Adverse effects of exposure to fine particles and ultrafine particles in the environment on different organs of organisms

Journal of Environmental Sciences, Journal Year: 2022, Volume and Issue: 135, P. 449 - 473

Published: Aug. 19, 2022

Language: Английский

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Radon Exposure and Gestational Diabetes

JAMA Network Open, Journal Year: 2025, Volume and Issue: 8(1), P. e2454319 - e2454319

Published: Jan. 10, 2025

Importance Understanding environmental risk factors for gestational diabetes (GD) is crucial developing preventive strategies and improving pregnancy outcomes. Objective To examine the association of county-level radon exposure with GD in pregnant individuals. Design, Setting, Participants This multicenter, population-based cohort study used data from Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be (nuMoM2b) cohort, which recruited nulliparous participants 8 US clinical centers between October 2010 September 2013. who had pregestational or were missing on measurements excluded current study. Data analyzed 2023 to January 2024. Exposures County-level created by Lawrence Berkeley National Laboratory based Environmental Protection Agency’s short- long-term indoor home assessments. Radon was categorized into 3 groups: less than 1, 1 2, 2 more picocuries (pCi)/L (to convert becquerels per cubic meter, multiply 37). Because radon, smoking, fine particulate matter air pollutants (PM 2.5 ) may share similar biological pathways, joint classifications level (<2 ≥2 pCi/L) smoking status (never smokers ever smokers) PM (above below median). Main Measures The main outcome GD, identified glucose tolerance testing information medical record abstraction. Multiple logistic regression models assess GD. Results Among 9107 participants, mean (SD) age 27.0 (5.6) years; 3782 9101 (41.6%) tobacco. concentration 1.6 (0.9) pCi/L, 382 (4.2%) recorded. After adjusting potential confounders, individuals living counties highest (≥2 higher odds compared those lowest (<1 (odds ratio [OR], 1.37; 95% CI, 1.02-1.84); after additional adjustment , OR 1.36 (95% 1.00-1.86). Elevated also observed a (OR, 2.09; 1.41-3.11) levels 1.93; 1.31-2.83), though no statistically significant interactions observed. Conclusions Relevance suggests that associated greater Further studies are needed confirm results elucidate underlying mechanisms, especially individual-level residential assessment.

Language: Английский

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Association of air pollution and fine particulate matter (PM2.5) exposure with gestational diabetes: a systematic review and meta-analysis

Annals of Translational Medicine, Journal Year: 2023, Volume and Issue: 11(1), P. 23 - 23

Published: Jan. 1, 2023

The association between air pollution (AP) and gestational diabetes mellitus (GDM), especially different pollutants GDM, remains controversial debatable. Hence, we conducted this systematic review meta-analysis to provide comprehensive evidence-based support for the AP GDM.The databases of Cochrane Library, Embase, PubMed, Web Science were searched from inception 1 April 2022, in combination with manual retrieval. Newcastle-Ottawa Scale (NOS) was used assess quality case-control studies cohort studies, while Joana Brigg's Institute (JBI) critical appraisal checklist assessment cross-sectional studies.We identified 35 epidemiological (including 33 study, study) covering 6,939,725 pregnant women, whom 865,460 GDM patients. NOS score all included higher than six, one rated as high according JBI assessment. Meta-analysis showed that fine particulate matter [PM2.5, odds ratio (OR) =1.06, 95% confidence interval (CI): 1.05-1.08, Z =7.76, P<0.001; PM10, OR CI: 1.01-1.11, =2.62, P=0.009; sulfur dioxide (SO2), =1.18, 1.10-1.26, = 4.69, nitric oxide (NO), =1.04, 1.03-1.06,Z =3.33, P=0.001; nitrogen oxides (NOX), =1.07, 1.04-1.11, =3.93, black carbon (BC), =1.08, 1.06-1.10, =7.58, P<0.001] associated GDM. Furthermore, no significant observed O3, CO, (NO2) exposure GDM.Exposure PM2.5, SO2, NO, NOX, BC significantly increases risk is a remediable environmental trigger can be prevented by human interventions, such lowering levels or limiting pollutants. government should strengthen supervision make information more transparent. Besides, living conditions are crucial during pregnancy. Living place green areas recommended, indoor purification also enhanced.

