Environmental Science & Technology,
Journal Year:
2020,
Volume and Issue:
54(14), P. 8770 - 8778
Published: June 17, 2020
Antibiotic
resistance
is
one
of
the
most
challenging
issues
in
public
health.
Antibiotics
have
been
increasingly
used
not
only
for
humans
and
animals
but
also
crop
protection
as
pesticides.
Thus,
antibiotics
often
coexist
with
pesticides
some
environments.
To
investigate
effects
co-occurring,
nonantibiotic
on
development
antibiotic
resistance,
we
conducted
long-term
exposure
experiments
using
an
Escherichia
coli
K-12
model
strain.
The
results
reveal
that
(1)
to
(in
mg/L)
alone
led
emergence
mutants
significantly
higher
streptomycin;
(2)
μg/L)
together
a
subinhibitory
level
high
ampicillin
synergistically
stimulated
selection
cross-resistance
other
(i.e.,
ciprofloxacin,
chloramphenicol,
tetracycline).
Distinct
diversified
genetic
mutations
emerged
resistant
selected
from
coexposure
both
ampicillin.
likely
caused
holistic
transcriptional
regulation
(e.g.,
biofilm
formation,
oxidative
stress
defense)
when
grown
under
increased
resistance.
Together,
these
findings
provide
important
fundamental
insights
into
mechanisms
environmentally
relevant
conditions
where
micropollutants
coexist.
The Science of The Total Environment,
Journal Year:
2016,
Volume and Issue:
581-582, P. 909 - 922
Published: Dec. 24, 2016
When
chemical
or
microbial
contaminants
are
assessed
for
potential
effect
possible
regulation
in
ambient
and
drinking
waters,
a
critical
first
step
is
determining
if
the
occur
they
at
concentrations
that
may
cause
human
ecological
health
concerns.
To
this
end,
source
treated
water
samples
from
29
treatment
plants
(DWTPs)
were
analyzed
as
part
of
two-phase
study
to
determine
whether
constituents,
many
which
considered
emerging
concern,
detectable
waters.
Of
84
chemicals
monitored
9
Phase
I
DWTPs,
27
detected
least
once
water,
21
water.
In
II,
was
broader
more
comprehensive
assessment,
247
analytes
measured
25
with
148
121
The
frequency
detection
often
related
analyte's
contaminant
class,
pharmaceuticals
anthropogenic
waste
indicators
tended
be
infrequently
easily
removed
during
treatment,
while
per
polyfluoroalkyl
substances
inorganic
constituents
both
frequently
and,
overall,
resistant
treatment.
data
collected
project
will
used
help
inform
evaluation
unregulated
surface
groundwater,
The Science of The Total Environment,
Journal Year:
2015,
Volume and Issue:
540, P. 267 - 277
Published: July 11, 2015
Considerable
amounts
of
pharmaceuticals
are
used
in
human
and
veterinary
medicine,
which
not
efficiently
removed
during
wastewater
slurries
treatment
subsequently
entering
continuously
into
freshwater
systems.
The
intrinsic
biological
activity
these
non-regulated
pollutants
turns
their
presence
the
aquatic
environment
an
ecological
matter
concern.
We
present
first
quantitative
study
relating
predicted
ecotoxicological
effects
with
population
livestock
units.
Four
representative
Iberian
River
basins
(Spain)
were
studied:
Llobregat,
Ebro,
Júcar
Guadalquivir.
levels
determined
surface
water
sediment
samples
collected
from
77
locations
along
stream
networks.
Predicted
total
toxic
units
to
algae,
Daphnia
fish
estimated
for
detected
waters.
use
chemometrics
enabled
for:
spatial
distribution
rivers
two
consecutive
years;
potential
risk
organisms;
relationships
among
occurrence
ecotoxicity
animal
farming
pressure.
Llobregat
Ebro
characterized
as
most
polluted
at
highest
risk,
followed
by
No
significant
acute
risks
organisms
observed.
However
chronic
on
algae
could
be
expected
hot
spots
pollution
identified
basins.
Analgesics/antiinflammatories,
antibiotics
diuretics
relevant
therapeutic
groups
across
four
river
Among
them,
hydrochlorothiazide
gemfibrozil,
well
azithromycin
ibuprofen
widely
spread
concentrated
waters
sediments,
respectively.
Regarding
ecotoxicity,
sertraline,
gemfibrozil
loratidine
more
concerning
compounds.
Significantly
positive
found
density
both
matrices.
