Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2021, Volume and Issue: 251, P. 109199 - 109199
Published: Oct. 2, 2021
Language: Английский
Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(25), P. 9287 - 9297
Published: June 12, 2023
Broad screening approaches for monitoring wastewater are normally based on reversed-phase liquid chromatography (LC) coupled to high-resolution mass spectrometry (HRMS). This method is not sufficient the very polar micropollutants, neglected in past due a lack of suitable analytical methods. In this study, we used supercritical fluid (SFC) detect and yet-undetected micropollutants effluents. We tentatively identified 85 compounds, whereas 18 have only rarely been detected 11 previously effluents such as 17α-hydroxypregnenolone, likely transformation product (TP) steroids, 1H-indole-3-carboxamide, TP from new synthetic cannabinoids. Suspect 25 effluent samples 8 treatment plants revealed several distinct potential pollution sources pharmaceutical company golf court. The analysis same with LC–HRMS showed clearly how SFC increases ionization efficiency low-molecular-weight (m/z < 300 Da) by factor 2 87 times, which significantly improved spectra identifying compounds. order assess might be environmental concern, literature toxicological databases were screened. There was available hazard bio-activity data regulatory-relevant vitro vivo assays >50% micropollutants. Especially, 70% lacking whole organism (in vivo) tests.
Language: Английский
Citations
10
Brain Research Bulletin, Journal Year: 2025, Volume and Issue: 221, P. 111214 - 111214
Published: Jan. 16, 2025
Language: Английский
Citations
0
The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 852, P. 158503 - 158503
Published: Sept. 2, 2022
Language: Английский
Citations
15
Environmental Toxicology and Chemistry, Journal Year: 2023, Volume and Issue: 42(8), P. 1709 - 1720
Published: June 7, 2023
Metformin, used to treat Type 2 diabetes, is the active ingredient of one most prescribed drugs in world, with over 120 million yearly prescriptions globally. In wastewater-treatment plants (WWTPs), metformin can undergo microbial transformation form product guanylurea, which could have toxicological relevance environment. Surface water samples from 2018 2020 and sediment were collected six mixed-use watersheds Quebec Ontario, Canada, analyzed determine guanylurea concentrations at each site. Metformin present above their limits quantification 51.0% 50.7% all 64% 21% samples, respectively. surface water, was often higher than metformin, while inverse true sediment, frequently detected guanylurea. addition, sites influenced solely by agriculture, <1 µg/L suggesting that agriculture not a significant source these compounds investigated watersheds. These data suggest WWTPs potentially septic system leaks are likely sources Guanylurea many environmental concern, where critical processes fish may be affected. Due scarcity available ecotoxicological prominence across sample sites, there need perform more investigations this revisit regulations. The study will help provide toxicologists environmentally relevant concentration ranges Canada. Environ Toxicol Chem 2023;42:1709-1720. © 2023 His Majesty King Right Canada Authors. Environmental Toxicology Chemistry published Wiley Periodicals LLC on behalf SETAC. Reproduced permission Minister Agriculture Agri-Food
Language: Английский
Citations
8
Environmental Research, Journal Year: 2024, Volume and Issue: 247, P. 118173 - 118173
Published: Jan. 14, 2024
Language: Английский
Citations
3
Catalysts, Journal Year: 2024, Volume and Issue: 14(9), P. 620 - 620
Published: Sept. 14, 2024
Water from Madín Dam in Mexico has been shown to contain a wide variety of pollutants such as drugs, pesticides, personal care products and compounds that are released into the environment waste production processes. In this work, effect main process variables on percentage total organic carbon (TOC) removal water samples reservoir was studied by applying photo-Fenton treatment catalyzed with iron-pillared clays. The catalyst characterized XRD, N2 physisorption, DRS XPS. sampling characterization carried out according Mexican standards. system for tests 0.1 L reaction volume controlled temperature 23–25 °C, kept under constant stirring. After 4 h time UV light, TOC 90%, it 60% Vis light. ROS involved driven UVC light were hydroxyl radicals, while hydroperoxyl radicals predominate Vis-light-driven process. Evidence superoxide anion participation not found. toxicity untreated treated assessed Danio rerio specimens, observed be reduced after treatment.
Language: Английский
Citations
3
The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 829, P. 154689 - 154689
Published: March 18, 2022
Language: Английский
Citations
14
Environmental Science & Technology, Journal Year: 2022, Volume and Issue: 56(14), P. 10193 - 10203
Published: June 24, 2022
Metformin is routinely detected in aquatic ecosystems because of its widespread use as a treatment for Type 2 diabetes. Laboratory studies have shown that exposure to environmentally relevant concentrations metformin can alter metabolic pathways and impact the growth early life stage (ELS) fish; however, it unknown whether these effects occur wild populations. Herein, we evaluate findings from laboratory are representative describe relative sensitivities both Duplicate exposures (0, 5, or 50 μg/L metformin) were conducted using wild- lab-spawned fathead minnow (Pimephales promelas) embryos. Apart water source, conditions remained constant. Wild embryos exposed previously dosed lake account changes bioavailability, while reconstituted freshwater was used study. Developmental differentially impacted morphology cohorts, with energy dyshomeostasis visual indicated. The fitness wild-spawned larvae greater extent fish. Moreover, baseline data reveal important morphological differences between ELS fatheads may diminish representativeness lab studies. Findings also confirm bioavailability naturally occurring systems suggest current scenarios be sufficient negatively developing
Language: Английский
Citations
14
Aquaculture, Journal Year: 2024, Volume and Issue: 588, P. 740957 - 740957
Published: April 15, 2024
Language: Английский
Citations
2
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 929, P. 172457 - 172457
Published: April 21, 2024
Due to its widespread use for the treatment of Type-2 diabetes, metformin is routinely detected in surface waters globally. Laboratory studies have shown that environmentally relevant concentrations can adversely affect health adult fish, with effects observed more frequently males. However, potential risk wild fish populations has yet be fully elucidated and remains a topic debate. To explore whether exposure poses populations, present study exposed fathead minnows (Pimephales promelas) 5 or 50 μg/L via 2 m diameter in-lake mesocosms deployed natural boreal lake Northern Ontario at International Institute Sustainable Development - Experimental Lakes Area (IISD-ELA). Environmental monitoring was performed regular intervals 8-weeks, length, weight (body, liver gonad), condition factor, gonadosomatic index, liver-somatic body composition (water biomolecules) hematocrit levels evaluated test termination. Metabolic endpoints were also using liver, brain muscle tissue, gonads histologically. Results indicate current environmental scenarios may sufficient impact populations. Adult male had significantly reduced whole factor several from high-dose oocytes their testes. Metformin-exposed altered moisture lipid (decrease) content tissues. Further, (increase) glycogen metformin. our knowledge, this constitutes first effort understand metformin's on small-bodied population under field conditions.
Language: Английский
Citations
2