Journal of Chromatography A, Journal Year: 2017, Volume and Issue: 1531, P. 64 - 73

Published: Nov. 13, 2017

A direct injection, multi residue analytical method separated in two chromatographic runs was developed utilizing scheduled analysis to simultaneously quantify 154 compounds, 84 precursors and 70 transformation products (TPs)/metabolites. Improvements the data quality, sensitivity reproducibility were achieved by scheduling of each analyte into pre-determined retention time windows. This study shows influence scan on dwell number points per peak as well effect precision analysis. Lowering decreased a minimal value, however, this had no negative effects precision. Increasing decreasing led more accurate shapes. final set parameters chosen obtain minimum 10 guarantee shapes thus validation performed for different water matrices yielding very good linearity all substances, with limits quantification mainly lower mid ng/L-range recoveries between 125% surface water, bank filtrate influents effluents wastewater treatment plants. The environmental samples revealed occurrence selected TPs analyzed matrices: 95% compounds target list could be quantified at least one sample. relevance metabolites such valsartan acid clopidogrel also confirmed their detection aqueous matrices. Wastewater indicators acesulfame diclofenac detected elevated concentrations substances oxipurinol which so far not focus monitoring programs. can used rapid various without any sample enrichment aid assessment quality processes.

Language: Английский