Is the lockdown important to prevent the COVID-19 pandemic? Effects on psychology, environment and economy-perspective

Annals of Medicine and Surgery, Journal Year: 2020, Volume and Issue: 56, P. 38 - 42

Published: June 14, 2020

COVID-19's daily increasing cases and deaths have led to worldwide lockdown, quarantine some restrictions. This study aims analyze the effect of lockdown days on spread coronavirus in countries. COVID-19 data were collected for 49 countries that implemented between certain dates (without interruption). The correlation tests used analysis based unconstrained (normal) constrained (Tukey-lambda). was significantly correlated with pandemic (r = −0.9126, F-ratio 6.1654; t-ratio 2.40; prob > .0203 observations) Tukey-lambda 0.7402, λ 0.14). one social isolation restrictions, has been observed prevent pandemic, showed virus can be reduced by this preventive restriction study. offers initial evidence suppressed a lockdown. application governments is also thought effective psychology, environment economy besides having impact Covid-19.

Language: Английский

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Impact of COVID-19 on the social, economic, environmental and energy domains: Lessons learnt from a global pandemic

Sustainable Production and Consumption, Journal Year: 2020, Volume and Issue: 26, P. 343 - 359

Published: Oct. 14, 2020

Language: Английский

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Exploring the impact of COVID-19 on tourism: transformational potential and implications for a sustainable recovery of the travel and leisure industry

Current Research in Behavioral Sciences, Journal Year: 2021, Volume and Issue: 2, P. 100033 - 100033

Published: April 21, 2021

The study stipulates phases to observe the proposed mechanism in formulating travel and leisure industry's recovery strategies. present pandemic COVID-19 has resulted global challenges, economic healthcare crises, posed spillover impacts on industries, including tourism that major contributor service industry worldwide. faced hardest-hit lies among most damaged industries. internal indicated a steep decline amounting 2.86 trillion US dollars, which quantified more than 50% revenue losses. In first step, explores consequences settings of how innovation change can contribute revival next normal. Thus, determines enterprises scholars must consider basic principles, main assumptions, organizational situations related research practice framework through rebuilding establishing sector. second discusses direct impacts, attitudes, practices gaining boom recovery. third phase, proposes characteristics research. findings provide insights regaining operational activities offer helpful suggestions government officials, scholars, firms reinvest set it back normal position.

Language: Английский

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Prediction and analysis of COVID-19 positive cases using deep learning models: A descriptive case study of India

Chaos Solitons & Fractals, Journal Year: 2020, Volume and Issue: 139, P. 110017 - 110017

Published: June 17, 2020

Language: Английский

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Meat consumption: Which are the current global risks? A review of recent (2010–2020) evidences

Food Research International, Journal Year: 2020, Volume and Issue: 137, P. 109341 - 109341

Published: May 29, 2020

Language: Английский

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COVID-19: Characteristics and Therapeutics

Cells, Journal Year: 2021, Volume and Issue: 10(2), P. 206 - 206

Published: Jan. 21, 2021

Novel coronavirus (COVID-19 or 2019-nCoV SARS-CoV-2), which suddenly emerged in December 2019 is still haunting the entire human race and has affected not only healthcare system but also global socioeconomic balances. COVID-19 was quickly designated as a pandemic by World Health Organization there have been about 98.0 million confirmed cases 2.0 deaths, of January 2021. Although, our understanding significantly increased since its outbreak, multiple treatment approaches pharmacological interventions tested are currently under development to mitigate risk-factors. Recently, some vaccine candidates showed around 95% clinical efficacy, now receiving emergency use approvals different countries. US FDA recently approved BNT162 mRNA-1273 vaccines developed Pfizer/BioNTech Moderna Inc. for vaccination USA. In this review, we present succinct overview SARS-CoV-2 virus structure, molecular mechanisms infection, epidemiology, diagnosis, manifestations. We systematize strategies trials initiated after based on viral infection replication mechanisms. Additionally, reviewed novel intervention against COVID-19. speculate that current will trigger detailed studies coronaviruses, their mechanism systematic drug repurposing approaches, discoveries future outbreaks.

