Organic photoelectrochemical transistor biosensor for the detection of histone deacetylase Sirt1 based on the cleavage of deacetylated peptide chain by recombinant lysine endopeptidase DOI

Lanlan Gao,

Haowei Zhang, Yunlei Zhou

et al.

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 417, P. 136144 - 136144

Published: June 14, 2024

Language: Английский

Polyoxometalates: Cascading Functionality to Unique On‐Off Organic Photoelectrochemical Transistor Operation DOI
Feng‐Zao Chen,

Lu Hou,

Yuan Gao

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(48)

Published: June 29, 2024

Abstract While existing polyoxometalates (POMs) are predominantly utilized in a range of energy devices, their potential bioelectronics and optoelectronics, particularly organic photoelectrochemical transistors (OPECTs), remains unexplored. Here, the POMs this aspect is unveiled by POM/sulfide‐gated OPECT. The representative PW 12 /ZnIn 2 S 4 with cascading light‐harvesting enzyme‐like functionality enables unique on‐off OPECT operation. incorporation facilitates separation photogenerated charge carriers across heterojunction interface, consequently inducing pronounced gating effect. Linking CRISPR/Cas13a system correlating target miRNA‐21 biological generation H O , will enable polymerization dopamine into polydopamine thus sensitively inhibit gating. Experimental results demonstrated that developed sensor achieved good analytical performance detection limit as low 3.9 f m . This study demonstrates Given large family multifunction POMs, its implications diverse optoelectronics expected.

Language: Английский

Citations

30

Ag/AgCl‐Like Photogating of a COF‐on‐MOF Heterojunction in Organic Photoelectrochemical Transistor DOI
Zhen Wang, Xiaomei Shi, Feng‐Zao Chen

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(45)

Published: May 31, 2024

Abstract The pursuit of high on‐to‐off ratio ( I On / Off ), as one the important performances for organic electrochemical transistor (OECT) has been ongoing, but to date, limited solutions are available. interaction between light and matter demonstrated a rich source advanced electronic applications. However, its potential in modulation not fully explored. Herein, challenge is addressed through unique light‐material interplay, which represented by photoelectrochemical (OPECT) gated photosensitive COF‐LZU1 on mixed‐ligand MOF (COF‐on‐MOF) upon appropriate exposure illumination. Notably, interplay COF‐on‐MOF can adjust device physics, optimizing maximum enhancing signal transduction. Toward bio‐application, via exonuclease‐assisted cyclic cleavage amplification hybridization chain reaction, such validated highly sensitive detection capabilities human T‐cell lymphotropic virus type II (HTLV‐II) DNA down 0.003 fM. This study features possibility Ag/AgCl‐like photogating transistors light‐matter interplay.

Language: Английский

Citations

20

Organic photoelectrochemical memtransistor DOI Creative Commons
Zheng Li, Qingqing Wu,

M. Chen

et al.

eScience, Journal Year: 2025, Volume and Issue: unknown, P. 100374 - 100374

Published: Jan. 1, 2025

Language: Английский

Citations

8

MXene-Enhanced Bi2S3/CdIn2S4 Heterojunction Photosensitive Gate for DEHP Detection in a Signal-On OPECT Aptamer Biosensor DOI
Haowei Zhang,

Miao Zhang,

Zhengkun Yu

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(5), P. 1948 - 1956

Published: Jan. 24, 2024

Organic electrochemical transistors with signal amplification and good stability are expected to play a more important role in the detection of environmental pollutants. However, bias voltage at gate may have an effect on activity vulnerable biomolecules. In this work, novel organic photoelectrochemical transistor (OPECT) aptamer biosensor was developed for di(2-ethylhexyl) phthalate (DEHP) by combining analysis transistor, where MXene/Bi2S3/CdIn2S4 employed as photoactive material, target-dependent DNA hybridization chain reaction used unit, Ru(NH3)63+ selected enhancement molecule. The poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate)-based OPECT modulated photosensitive material achieved high current gain nearly thousand times zero voltage. signal-on sensing platform realized sensitive specific DEHP, range 1–200 pM minimum limit 0.24 under optimized experimental conditions, its application real water samples also evaluated satisfactory results. Hence, construction biosensing not only provides promising tool DEHP but reveals great potential other toxins.

Language: Английский

Citations

14

Metal-Organic Polymer Enables Efficient Organic Photoelectrochemical Transistor Biosensing DOI
Yuan Cheng, Qiqi Wu,

Ke-Xin Xu

et al.

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 257, P. 116346 - 116346

Published: April 27, 2024

Language: Английский

Citations

9

Applications and Prospects of Micro/nanoelectrodes in Single-cell Imaging and Electrochemical Detection DOI
Xiaoyang Zhang, Ke Huang, Xiangdong Lai

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118161 - 118161

Published: Jan. 1, 2025

Language: Английский

Citations

1

Iontronic Photoelectrochemical Biorecognition Probing DOI
Hang Dong, Haiyan Wang,

Yi‐Tong Xu

et al.

