Organophosphate esters in soils of Beijing urban parks: Occurrence, potential sources, and probabilistic health risks DOI
Y.X. Tian,

Y. Wang,

H.Y. Chen

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 879, P. 162855 - 162855

Published: March 15, 2023

Language: Английский

Spatiotemporal transitions of organophosphate esters (OPEs) and brominated flame retardants (BFRs) in sediments from the Pearl River Delta, China DOI
Zhilang Lao, Huiru Li,

Zicong Liao

et al.

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 855, P. 158807 - 158807

Published: Sept. 14, 2022

Language: Английский

Citations

31
Thyroid Hormone Disruption by Organophosphate Esters Is Mediated by Nuclear/Membrane Thyroid Hormone Receptors: In Vitro, In Vivo, and In Silico Studies DOI
Jian Li, Ying Xu, Na Li

et al.

Environmental Science & Technology, Journal Year: 2022, Volume and Issue: 56(7), P. 4241 - 4250

Published: March 9, 2022

Earlier mechanistic studies of many prohibited flame retardants (FRs) highlighted their thyroid hormone-disrupting activity through nuclear hormone receptors (nTRs), whereas some alternative FRs such as organophosphate esters (OPEs) exerted weak nTR-disrupting effects. However, an increasing number have revealed that OPEs also exert effects, and the underlying mechanism is unclear. Herein, effects mechanisms 8 typical were investigated using integrated in vitro, vivo, silico assays. All tested chemicals competitively bound to membrane receptor (mTR) [the 20% relative inhibitory concentration (RIC20): (3.5 ± 0.2) × 101 (4.9 1.0) 107 nM], Cl-OPEs alkyl-OPEs had lower RIC20 values. In contrast, only 4 showed nTR antagonistic activities at higher concentrations [≥ (4.8 0.8) 103 nM]. preferentially interacted with mTR. Molecular docking illustrated docked into mTRs, consistent competitive binding assay. vivo analyses zebrafish embryonic development confirmed tris(1,3-dichloro-2-propyl) phosphate induced inappropriate expression proteins, these protein interactions might be associated mTR according quantitative proteomic analysis. Based on results, play a critical role mediating OPEs.

Language: Английский

Citations

30
Uptake, accumulation, and translocation of organophosphate esters and brominated flame retardants in water hyacinth (Eichhornia crassipes): A field study DOI
Huiru Li, Zhilang Lao, Yishan Liu

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 874, P. 162435 - 162435

Published: Feb. 24, 2023

Language: Английский

Citations

19
Investigation on the interaction of aromatic organophosphate flame retardants with human serum albumin via computer simulations, multispectroscopic techniques and cytotoxicity assay DOI

Xiulan Ma,

Lin Kuang,

Xiaowei Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 247, P. 125741 - 125741

Published: July 7, 2023

Language: Английский

Citations

19
Organophosphate esters in soils of Beijing urban parks: Occurrence, potential sources, and probabilistic health risks DOI
Y.X. Tian,

Y. Wang,

H.Y. Chen

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 879, P. 162855 - 162855

Published: March 15, 2023

Language: Английский

Citations

17