Biofilms: Novel Strategies Based on Antimicrobial Peptides

Pharmaceutics, Journal Year: 2019, Volume and Issue: 11(7), P. 322 - 322

Published: July 10, 2019

The problem of drug resistance is very worrying and ever increasing. Resistance due not only to the reckless use antibiotics but also fact that pathogens are able adapt different conditions develop self-defense mechanisms such as living in biofilms; altogether these issues make search for alternative drugs a real challenge. Antimicrobial peptides appear promising alternatives they have disadvantages do them easily applicable medical field; thus many researches look solutions overcome ensure advantages can be exploited. This review describes biofilm characteristics identifies key features antimicrobial should have. Recalcitrant bacterial infections caused by most obstinate species treated with strategy combine conventional functionalized nano-tools. approach could effectively disrupt high density biofilms. Moreover, importance using vivo non mammalian models studies described. In particular, here we analyze amphibians model substitute rodent model.

Language: Английский

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Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases

Clinical and Translational Allergy, Journal Year: 2019, Volume and Issue: 9(1)

Published: Sept. 9, 2019

Abstract Background In all societies, the burden and cost of allergic chronic respiratory diseases are increasing rapidly. Most economies struggling to deliver modern health care effectively. There is a need support transformation system into integrated with organizational literacy. Main body As an example for disease care, MASK (Mobile Airways Sentinel NetworK), new project ARIA (Allergic Rhinitis its Impact on Asthma) initiative, POLLAR (Impact Air POLLution Asthma Rhinitis, EIT Health), in collaboration professional patient organizations field allergy airway diseases, proposing real-life ICPs centred around rhinitis, using mHealth monitor environmental exposure. Three aspects pathways being developed: (i) Patient participation, literacy self-care through technology-assisted “patient activation”, (ii) Implementation by pharmacists (iii) Next-generation guidelines assessing recommendations GRADE rhinitis asthma real-world evidence (RWE) obtained mobile technology. The EU global political agendas great importance supporting digital has been recognized DG Santé as Good Practice digitally-enabled, integrated, person-centred care. Conclusion 20 years, considerably evolved from first multimorbidity guideline strong involvement.

Language: Английский

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Higher levels of greenness and biodiversity associate with greater subjective wellbeing in adults living in Melbourne, Australia

Health & Place, Journal Year: 2019, Volume and Issue: 57, P. 321 - 329

Published: May 1, 2019

Language: Английский

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Gene Transmission in the One Health Microbiosphere and the Channels of Antimicrobial Resistance

Frontiers in Microbiology, Journal Year: 2019, Volume and Issue: 10

Published: Dec. 16, 2019

Antibiotic resistance is a field in which the concept of One Health can best be illustrated. based on definition communication spaces among diverse environments. encoded by genes, however, these genes are propagated mobile genetic elements (MGEs), circulating bacterial species and clones that integrated into multiple microbiotas humans, animals, food, sewage, soil, water environments, microbiosphere. The dynamics evolution antibiotic depend networks linking all ecological, biological, entities. These communications occur environmental overlapping merging, critical issue countries with poor sanitation, but also favored homogenizing power globalization. overwhelming increase population highly uniform food animals has contributed to parallel absolute size their microbiotas, consequently enhancing possibility microbiome merging between humans animals. Microbial communities coalescence might lead shared microbiomes spread (of human, animal, or origin) facilitated. Intermicrobiome exerted shuttle (or within species) belonging generalist taxa, able multiply various hosts, including plants. Their integration local exchange fosters gene flow, following channels accessory genome species. delineate topology circulation, dense clusters frequent historical recent exchanges. ecological compatibility species, sharing same niches determines possibilities. In summary, fertility approach depends progress understanding multihierarchical systems, encompassing environments (macro/microaggregates), (communities), (clones), MGEs.

Language: Английский

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Antibiotic resistance in the environment: a critical insight on its occurrence, fate, and eco-toxicity

Environmental Science and Pollution Research, Journal Year: 2021, Volume and Issue: 28(20), P. 24889 - 24916

Published: March 25, 2021

Language: Английский

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