ACS Sensors, Journal Year: 2024, Volume and Issue: 9(2), P. 988 - 994

Published: Jan. 23, 2024

Herein, the first iontronic photoelectrochemical (PEC) biorecognition probing is devised by rational engineering of a dual-functional bioconjugate, i.e., light-sensitive intercalated structural DNA, as smart gating module confined within nanotip, which could respond to both incident light and biotargets interest. Light stimulation bioconjugate intensify negative charge at nano-orifice sustain enhanced ionic current. The presence proteins (e.g., acetylcholinesterase, AChE) or nucleic acids microRNA (miR)-10b) lead release with altered signaling. practical applicability methodology confirmed AChE detection in human serum miR-10b single cells.

Language: Английский

Citations

6

Bridging Ionic Current Rectification and Resistive-Pulse Sensing for Reliable Wide-Linearity Detection DOI
Xian Zhang, Zeng‐Qiang Wu,

You‐Wei Zheng

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(16), P. 6444 - 6449

Published: April 10, 2024

As two mainstream ionic detection techniques, current rectification (ICR) suffers from large fluctuations in trace level detection, while resistive-pulse sensing (RPS) encounters easy clogs high-concentration detection. By rationally matching the nanopore size with DNA tetrahedron (TDN), this work bridges techniques to achieve reliable wide linearity. a representative analyte, miRNA-10b could specifically combine and release TDN interior wall, which thus induced simultaneous generation of distinct ICR RPS signals. The signals be attributed balance between effective orifice surface charge density inner were by complex passing through nanopore. Such an operation contributed range 1 fM-1 nM good feasibility method is also validated single-cell real plasma

Language: Английский

Citations

5

Development of a Photoelectrochemical Microelectrode Using an Organic Probe for Monitoring Hydrogen Sulfide in Living Brains DOI
Yuanqiang Hao,

Yewen Yang,

Wenhui Wang

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(49), P. 19822 - 19832

Published: Nov. 22, 2024

Hydrogen sulfide (H2S) is an important bioactive molecule that plays a significant role in various functions, particularly the living brain, where it closely linked to cognition, memory, and several neurological diseases. Consequently, developing effective detection methods for H2S essential studying brain functions underlying mechanisms of these This study aims construct novel photoelectrochemical (PEC) microelectrode Ti/TiO2@HSP quantitative monitoring levels brain. The PEC formed by covalently bonding specifically designed organic probe HSP, which possesses D-π–A structure, surface TiO2 nanotubes generated via situ anodic oxidation titanium wire. HSP can effectively react with generate photocurrent response under long-wavelength excitation light (560 nm), thereby achieving H2S. sensor demonstrates high sensitivity good selectivity. In vivo experiments utilizing enable dynamic changes across regions mouse findings reveal normal mice, concentration hippocampus significantly higher than striatum cerebral cortex. Additionally, following propargylglycine drug stimulation, concentrations different were observed decrease, most substantial reduction noted hippocampus. suggests cystathionine γ-lyase (CSE) primary enzyme responsible production this area, while exhibits less pronounced decrease concentration, indicating reliance on alternative enzymatic pathways production. Therefore, not only successfully develops high-performance but also provides new experimental tools theoretical foundations further exploring roles neurophysiological pathological processes.

Language: Английский

Citations

5

Metal‐Organic Framework Nanozyme Enabling Dual‐Functional Photo‐Induced Charge Transfer and Biomimetic Precipitation for Advanced Organic Photoelectrochemical Transistor Bioanalysis DOI

Kexin Xu,

Yuan Cheng,

Hao Lou

et al.

Chinese Journal of Chemistry, Journal Year: 2024, Volume and Issue: 42(17), P. 1999 - 2004

Published: April 25, 2024

Comprehensive Summary We report herein the first observation of MOF nanozyme enabling dual‐functional photo‐induced charge transfer and biomimetic precipitation for advanced organic photoelectrochemical transistor (OPECT) bioanalysis. Specifically, Fe/Co‐MIL‐88, serving simultaneously as semiconductor nanozyme, was explored a gating module in OPECT. Upon light illumination, it could accelerate photogate to produce enhanced voltage. Meanwhile, its catalytic property efficiently block nanopores Fe/Co‐MIL‐88 thus alter device characteristics. The generic bioanalytical potential such rationale then demonstrated with an aptasensing assisted by magnetic separation. This work represents exploration from nanozymes OPECT bioanalysis, is expected attract more interest various novel optoelectronic bioanalytics.

Language: Английский

Citations

4