Language: Английский

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SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species

Emerging Microbes & Infections, Journal Year: 2020, Volume and Issue: 10(1), P. 178 - 195

Published: Dec. 29, 2020

The genome of SARS-CoV-2 encodes two viral proteases (NSP3/papain-like protease and NSP5/3C-like protease) that are responsible for cleaving polyproteins during replication. Here, we discovered new functions the NSP3 NSP5 SARS-CoV-2, demonstrating they could directly cleave proteins involved in host innate immune response. We identified 3 were specifically selectively cleaved by or NSP5: IRF-3, NLRP12 TAB1, respectively. Direct cleavage IRF3 explain blunted Type-I IFN response seen infections while mediated TAB1 point to a molecular mechanism enhanced production cytokines inflammatory responThe observed COVID-19 patients. demonstrate mouse protein, one recognition site is not our in-vitro assay. pushed this comparative alignment IRF-3 homologs show lack presence cognate motifs contribute presentation disease cats tigers, example. Our findings provide an explanatory framework indepth studies into pathophysiology COVID-19.

Language: Английский

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Antibacterial and Antiviral Functional Materials: Chemistry and Biological Activity toward Tackling COVID-19-like Pandemics

ACS Pharmacology & Translational Science, Journal Year: 2020, Volume and Issue: 4(1), P. 8 - 54

Published: Dec. 29, 2020

The ongoing worldwide pandemic due to COVID-19 has created awareness toward ensuring best practices avoid the spread of microorganisms. In this regard, research on creating a surface which destroys or inhibits adherence microbial/viral entities gained renewed interest. Although many reports are available antibacterial materials coatings, there is relatively small amount data use antiviral materials. However, with more geared area, new information being added literature every day. combination and chemical represents potentially path-breaking intervention mitigate disease-causing agents. review, we have surveyed various classes such as small-molecule organics, synthetic biodegradable polymers, silver, TiO2, copper-derived chemicals. protection mechanisms against pathogen colonies discussed in detail, highlights key differences that could determine parameters would govern future development advanced surfaces.

Language: Английский

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SARS-CoV-2-Specific Immune Response and the Pathogenesis of COVID-19

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(3), P. 1716 - 1716

Published: Feb. 2, 2022

The review aims to consolidate research findings on the molecular mechanisms and virulence pathogenicity characteristics of coronavirus disease (COVID-19) causative agent, severe acute respiratory syndrome 2 (SARS-CoV-2), their relevance four typical stages in development viral infection. These are invasion; primary blockade antiviral innate immunity; engagement virus’s protection against factors adaptive acute, long-term complications COVID-19. invasion stage entails recognition spike protein (S) SARS-CoV-2 target cell receptors, namely, main receptor (angiotensin-converting enzyme 2, ACE2), its coreceptors, potential alternative receptors. presence a diverse repertoire receptors allows infect various types cells, including those not expressing ACE2. During second stage, majority polyfunctional structural, non-structural, extra proteins synthesizes infected cells involved blockage immunity. A high degree redundancy systemic action characterizing these pathogenic overcome at initial invasion. third includes passive active virus from immunity, overcoming barrier function focus inflammation, generalization body. fourth is associated with deployment variants SARS-CoV-2’s ability induce autoimmune autoinflammatory pathways tissue both immunosuppressive hyperergic inflammation critical this

Language: Английский

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Impact of COVID-19 pandemic on mobility in ten countries and associated perceived risk for all transport modes

PLoS ONE, Journal Year: 2021, Volume and Issue: 16(2), P. e0245886 - e0245886

Published: Feb. 1, 2021

The restrictive measures implemented in response to the COVID-19 pandemic have triggered sudden massive changes travel behaviors of people all around world. This study examines individual mobility patterns for transport modes (walk, bicycle, motorcycle, car driven alone, company, bus, subway, tram, train, airplane) before and during restrictions adopted ten countries on six continents: Australia, Brazil, China, Ghana, India, Iran, Italy, Norway, South Africa United States. cross-country also aims at understanding predictors protective related sector COVID-19. Findings hinge upon an online survey conducted May 2020 (N = 9,394). empirical results quantify tremendous disruptions both commuting non-commuting travels, highlighting substantial reductions frequency types trips use modes. In terms potential virus spread, airplanes buses are perceived be riskiest modes, while avoidance public is consistently found across countries. According Protection Motivation Theory, sheds new light fact that two indicators, namely income inequality, expressed as Gini index, reported number deaths due per 100,000 inhabitants, aggravate respondents' perceptions. research indicates socio-economic inequality morbidity not only actual health risks, well documented relevant literature, but risks. These findings document global impact crisis provide guidance transportation practitioners developing future strategies.

Language: Английский

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