A systematic review for non-targeted analysis of per- and polyfluoroalkyl substances (PFAS)

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 960, P. 178240 - 178240

Published: Jan. 1, 2025

This review follows the PRISMA guidelines to provide a systematic of 115 peer reviewed articles that used non-targeted analysis (NTA) methods detect per- and polyfluoroalkylated substances (PFAS). literature highlights significant positive impact NTA in understanding PFAS environment. Within geographical bias exists, with most studies (∼60 %) conducted United States China. Future other regions (such as South America Africa) are needed gain more global understanding. More research is required marine environments atmosphere, current focus mainly on freshwater, groundwater, soil, sediments. The majority measuring environment, rather than commercial products (with exception AFFF). Non-lethal blood sampling has been successful for humans wildlife, but additional biomonitoring exposed cohorts understand health risks biotransformation pathways. mostly use liquid chromatography negative ionisation, which biases towards detection specific PFAS. Despite improvements data reporting quality assurance control (QA/QC) procedures, factors such false rates often overlooked, many workflows remain highly subjective. Perfluoroalkyl carboxylic acids (PFCAs) perfluoroalkyl sulfonic (PFSAs) detected classes, identified over 80 % studies, common routine monitoring. However, our >1000 from total 382 different 300 classes found fewer 5 studies. variety present limitations relying solely targeted methods. monitoring programs regulations would benefit considering comprehensive information

Language: Английский

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Non-Invasive Matrices for the Human Biomonitoring of PFAS: An Updated Review of the Scientific Literature

Toxics, Journal Year: 2025, Volume and Issue: 13(2), P. 134 - 134

Published: Feb. 12, 2025

Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals widely used in consumer industrial products due to their unique physicochemical properties. However, persistence bioaccumulative potential pose significant environmental human health risks. This review focuses on the use of non-invasive matrices-urine, hair, nails-for biomonitoring PFAS, highlighting key findings from scientific studies. While urine offers a practical option, its limited sensitivity for long-chain PFAS requires further analytical advances. Hair nails have demonstrated biomonitoring, with higher detection frequencies concentrations certain compared urine. The variability levels across studies reflects differences population characteristics, exposure sources, geographic regions. emphasizes need standardized methods, expanded studies, complementary matrices enhance accuracy reliability assessment.

Language: Английский

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PFC/PFAS concentrations in human milk and infant exposure through lactation: a comprehensive review of the scientific literature

Archives of Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 22, 2025

Abstract Per- and polyfluoroalkyl substances (PFAS), previously known as perfluorinated compounds (PFC), are a group of synthetic chemicals widely used over the past decades. Their extensive application, combined with their environmental persistence, has contributed to ubiquitous presence in environment associated toxicological risks. Regarding humans, blood serum testing remains primary method for biomonitoring PFAS exposure, while breast milk also been due transfer these from mothers infants during lactation. This paper aims review scientific literature (using PubMed Scopus databases) on concentrations non-occupationally exposed women. Where available, estimated daily intake by breastfeeding is examined. The reviewed studies categorized continent country/region, revealing significant lack data many countries, including both developed developing nations. findings indicate substantial variability concentrations, influenced factors such geographic location, sampling year, specific analyzed. Among identified compounds, perfluorooctane sulfonate (PFOS) perfluorooctanoic acid (PFOA) most commonly detected, along perfluorohexanesulfonic (PFHxS) perfluorononanoic (PFNA), being only regulated maximum levels certain foodstuffs. Most were conducted before implementation current (updated) tolerable weekly (TWI) values substances. Consequently, majority reported low health risk infants, even high-intake scenarios. Nevertheless, urgently needed countries limited or no data, new investigations should assess whether intakes exceed updated TWI. Special focus be given rural industrial areas where exposure remain poorly understood.

Language: Английский

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Deriving Membrane–Water and Protein–Water Partition Coefficients from In Vitro Experiments for Per- and Polyfluoroalkyl Substances (PFAS)

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

The phospholipid membrane-water partition coefficients (

Language: Английский

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Legacy and Emerging Poly and Perfluoroalkyl Substances (PFAS) in Surface Water, Sediments, and Treated Effluent: A Case Study in Pretoria (South Africa)

Water Air & Soil Pollution, Journal Year: 2025, Volume and Issue: 236(5)

Published: April 11, 2025

Language: Английский

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