Science Bulletin, Journal Year: 2023, Volume and Issue: 68(19), P. 2142 - 2144
Published: Aug. 14, 2023
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1302 - 1302
Published: Feb. 3, 2025
Despite extensive research on aneurysm treatment and neurocritical care, aneurysmal subarachnoid hemorrhage (SAH) is still a life-threatening disease, often leaving survivors with lasting neurological cognitive impairments. Early brain injury (EBI) delayed cerebral ischemia (DCI) are the main contributors to damage, neuroinflammation being critical shared pathophysiological process. While numerous inflammatory markers their temporal profiles in cerebrospinal fluid (CSF) have already been identified, comparisons age- sex-matched controls limited. This study analyzed CSF from 17 SAH patients requiring an external ventricular drain (EVD) due symptomatic hydrocephalus, sampled days 4 10 post-ictus. An control group included cerebrovascularly healthy lumbar drains during aortic surgery. Chemokines cytokines were quantified using immunoassays. Significantly elevated across both time points MCP-1, CXCL-13, Eotaxin-1, CXCL-10, IL-8, MIF. MIP-1α MIP-1β showed significant differences at particular points, indicating distinct profile for each parameter. These findings highlight neuroinflammation’s key role intracranial systemic pathophysiology following SAH, emphasizing its complexity individual variability. Knowing demographic factors impact specific manifestations of processes, comparison meaningful.
Language: Английский
Citations
1
Neuroscience, Journal Year: 2025, Volume and Issue: 568, P. 27 - 37
Published: Jan. 11, 2025
Language: Английский
Citations
0
Neuroscience, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0
Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16
Published: March 31, 2025
Intracranial aneurysms (IAs) can lead to subarachnoid hemorrhage, a life-threatening event associated with high morbidity and mortality. Identifying individuals at elevated risk is crucial for guiding timely interventions improving patient outcomes. In this retrospective cohort study, 850 patients who received interventional or surgical treatment IAs between January 2018 2024 were included. Demographic data (e.g., age, sex), lifestyle factors, comorbidities recorded. Hematologic, biochemical, coagulation parameters measured evaluate their potential association IA rupture. A univariate logistic regression was first conducted, followed by multivariate backward stepwise approach derive the final predictive model. The model's performance assessed using area under receiver operating characteristic curve (AUC), calibration curves, decision analysis. Younger female sex, higher neutrophil count, lower hematocrit, markers of inflammation (including fibrinogen D-dimer) emerged as key factors. Electrolyte imbalances, such low potassium, lactate dehydrogenase also significantly optimized model achieved an AUC 0.815, good clinical utility indicated These findings highlight interplay demographic, inflammatory, metabolic, in determining rupture IAs. Incorporating these factors into practice may enhance early detection, guide targeted prevention strategies, ultimately improve outcomes high-risk individuals.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3316 - 3316
Published: April 2, 2025
Intracranial aneurysm (IA) is a common cerebrovascular disease in which sacral aneurysms occurring the Wills ring region can lead to devastating subarachnoid hemorrhage. Despite advances research, underlying mechanisms of IA formation and rupture remain incompletely understood, hindering early diagnosis effective treatment. This review comprehensively summarizes current landscape biomarkers, encompassing genetic markers, DNA, RNA, inflammatory molecules, oxidative stress proteins, extracellular matrix (ECM) components. Accumulating evidence suggests that various biomarkers are associated with different stages pathogenesis, including initiation, progression, rupture. Aberrant ECM composition remodeling have been observed patients, matrix-degrading enzymes implicated growth Biomarker research holds great potential for improving clinical outcomes. Future studies should focus on validating existing identifying novel ones, investigating their facilitate development personalized preventive therapeutic strategies IA.
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: April 10, 2025
Language: Английский
Citations
0
Neurosurgical Review, Journal Year: 2025, Volume and Issue: 48(1)
Published: May 16, 2025
Language: Английский
Citations
0
World Neurosurgery, Journal Year: 2024, Volume and Issue: 185, P. e484 - e490
Published: Feb. 22, 2024
Language: Английский
Citations
3
Frontiers in Neurology, Journal Year: 2023, Volume and Issue: 14
Published: Oct. 19, 2023
Intracranial aneurysm (IA) counts are increasing yearly, with a high mortality and disability after rupture. Current diagnosis treatment rely on costly equipment, lacking effective indicators for progression prediction specific drugs treatment. Recently, peripheral blood biomarkers, as common clinical test samples, reflecting the immune inflammatory state of body in real-time, have shown promise providing additional information risk stratification IA patients, which may improve their outcomes rupture through anti-inflammatory therapy. Therefore, this paper reviewed progress potential biomarkers IAs, including indicators, cytokines, lipids, aiming to aid individual management therapy aneurysms practices.
Language: Английский
Citations
8
iScience, Journal Year: 2024, Volume and Issue: 27(11), P. 111184 - 111184
Published: Oct. 17, 2024
Language: Английский
Citations
2