Rescue of SARS-CoV-2 from a Single Bacterial Artificial Chromosome DOI Creative Commons
Chengjin Ye, Kevin Chiem, Jun‐Gyu Park

et al.

mBio, Journal Year: 2020, Volume and Issue: 11(5)

Published: Sept. 28, 2020

The pandemic coronavirus (CoV) disease 2019 (COVID-19) caused by severe acute respiratory syndrome CoV-2 (SARS-CoV-2) is a major threat to global human health. To date, there are no approved prophylactics or therapeutics available for COVID-19. Reverse genetics powerful approach understand factors involved in viral pathogenesis, antiviral screening, and vaccine development. In this study, we describe the feasibility of generating recombinant SARS-CoV-2 (rSARS-CoV-2) transfection single bacterial artificial chromosome (BAC). Importantly, rSARS-CoV-2 possesses same phenotype as natural isolate vitro vivo . This first description BAC-based reverse system time that an has been shown be phenotypically identical validated animal model infection. will facilitate study development treatment

Language: Английский

Pharmacokinetic, Pharmacodynamic, and Drug-Interaction Profile of Remdesivir, a SARS-CoV-2 Replication Inhibitor DOI Creative Commons
Rita Humeniuk,

Anita Mathias,

Brian J. Kirby

et al.

Clinical Pharmacokinetics, Journal Year: 2021, Volume and Issue: 60(5), P. 569 - 583

Published: March 30, 2021

Remdesivir (RDV, Veklury

Citations

113
Electronic textiles: New age of wearable technology for healthcare and fitness solutions DOI Creative Commons
Jagan Singh Meena,

Su Bin Choi,

Seung‐Boo Jung

et al.

Materials Today Bio, Journal Year: 2023, Volume and Issue: 19, P. 100565 - 100565

Published: Jan. 28, 2023

Sedentary lifestyles and evolving work environments have created challenges for global health cause huge burdens on healthcare fitness systems. Physical immobility functional losses due to aging are two main reasons noncommunicable disease mortality. Smart electronic textiles (e-textiles) attracted considerable attention because of their potential uses in monitoring, rehabilitation, training assessment applications. Interactive integrated with devices algorithms can be used gather, process, digitize data human body motion real time purposes such as electrotherapy, improving blood circulation, promoting wound healing. This review summarizes research advances e-textiles designed wearable The significance e-textiles, key applications, future demand expectations addressed this review. Various conditions problems possible solutions involving the use multifunctional interactive garments discussed. A brief discussion essential materials basic procedures fabricate included. Finally, current challenges, solutions, opportunities, perspectives area smart

Language: Английский

Citations

113
Potential therapeutic targets for combating SARS-CoV-2: Drug repurposing, clinical trials and recent advancements DOI Open Access

Abhjieet Pandey,

Ajinkya Nitin Nikam, Ajjappla Basavaraj Shreya

et al.

Life Sciences, Journal Year: 2020, Volume and Issue: 256, P. 117883 - 117883

Published: June 1, 2020

Language: Английский

Citations

131
Psychological Impact of COVID-19 Emergency on Health Professionals: Burnout Incidence at the Most Critical Period in Spain DOI Open Access
José Ángel Martínez López, Cristina Lázaro-Pérez, José Gómez Galán

et al.

Journal of Clinical Medicine, Journal Year: 2020, Volume and Issue: 9(9), P. 3029 - 3029

Published: Sept. 20, 2020

Background: The health profession is a burnout producer due to the continuous contact with pain and suffering. In addition, excessive workloads can generate stress psychological distress. Objectives: aim of this study was determine degree its main triggers in professionals Spain at most critical period COVID-19 emergency. Method: A quantitative research developed through simple random sampling different Spanish hospitals greatest impact pandemic (N = 157). Data were collected using standardized questionnaire from Maslach inventory (MBI) containing 22 items, which measures three subscales: emotional burnout, depersonalization, self-fulfillment. Results: depersonalization values reached 38.9%. total 90.4% considered that care should be provided work centers. Furthermore, 43.3% estimated they might need treatment future. Finally, 85.4% stated lack personal protective equipment (PPE) generated an increase anxiety. Conclusion: This demonstrates consider specific mental services training crises avoid possible disorders. information obtained also valuable for development future prevention protocols personnel face pandemics these characteristics or emergency scenarios. Having necessary physical means their protection, as well updated regular accurate information, essential feelings fear uncertainty. would promote professionals.

Language: Английский

Citations

127
Rescue of SARS-CoV-2 from a Single Bacterial Artificial Chromosome DOI Creative Commons
Chengjin Ye, Kevin Chiem, Jun‐Gyu Park

et al.

mBio, Journal Year: 2020, Volume and Issue: 11(5)

Published: Sept. 28, 2020

The pandemic coronavirus (CoV) disease 2019 (COVID-19) caused by severe acute respiratory syndrome CoV-2 (SARS-CoV-2) is a major threat to global human health. To date, there are no approved prophylactics or therapeutics available for COVID-19. Reverse genetics powerful approach understand factors involved in viral pathogenesis, antiviral screening, and vaccine development. In this study, we describe the feasibility of generating recombinant SARS-CoV-2 (rSARS-CoV-2) transfection single bacterial artificial chromosome (BAC). Importantly, rSARS-CoV-2 possesses same phenotype as natural isolate vitro vivo . This first description BAC-based reverse system time that an has been shown be phenotypically identical validated animal model infection. will facilitate study development treatment

Language: Английский

Citations

120