Language: Английский

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Assessment of Environmental Risk Factors for Gestational Diabetes Mellitus: A Ten-Year Systematic Review and Meta-Analysis

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(5), P. 1646 - 1646

Published: Feb. 28, 2025

Background/Objectives: It is estimated that gestational diabetes mellitus (GDM) affects approximately 14% of pregnant women. This due to the inability body produce enough insulin for gestation. With greater appearance during second and third trimesters, GDM has a multifactorial cause including hypertension, cardiovascular issues (CVD), family history both or either type two (T2DM) GDM, obesity, advanced maternal age, polycystic ovarian syndrome (PCOS). However, it been suggested except genetic predisposition, environmental factors can increase risk development great extent. The aim this systematic review meta-analysis examination different contributors play significant role in GDM. Methods: databases used were PubMed ScienceDirect. inclusion criteria 10-year duration (2014–2024), English language, research articles, only humans included. Afterwards, tables created summarize most important information from each article. Forest funnel plots assess possibility greatly difference between contributor. Results: Initially, 9361 articles found. After automation tools applied, 706 left. total number study after screening process was 26. Through analysis, following stated contributing with GDM: extreme temperatures (both high low), organophosphorus flame retardants (OFRs), bisphenol A (BPA), selenium (Se), metallic elements, urinary antimony (Sb), trace thiamine riboflavin, fine particulate matter PM2.5. Conclusions: meta-analysis, be concluded there statistical significance PM2.5, especially first (p < 0.001) proving acknowledged connection PM2.5 pathogenesis pregnancy. Apart that, fetal sex an as greatest males 0.001), whereas no correlation smoking habit In conclusion, have impact on period, but more studies must carried out reinforce our outcomes.

Language: Английский

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Residential radon exposure and hypertensive disorders of pregnancy in Massachusetts, USA: A cohort study

Environment International, Journal Year: 2020, Volume and Issue: 146, P. 106285 - 106285

Published: Dec. 8, 2020

Exposure to ionizing radiation has been associated with hypertension, but the relationship between residential radon exposure and hypertensive disorders of pregnancy (HDP) not examined.We used Massachusetts Birth Registry Vital Records from 2001 2015 including women a singleton without prior hypertension. The binary outcome included gestational hypertension pre-eclampsia cases was assessed using birth certificate data. We obtained 141,665 basement measurements Spruce Environmental Technologies, Inc. modeled monthly zip code level. logistic regression model adjusted for sociodemographic covariates, maternal comorbidities, PM2.5, season, temperature, relative humidity. examined effect modification by age, race, education as an indicator socio-economic status.Of 975,528 women, 3.7% (36,530) them developed HDP. Zip level ranged 22 333 mBq/m3. An interquartile range (IQR) increase in throughout 15% odds HDP (95% CI 13% 18%). In less than 20 years old, IQR 38% 24% 50%), while smaller older women. There no race or education.In this cohort, higher levels are increased After stratifying stronger participants younger old. Since burden is increasing affects women's future cardiovascular health, identification modifiable risk factors great importance.

Language: Английский

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Status and frontier analysis of indoor PM_2.5-related health effects: a bibliometric analysis

Reviews on Environmental Health, Journal Year: 2023, Volume and Issue: 39(3), P. 479 - 498

Published: March 28, 2023

Abstract Epidemiological data indicate atmospheric particulate matter, especially fine matter (PM 2.5 ), has many negative effects on human health. Of note, people spend about 90% of their time indoors. More importantly, according to the World Health Organization (WHO) statistics, indoor air pollution causes nearly 1.6 million deaths each year, and it is considered as one major health risk factors. In order obtain a deeper understanding harmful PM health, we used bibliometric software summarize articles in this field. conclusion, since 2000, annual publication volume increased year by year. America topped list for number articles, Professor Petros Koutrakis Harvard University were author institution with most published research area, respectively. Over past decade, scholars gradually paid attention molecular mechanisms, therefore, toxicity can be better explored. Particularly, apart from timely intervention treatment adverse consequences, necessary effectively reduce through technologies. addition, trend keywords analysis are favorable ways find out future hotspots. Hopefully, various countries regions strengthen academic cooperation integration multi-disciplinary.

Language: Английский

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Nicotinamide mononucleotide ameliorates ionizing radiation-induced spermatogenic dysfunction in mice by modulating the glycolytic pathway

Acta Biochimica et Biophysica Sinica, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 13, 2024

Radiotherapy, a common cancer treatment, leads to infertility in male survivors, particularly young and middle-aged patients. Nicotinamide mononucleotide (NMN), precursor of nicotinamide adenine dinucleotide (NAD

Language: Английский

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Exposure to Radon and Ambient Particle Radioactivity During Pregnancy and Adverse Maternal, Fetal and Perinatal Outcomes: The Current Literature and Potential Mechanisms

Environmental Research, Journal Year: 2024, Volume and Issue: unknown, P. 120272 - 120272

Published: Oct. 1, 2024

Language: Английский

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Consequences of the exposome to gestational diabetes mellitus

Biochimica et Biophysica Acta (BBA) - General Subjects, Journal Year: 2022, Volume and Issue: 1867(2), P. 130282 - 130282

Published: Nov. 25, 2022

Language: Английский

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Prenatal exposure to ambient particle radioactivity and fetal growth in Eastern Massachusetts

Air Quality Atmosphere & Health, Journal Year: 2023, Volume and Issue: 16(4), P. 805 - 815

Published: Jan. 27, 2023

Language: Английский

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