Plants,
Journal Year:
2025,
Volume and Issue:
14(3), P. 364 - 364
Published: Jan. 25, 2025
This
study
successfully
optimized
two
advanced
extraction
methods,
microwave-assisted
(MAE)
and
ultrasound-assisted
(UAE),
for
the
efficient
rapid
recovery
of
quinine
from
Cinchona
officinalis.
Among
evaluated
parts
plant,
bark
consistently
yielded
highest
concentration,
highlighting
its
significance
as
primary
source
alkaloid
extraction.
The
conditions
MAE
(65%
ethanol,
130
°C,
34
min)
achieved
a
maximum
yield
3.93
±
0.11
mg/g,
while
UAE
(61%
25
15
provided
faster
but
slightly
lower
2.81
0.04
mg/g.
These
findings
confirm
superiority
over
conventional
methods
like
Soxhlet
in
terms
time
efficiency
sustainability.
quantification
using
high-performance
liquid
chromatography
(HPLC)
coupled
with
detection
further
validated
reliability
reproducibility
results.
While
this
focused
on
optimizing
parameters,
it
sets
groundwork
future
research
into
sustainable
utilization
potential
valorization
C.
officinalis
byproducts.
not
only
provide
standardized
protocol
extracting
also
contribute
to
broader
application
green
chemistry
principles
pharmaceutical
production.
Plants,
Journal Year:
2025,
Volume and Issue:
14(5), P. 755 - 755
Published: March 1, 2025
This
review
highlights
the
recent
advancements
in
extraction
techniques
for
bioactive
compounds
from
natural
sources,
focusing
on
methodologies
that
enhance
both
efficiency
and
sustainability.
Techniques
such
as
pressurized
hot
water
(PHWE),
solid-state
fermentation
(SSF),
ionic
liquids
(ILs),
electrohydrodynamic
(EHD)
methods
have
shown
significant
potential
improving
yields
while
preserving
bioactivity
of
target
compounds.
These
innovative
approaches
offer
advantages
over
traditional
methods,
including
reduced
energy
consumption,
minimal
environmental
impact,
ability
to
extract
thermosensitive
PHWE
EHD
are
particularly
effective
extracting
antioxidants
compounds,
whereas
SSF
provides
an
environmentally
friendly
alternative
by
valorizing
agro-industrial
waste.
Ionic
liquids,
although
promising
complex
phytochemicals,
face
challenges
related
scalability
economic
feasibility.
The
adoption
these
advanced
represents
a
shift
toward
more
sustainable
cost-effective
processes,
promoting
discovery
utilization
high-value
also
contribute
development
eco-friendly,
strategies
align
with
green
chemistry
principles
regulatory
standards.
However,
further
research
technological
required
address
existing
limitations
ensure
widespread
application
industrial
pharmaceutical
sectors.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 20, 2025
Myrsine
africana
L.
is
a
member
of
the
Myrsinaceae
family,
which
encompasses
more
than
1,000
species
and
35
genera
predominantly
found
in
tropical
subtropical
regions.
This
plant
abundant
Africa
Asia,
has
been
traditionally
utilized
for
its
aromatic
properties
tea,
spices,
appetizers,
carminatives,
flavoring
agents.
Despite
wide-ranging
applications,
comprehensive
review
phytochemical
potential
biological
effects
not
yet
conducted.
study
aims
to
fill
that
gap
by
reviewing
composition
activities
M.
.
Literature
was
gathered
using
databases
such
as
Google
Scholar,
PubMed,
Scopus,
Web
Science.
The
wide
range
uses
can
be
attributed
rich
phytochemicals,
including
alkaloids,
flavonoids,
phenols,
terpenoids,
saponins.
Among
significant
activities,
known
anti-inflammatory
antioxidant
properties.
Furthermore,
it
shows
antispasmodic,
antityrosinase,
antibacterial,
anti-aging,
anticancer
applications.
Additionally,
used
treat
conditions,
malaria,
helminthosis,
wounds,
tuberculosis,
gastrointestinal
complications.
Some
isolated
compounds
from
different
parts
include
methylvilangin
(11)
,
methylanhydrovilangin
(12)
2-hydroxychrysophanol
(13)
myrsinene
(25)
myrsigenin
(26)
myrsininone
A
(27)
B
(28)
myrsinoside
(30)
well
various
other
flavonoid
compounds.
systematically
explore
profiles
associated
highlighting
key
their
pharmacological
implications.
By
bringing
together
information,
emphasizes
drug
discovery
future
research.
Asian Journal of Chemistry,
Journal Year:
2025,
Volume and Issue:
37(4), P. 745 - 757
Published: March 29, 2025
The
application
of
click
chemistry
in
the
synthesis
intricate
carbohydrate
derivatives
has
revolutionized
domains
chemical
biology
and
synthetic
chemistry.
This
review
examines
function
chemistry,
namely
copper(I)-catalyzed
azide-alkyne
cycloaddition
(CuAAC),
effectively
altering
structures
producing
practical
glycoconjugates.
Carbohydrates
are
essential
several
biological
functions,
such
as
cellular
recognition
immunological
responses,
however,
their
complicated
structure
makes
production
difficult.
Click
provides
an
optimal
answer
to
these
issues
due
its
simplicity,
high
yields
bioorthogonality.
methodology
been
extensively
used
advancement
glycoproteins,
glycodendrimers
glycopeptides,
which
play
a
crucial
role
fields
drug
discovery,
vaccine
development
diagnostics.
In
addition,
facilitated
biodegradable
polymers
glycomacromolecules
that
have
potential
be
materials
science,
for
sustainable
smart
technology.
flexibility
accuracy
CuAAC
carbohydrate-based
new
opportunities
investigation,
stimulating
advancements
both
biomedicine
industrial
applications.
evaluation
also
emphasizes
capacity
expedite
multifunctional
therapeutic
drugs
target
ailments
like
cancer.
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(4), P. 423 - 423
Published: March 31, 2025
The
revalorization
of
artichoke
(Cynara
scolymus
L.)
by-products
is
a
promising
strategy
to
obtain
bioactive
compounds
with
antioxidant
properties,
supporting
circular
economy
approach.
This
study
compares
the
efficiency
an
enzymatic
pretreatment
followed
by
microwave-assisted
extraction
(EMAE),
ultrasound-assisted
(EUAE),
and
ultrasound-microwave-assisted
(EUMAE)
at
pilot
scale
for
recovering
compounds.
Extracts
were
purified
using
Diaion®
HP20
resin
phenolic-rich
fractions
enhanced
activity.
results
showed
that
EUAE
was
most
effective
technique,
achieving
total
phenolic
content
(TPC)
210.76
±
1.40
µmol
GAE/g
d.w.
yield
21.38%.
HPLC-MS
analysis
identified
14
major
compounds,
including
chlorogenic
acid
isomers
(60.73
mg/g
d.e.),
caffeic
(34.29
luteolin
rutinoside
(103.27
among
others,
which
contribute
extracts’
high
bioactivity.
potential
extracts
assessed
Folin–Ciocalteu
(F-C),
ABTS,
DPPH,
FRAP
assays.
exhibited
highest
activity
values,
F-C:
985.33
4.46
d.e.,
ABTS:
80.46
2.39
TE/g
DPPH:
87.03
1.11
FRAP:
184.99
2.52
d.e.
purification
process
further
TPC
activity,
enzyme–ultrasound-assisted
extraction—purified
extract
(EUAE-PE)
reaching
purity
50.71%
F-C
value
2981.35
12.16
