Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 8, 2024
AbstractBackground
Current
evidence
suggests
that
genetic
factors,
hemodynamic
abnormalities,
and
chronic
inflammation
of
the
vascular
wall
contribute
to
onset
intracranial
aneurysms
(IAs).
The
deposition
lipid
plaques
is
frequently
observed
in
walls
IAs.
Therefore,
objective
this
research
was
determine
causal
link
between
plasma
lipids
Methods
Genetic
instrumental
variables
for
179
were
acquired
from
a
genome-wide
association
study
(GWAS)
7174
unrelated
Finnish
individuals.
Outcome
data
individuals
with
IAs
retrieved
GWAS
involving
23
cohorts,
comprising
79,429
European
ancestry.
This
dataset
included
7,495
cases
71,934
controls.
Three
databases
utilized
implementation
Mendelian
Randomization
(MR)
analysis.
an
aSAH
group
5,140
71,952
controls,
uIA
2,070
An
inverse-variance
weighted
(IVW)
method
employed
as
key
analysis
method.
To
ensure
reliability
findings,
MR-Egger
regression,
weighted-median,
weighted-mode
methods
employed.
Sensitivity
analyses
Cochran’s
Q
test,
MR-Pleiotropy
RESidual
Sum
Outlier
(MR-PRESSO),
Radial
MR
intercept
Leave-one-out
(LOO)
MR-Steiger
test
conducted
avoid
reverse
causality.
Results
Following
rigorous
screening,
tests,
Bonferroni
correction,
genetically
predicted
level
Phosphatidylethanolamine(18:2_0:0)(LPE(18:2))(OR:1.28,95CI:1.13-1.46,
P=1.42×10−4)
,Phosphatidylcholine
(PC)
(16:0_20:4)(OR:0.86,95CI:0.86-0.93,
P=1.38×10−4),Phosphatidylcholine
(18:0_20:3)(OR:1.29,95CI:1.12-1.47,
P=2.33×10−4)and
Phosphatidylcholine
(O-16:0_20:4)(OR:0.83,95CI:0.75-0.91,
P=2.22×10−4)showed
significant
relationships
aSAH.
Two
lipids,LPE
(18:2)(OR:1.22,95CI:1.11-1.34,
P=3.14×10−5)
PC
(16:1_18:2)(OR:1.19,95CI:1.09-1.31,
P=1.53×10−4)
exhibited
positive
correlation
risk
No
found
lipids.
Conclusion
Genetically
determined
(18:2)
,PC(18:0_20:3)
(16:1_18:2)
can
increase
rupture;while
PC(16:0_20:4)
(O-16:0_20:4)
reduce
rupture.PCs
arachidonic
acid
(AA)
chains
metabolism
AA
may
be
crucially
involved
occurrence
development
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Aug. 22, 2024
Intracranial
aneurysm
is
the
primary
cause
of
nontraumatic
subarachnoid
hemorrhage.
To
assess
metabolism,
we
present
a
method
intra-operatively
collecting
blood
samples
from
neck,
as
well
proximal
and
distal
responsible
vessels,
using
microcatheters.
Through
these
paired
comparisons,
can
eliminate
interpatient
variation
usually
observed
in
plasma
taken
peripheral
vein.
We
utilized
39
13
intracranial
patients
to
characterize
metabolite
profiles
untargeted
liquid
chromatography-mass
spectrometry.
Our
findings
revealed
that
l-tyrosine
upregulated
at
relatively
high
levels
neck
than
aneurysm,
whereas
phenylpyruvic
acid,
l-cystine,
l-ornithine
are
downregulated.
Based
on
this,
there
was
also
significant
decrease
arginine
within
small
internal
carotid
artery.
The
6-month
follow-up
indicated
who
experienced
good
recovery
had
lower
biliverdin,
bilirubin,
metabolites
coenzyme
Q
aneurysm.
In
conclusion,
our
investigation
provides
comprehensive
overview
with
aneurysms,
shedding
light
potential
pathogenetic
mechanisms
unruptured
aneurysms.
Moreover,
study
proposes
innovative
ideas
for
establishing
postoperative
timelines
flow
diverter
devices.
