ml
respectively,
which
caused
50%
death.
Discussion
This
work
aims
highlight
effective
method
delivering
bioactive
compounds
extracted
emphasize
its
future
therapeutic
prospects.
potential
Selenium-Zinc
oxide
is
great
interest
due
biocompatibility
low
toxicity
aspects
selenium
combined
cost-effectiveness
sustainability
zinc
metal.
presence
contributed
stability
acted
as
capping
properties.
ACS Applied Nano Materials,
Journal Year:
2023,
Volume and Issue:
6(23), P. 21462 - 21495
Published: Nov. 29, 2023
The
concept
of
theranostics
is
ground
breaking
in
the
area
cancer
remedy
due
to
its
capability
integrate
both
therapeutic
and
diagnostic
elements
a
single
approach.
This
approach
advantageous
diagnose
assess
treatment
simultaneously
enabling
identification
optimum
course.
process
includes
real-time
monitoring
strategies
through
simultaneous
delivery
imaging
agents.
Nanocarriers
or
nanomaterials
play
vital
role
theranostic
applications
therapy.
dual
task
provides
various
challenges.
Imaging
modalities
are
engineered
enhance
signal-to
noise
ratios
while
being
rapidly
eliminated.
high-concentration
accumulation
curatives
at
site
disease
biocompatibility
nanocarriers
two
important
concerns
considered
for
design
nanostructures.
Various
have
been
integrated
with
other
materials
form
composite
efficacy
along
diagnosing
ability.
In
this
report,
overview
metal,
ceramic,
polymer,
small-molecule-based
nanoparticulate
systems
presented
applications.
RSC Advances,
Journal Year:
2023,
Volume and Issue:
13(30), P. 20856 - 20867
Published: Jan. 1, 2023
Bimetallic
nanoparticles
have
received
much
attention
recently
due
to
their
multifunctional
applications,
and
synergistic
potential
at
low
concentrations.
In
the
current
study,
bimetallic
boron
oxide-zinc
oxide
(B2O3-ZnO
NPs)
were
synthesized
by
an
eco-friendly,
cost-effective
method
through
utilization
of
gum
arabic
in
presence
gamma
irradiation.
Characterization
B2O3-ZnO
NPs
revealed
successful
synthesis
on
nano-scale,
good
distribution,
addition
formation
a
stable
colloidal
nano-solution.
Furthermore,
assessed
for
anticancer,
antimicrobial
antioxidant
activities.
The
evaluation
cytotoxicity
Vero
Wi38
normal
cell
lines
illustrated
that
are
safe
use
where
IC50
was
384.5
569.2
μg
ml-1,
respectively.
had
anticancer
activity
against
Caco
2
80.1
ml-1.
exhibited
promising
antibacterial
E.
coli,
P.
aeruginosa,
B.
subtilis
S.
aureus,
MICs
125,
62.5,
125
62.5
ml-1
Likewise,
antifungal
C.
albicans
as
unicellular
fungi
(MIC
ml-1).
Moreover,
displayed
(IC50
102.6
conclusion,
novel
successfully
using
under
radiation,
they
Bioresources and Bioprocessing,
Journal Year:
2025,
Volume and Issue:
12(1)
Published: April 12, 2025
The
biosynthesis
of
bimetallic
nanoparticles
using
plant
extracts
has
garnered
significant
attention
due
to
their
eco-friendly
and
cost-effective
nature.
This
study
aimed
biosynthesize
magnesium
oxide-zinc
oxide
nanocomposite
(MgO-ZnO
nanocomposite)
Pluchea
indica
leaf
extract
for
the
first
time,
with
a
focus
on
characterizing
its
physicochemical
properties
evaluating
biological
activities.
biosynthesized
MgO-ZnO
was
fully
characterized,
revealing
an
absorbance
peak
at
300
nm
UV-vis
spectroscopy.
Transmission
electron
microscopy
(TEM)
confirmed
particle
stability
within
size
range
5-35
nm.
Cytotoxicity
analysis
Wi
38
normal
cell
line
demonstrated
IC50
value
179.13
µg/mL,
indicating
good
biosafety.
exhibited
potent
anticancer
activity,
values
73.61
µg/mL
31.25
against
Hep-G2
MCF-7
cancer
lines,
respectively.
Antibacterial
assays
revealed
activity
Klebsiella
pneumoniae,
Escherichia
coli,
Bacillus
cereus,
Staphylococcus
aureus,
Candida
albicans,
minimum
inhibitory
concentrations
(MICs)
ranging
from
250
µg/mL.
Furthermore,
displayed
antioxidant
175
as
determined
by
DPPH
assay.
In
conclusion,
successful
synthesis
P.
demonstrates
potential
safe
effective
agent
concentration-dependent
antioxidants,
antibacterial,
applications.
highlights
versatility
plant-mediated
in
developing
functional
nanomaterials
biomedical
use.
Journal of King Saud University - Science,
Journal Year:
2024,
Volume and Issue:
36(7), P. 103243 - 103243
Published: May 8, 2024
Utilizing
plant
extracts
in
the
green
synthesis
of
bimetallic
nanoalloys
receives
more
attention
due
to
its
eco-friendly,
cheap,
single-step,
easy-handling
method,
producing
highly
active
and
biocompatible
nanoalloys.
Therefore,
aqueous
extract
ginger
rhizome
was
used
form
gold/silver
(Au/Ag)
There
were
37.3
mg.g−1
total
soluble
carbs,
0.75
proteins,
0.03
phenolic
compounds
quantified
rhizome.
The
production
BAu/Ag-NPs
relies
on
these
components.
as-formed
characterized
using
UV–Vis
spectroscopy.
results
showed
that
peak
surface
plasmon
resonance
(SPR)
occurred
between
440
545
nm.
existence
several
functional
groups
involved
reduction
stability
generated
shown
by
Fourier-transform
infrared
(FT-IR).
nanoalloys,
with
an
average
size
49.1
±
16.2
nm,
observed
be
spherical
transmission
electron
microscopy
(TEM).
Energy-dispersive
X-ray
(EDX)
indicated
synthesized
nanoalloy
mainly
consisted
Au
Ag
ions,
which
made
up
(31.2
%
47.1
%)
(45.9
28.6
sample's
atomic
weight
percentages,
respectively.
crystallography
confirmed
XRD
analysis.
When
examined
for
their
capacity
suppress
viral
replication,
remarkable
results,
78.2
inhibition
against
HAV
69.6
Cox-B4.
In
addition,
anticancer
activity
oral
epithelial
cells
(OEC),
MCF7
adenocarcinoma
cells,
HepG2
hepatocarcinoma
investigated
MTT
assay
method.
While
exhibited
moderate
toxicity
towards
normal
OEC
(IC50:
502.5
2.8
g.mL−1),
they
substantial
cytotoxicity
cancer
HepG2,
IC50
values
212.6
4.4
117.9
6.6
µg.mL−1,
According
data,
BAu/Ag
show
potential
as
antiviral
drugs
selectively
kill
cells.
