Analysis of Microplastics in Human Feces Reveals a Correlation between Fecal Microplastics and Inflammatory Bowel Disease Status

Environmental Science & Technology, Journal Year: 2021, Volume and Issue: 56(1), P. 414 - 421

Published: Dec. 22, 2021

Human ingestion of microplastics (MPs) is inevitable due to the ubiquity MPs in various foods and drinking water. Whether poses a substantial risk human health far from understood. Here, by analyzing characteristics feces patients with inflammatory bowel disease (IBD) healthy people, for first time, we found that fecal MP concentration IBD (41.8 items/g dm) was significantly higher than people (28.0 dm). In total, 15 types were detected feces, poly(ethylene terephthalate) (22.3–34.0%) polyamide (8.9–12.4%) being dominant, their primary shapes sheets fibers, respectively. We present evidence indicating positive correlation exists between severity IBD. Combining questionnaire survey MPs, conclude plastic packaging water food dust exposure are important sources MPs. Furthermore, status suggests may be related process or exacerbates retention The relative mechanisms deserve further studies. Our results also highlight useful assessing potential risks.

Language: Английский

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Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature

Particle and Fibre Toxicology, Journal Year: 2020, Volume and Issue: 17(1)

Published: Nov. 12, 2020

Abstract Background Together with poor biodegradability and insufficient recycling, the massive production use of plastics have led to widespread environmental contamination by nano- microplastics. These particles accumulate across ecosystems - even in most remote habitats are transferred through food chains, leading inevitable human ingestion, that adds highest one due processes packaging. Objective The present review aimed at providing a comprehensive overview current knowledge regarding effects microplastics on intestinal homeostasis. Methods We conducted literature search focused vivo gut epithelium microbiota, as well immune response. Results Numerous animal studies shown exposure leads impairments oxidative inflammatory balance, disruption gut’s epithelial permeability. Other notable microplastic include dysbiosis (changes microbiota) cell toxicity. Moreover, contain additives, adsorb contaminants, may promote growth bacterial pathogens their surfaces: they potential carriers toxicants can potentially lead further adverse effects. Conclusion Despite scarcity reports directly relevant human, this brings together growing body evidence showing disturbs microbiota critical functions. Such development chronic disorders. Further investigation threat health is warranted.

Language: Английский

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Uptake and effects of orally ingested polystyrene microplastic particles in vitro and in vivo

Archives of Toxicology, Journal Year: 2019, Volume and Issue: 93(7), P. 1817 - 1833

Published: May 28, 2019

Language: Английский

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Environmental fate and impacts of microplastics in soil ecosystems: Progress and perspective

The Science of The Total Environment, Journal Year: 2019, Volume and Issue: 708, P. 134841 - 134841

Published: Nov. 14, 2019

Language: Английский

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Exposure to polystyrene microplastics causes reproductive toxicity through oxidative stress and activation of the p38 MAPK signaling pathway

Ecotoxicology and Environmental Safety, Journal Year: 2019, Volume and Issue: 190, P. 110133 - 110133

Published: Dec. 30, 2019

Language: Английский

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Micro- and nanoplastic toxicity on aquatic life: Determining factors

The Science of The Total Environment, Journal Year: 2019, Volume and Issue: 709, P. 136050 - 136050

Published: Dec. 19, 2019

Plastic pollution has become a major environmental concern due to its omnipresence and degradation smaller particles. The potential toxicological effects of micro- nanoplastic on biota have been investigated in growing number exposure studies. We performed comprehensive review the main determining factors for plastic particle toxicity relevant systems, from publications until including year 2018. For focused scope, additives or other pollutants accumulated by particles are not included. In summary, current literature suggests that depends concentration, size, time, condition, shape polymer type. Furthermore, contaminant background, food availability, species, developmental stage sex influence outcome exposures. Frequently reported were body population growth, energy metabolism, feeding, movement activity, physiological stress, oxidative inflammation, immune system, hormonal regulation, aberrant development, cell death, general altered lipid metabolism. Several times increased growth consumption, neuro-, liver- kidney pathology intestinal damage. Photosynthesis disruption was studies investigating phytoplankton. currently unquantified below 10 μm, more toxic all aquatic life, as compared larger size.

Language: Английский

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Microplastic release from the degradation of polypropylene feeding bottles during infant formula preparation

Nature Food, Journal Year: 2020, Volume and Issue: 1(11), P. 746 - 754

Published: Oct. 19, 2020

Language: Английский

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Microplastics and environmental pollutants: Key interaction and toxicology in aquatic and soil environments

Journal of Hazardous Materials, Journal Year: 2021, Volume and Issue: 422, P. 126843 - 126843

Published: Aug. 8, 2021

Language: Английский

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Micro- and nano-plastics activation of oxidative and inflammatory adverse outcome pathways

Redox Biology, Journal Year: 2020, Volume and Issue: 37, P. 101620 - 101620

Published: July 17, 2020

Microplastics (MPs) and nanoplastics (NPs) have attracted considerable attention in the recent years as potential threats to ecosystem public health. This review summarizes current knowledge of pathological events triggered by micro- nano-plastics (MP/NPs) with focus on oxidative damages at different levels biological complexity (molecular, cellular, tissue, organ, individual population). Based published information, we matched apical toxicity endpoints induced MP/NPs key event (KE) or adverse outcomes (AO) categorized them according Adverse Outcome Pathway (AOP) online knowledgebase. We used existing AOPs applied highlight formal mechanistic links between identified KEs AOs two possible scenarios: first from ecological, second health perspective. Ecological perspective AOP based literature analysis revealed that share formation reactive oxygen species their molecular initiating event, leading such growth inhibition behavior alteration through stress cascades inflammatory responses. Application data related showed its responding pathways, including responses, could play role events. However insufficient information prevented precise definitions this level. To overcome gap, further mammalian model epidemiological studies are necessary support development construction detailed focus.

Language: Английский

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Effects of polystyrene microplastics on the composition of the microbiome and metabolism in larval zebrafish

Chemosphere, Journal Year: 2018, Volume and Issue: 217, P. 646 - 658

Published: Nov. 12, 2018

Language: Английский

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